Can we reduce the number of fish in the OECD acute toxicity test?

Environmental Toxicology and Chemistry

Volumn 30, Issue 4, 2011, Pages 1006-1011

  Rufli, Hans ^a   Springer, Timothy A ^b  

^a Ecotoxsolutions   (Switzerland)

^b Wildlife International Ltd   (United States)

Author keywords

Concentration response slope; Concentration separation factor; Fish acute test; Fish embryo test; Fish rangefinder

Indexed keywords

ACUTE TOXICITY TEST; CONCENTRATION RESPONSE SLOPE; CONCENTRATION SEPARATION FACTOR; DAPHNIA; EFFECTIVE CONCENTRATION; EFFICIENT DESIGNS; FISH EMBRYO TEST; FISH EMBRYOS; JUVENILE FISH; LETHAL CONCENTRATION; MONTE CARLO; ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; PARTIAL MORTALITY; POINT ESTIMATE; SEPARATION FACTORS; THRESHOLD CONCENTRATIONS;

COMPUTER SIMULATION; CONCENTRATION (PROCESS); INTERNATIONAL COOPERATION; RANGE FINDERS; TESTING; TOXICITY;

FISH;

DOSE-RESPONSE RELATIONSHIP; EMBRYO; FISH; MONTE CARLO ANALYSIS; MORTALITY; NUMERICAL MODEL; PARADIGM SHIFT; SUBLETHAL EFFECT; TOXICITY TEST;

ARTICLE; CONCENTRATION (PARAMETERS); DATA BASE; EMBRYO; LABORATORY TEST; MONTE CARLO METHOD; MORTALITY; NONHUMAN; ORGANIZATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; TOXICITY TESTING;

ACUTE TOXICITY TESTS; ANIMALS; FISHES; GUIDELINES AS TOPIC; LETHAL DOSE 50; MONTE CARLO METHOD; ORGANIZATIONS;

ALGAE; DAPHNIA;

EID: 79952297320     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.465     Document Type: Article

References (10)

1. Organisation for Economic Co-operation and Development. 1992. Fish, Acute Toxicity Test. OECD Guideline 203. Paris, France.
2. Finney DJ. 1964. Statistical Method in Biological Assay. Charles Griffin, London, United Kingdom, pp 1-668.
3. Litchfield JT, Wilcoxon F. 1949. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96: 99-113.
4. Organisation for Economic Co-operation and Development. 2007. Avian Acute Oral Toxicity Test. Proposal for a new OECD Guideline 223. Paris, France.
5. Organisation for Economic Co-operation and Development. 2006. 48h-Fish Embryo Toxicity Test (FET). Draft Proposal for a New OECD Test Guideline. Paris, France.
6. Jeram S, Riego Sintes JM, Halder M, Baraibar Fentanes J, Sokull-Klüttgen B, Hutchinson TH. 2005. A strategy to reduce the use of fish in acute ecotoxicity testing of new chemical substances notified in the European Union. Regul Toxicol Pharmacol 42: 218-224.
7. Organisation for Economic Co-operation and Development. 2009. The Threshold Approach for Acute Fish Toxicity Testing. Draft OECD Guidance Document. Paris, France.
8. European Commission. 2010. Directive 2010/63/EU of the European Parliament and the Council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union L 276, 20.10. pp 33-79.
9. Belanger SE, Balon EK, Rawlings JM. 2010. Saltatory ontogeny of fishes and sensitive early life stages for ecotoxicology tests. Aquat Toxicol 97: 88-95.
10. Weyers A, Sokull-Klüttgen B, Baraibar-Fentanes J, Vollmer G. 2000. Acute toxicity data: a comprehensive comparison of results of fish, Daphnia and algae tests with new substances notified in the EU. Environ Toxicol Chem 19: 1931-1933.