Synthesis and antidiabetic activity of N'-[3-(alkyl/aryl substituted)-4-oxo-1,3 thiazolidin-2-yeidene]-2-(pyrazin-2-yloxy)acetohydrazide

Acta Pharmaceutica Sciencia

Volumn 52, Issue 4, 2010, Pages 410-414

  Verma, Prabhakar ^a   Kamboj, Vipan ^a  

^a MAHARSHI DAYANAND UNIVERSITY   (India)

Author keywords

Antihyperglycemic; Glycaemic; Hypoglycaemic; Thiazolidinone; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; INSULIN; N' [3 (2 NITRO 4 CHLORO) 4 OXO 1,3 THIAZOLINDIN 2 YLIDENE] 2 (PYRAZIN 2 YLOXY)ACETOHYDRAZIDE; N' [3 (2,4 DICHLOROPHENYL) 4 OXO 1,3 THIAZOLINDIN 2 YLIDENE] 2 (PYRAZIN 2 YLOXY)ACETOHYDRAZIDE; N' [3 (4 CHLOROPHENYL) 4 OXO 1,3 THIAZOLINDIN 2 YLIDENE] 2 (PYRAZIN 2 YLOXY)ACETOHYDRAZIDE; N' [3 (4 ETHOXYPHENYL) 4 OXO 1,3 THIAZOLINDIN 2 YLIDENE] 2 (PYRAZIN 2 YLOXY)ACETOHYDRAZIDE; N' [3 (ISOPROPYL) 4 OXO 1,3 THIAZOLINDIN 2 YLIDENE] 2 (PYRAZIN 2 YLOXY)ACETOHYDRAZIDE; N' [3 (N BUTYL) 4 OXO 1,3 THIAZOLINDIN 2 YLIDENE] 2 (PYRAZIN 2 YLOXY)ACETOHYDRAZIDE; N' [3 (PHENYL) 4 OXO 1,3 THIAZOLINDIN 2 YLIDENE] 2 (PYRAZIN 2 YLOXY)ACETOHYDRAZIDE; N' [3 (TERT BUTYL) 4 OXO 1,3 THIAZOLINDIN 2 YLIDENE] 2 (PYRAZIN 2 YLOXY)ACETOHYDRAZIDE; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; INFRARED SPECTROSCOPY; INSULIN BLOOD LEVEL; LD 50; MELTING POINT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET RADIATION;

EID: 79952289792     PISSN: 13072080     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Alshamaony, L., Al Khazaraji, S.M. and Twalj, H.A. (1994). Hypoglycemic effect of Artemisia herba alba. J. Ethanopharmacol. 43: 167-171.
2. Bue-Valleskey, J.M., Hunden, D.C., Jones, C.D., Panetta, J.A. and Shaw, W.N. (1996). Compounds useful as hypoglycemic agents and for treating Alzheimer's disease. United States Patent, US 5523314; Chem. Abst. 123: 13816.
3. Okuyama, S., Hiroyuki, O. and Kawamura, M. (1995). Rhodadine derivative. Japanese Patent, JP 7070095; Chem. Abst, 123: 55868.
4. Panetta, J.A., Bue-Valleskey, J.M., Munden, D.C., Jones, C.D. and Shaw, W.N. (1997). Hypoglycemic Agents. United States Patent, US 5661168; Chem. Abst, 125: 117581.
5. Porte, D. Jr and Schwartz, M.W. (1996). Diabetes complications: Why is glucose potentially toxic? Science 272: 699-670.
6. The Diabetes control and complications trial research group. (1993). The Effect of intensive treatment on the development and progression of long term complication in insulin-dependant diabetes mellitus. N. Engl. J. Med. 329: 977-986.