Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1103-1116

  Chorell, Erik ^a   Bengtsson, Christoffer ^a   Sainte Luce Banchelin, Thomas ^a   Das, Pralay ^a,b   Uvell, Hanna ^a   Sinha, Arun K ^a,b   Pinkner, Jerome S ^c   Hultgren, Scott J ^c   Almqvist, Fredrik ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b NATIONAL CHEMICAL LABORATORY   (India)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 Pyridone; Anti virulence; peptidomimetic; Pilicide

Indexed keywords

6 BROMOMETHYL 2,2 DIMETHYL[1,3]DIOXIN 4 ONE; 7 BROMOMETHYL 5 OXO 8 (3 TRIFLUOROMETHYLPHENYL) 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDINE 3 CARBOXYLIC ACID METHYL ESTER; 7 BROMOMETHYL 8 CYCLOPROPYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDINE 3 CARBOXYLIC ACID METHYL ESTER; 8 (3 TRIFLUOROMETHYL)PHENYL 7 AMINO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 (3 TRIFLUOROMETHYL)PHENYL 7 AZIDO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 (3 TRIFLUOROMETHYL)PHENYL 7 BENZENESULFONAMIDO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 (3 TRIFLUOROMETHYL)PHENYL 7 MORPHOLINO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 (3 TRIFLUOROMETHYL)PHENYL 7 PIPERIDINO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 (3 TRIFLUOROMETHYL)PHENYL 7 TETRAHYDROISOQUINOLINO1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 AMINO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 AZIDO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 BENZAMIDO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 BENZENESULFONAMIDO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 MORPHOLINO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 NAPHTHALAMIDO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 NAPHTHALENESULFONAMIDO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 PIPERIDINO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; 8 CYCLOPROPYL 7 TETRAHYDROISOQUINOLINO 1 YLMETHYL 5 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2A]PYRIDIN 3 CARBOXYLIC ACID METHYL ESTER; AMIDE; AMINE; ANTIINFECTIVE AGENT; BROMINE DERIVATIVE; CARBON; DIHYDROTHIAZOLO 2 PYRIDONE PILICIDE; ETHER DERIVATIVE; METHYL GROUP; PEPTIDOMIMETIC AGENT; PILICIDE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; CHEMICAL BOND; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; STRUCTURE ACTIVITY RELATION;

ALCOHOLS; AMINES; ANTI-BACTERIAL AGENTS; AZIDES; CARBON; ESCHERICHIA COLI; OXIDATION-REDUCTION; VIRULENCE;

EID: 79952283041     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.025     Document Type: Article

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