Design of semisynthetic analogues and 3D-QSAR study of eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1122-1130

  Hassan, Hossam M ^a,b   Elnagar, Ahmed Y ^a   Khanfar, Mohammad A ^a   Sallam, Asmaa A ^a   Mohammed, Rabab ^b   Shaala, Lamiaa A ^c   Youssef, Diaa T A ^d   Hifnawy, Mohamed S ^e   El Sayed, Khalid A ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b Beni Suef University   (Egypt)

^c Suez Canal University   (Egypt)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^e CAIRO UNIVERSITY   (Egypt)

Author keywords

3D QSAR; Anti invasive; Anti migratory; Cladiellisin; CoMFA; CoMSIA; Eunicellin diterpenoids; Marine natural products; Prostate cancer

Indexed keywords

17 EPOXYCLADIELLISIN; 17 EPOXYCLADIELLISIN 6 YL BENZYL(BENZYLCARBAMOYL)CARBAMATE; 17 EPOXYCLADIELLISIN 6 YL BUTYLCARBAMATE; 3 ACETYLCLADIELLISIN; 3,6 DIACETYLCLADIELLISIN; ANTINEOPLASTIC AGENT; CARBAMIC ACID DERIVATIVE; CLADIELLIN; CLADIELLISIN 6 YL 3 CHLOROPROPYLCARBAMATE; CLADIELLISIN 6 YL ALLYL[ALLYL(ALLYLCARBAMOYL)CARBAMOYL]CARBAMATE; CLADIELLISIN 6 YL BENZYL(BENZYLCARBAMOYL)CARBAMATE; CLADIELLISIN 6 YL BUTYLCARBAMATE; CLADIELLISIN 6 YL OCTYLCARBAMATE; CLADIELLISIN 6 YL PENTYLCARBAMATE; CLADIELLISIN 6 YL PHENYLCARBAMATE; CLADIELLISIN DERIVATIVE; DITERPENOID; EUNICELLIN DERIVATIVE; KLYSIMPLEXIN E DERIVATIVE; PACHYCLADIN A; PACHYCLADIN C; PACHYCLADIN D; PACHYCLADIN DERIVATIVE; PACHYCLADIN E; PATAGONICOL; POLYANTHELIN A; SCLEROPHYTIN A; SCLEROPHYTIN B; SCLEROPHYTIN F METHYL ESTER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CONTROL; CANCER INHIBITION; CANCER INVASION; CARBAMOYLATION; CELL STRAIN; CELL STRAIN PC 3; CLADIELLA PACHYCLADOS; CONTROLLED STUDY; CORAL; DRUG DESIGN; DRUG DETERMINATION; EPOXIDATION; HUMAN; HUMAN CELL; IC 50; METASTASIS POTENTIAL; PROSTATE CANCER; QUANTITATIVE STRUCTURE ACTIVITY RELATION; WOUND HEALING;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; DITERPENES; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEOPLASM INVASIVENESS; PROSTATIC NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952282256     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.028     Document Type: Article

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