Regulation of sodium transporters in the kidney during cyclosporine treatment

Journal of Nephrology

Volumn 23, Issue SUPPL.16, 2010, Pages

  Damiano, Sara ^a   Scanni, Roberto ^a   Ciarcia, Roberto ^b   Florio, Salvatore ^b   Capasso, Giovambattista ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cyclosporine; Hypertension; Nephrotoxicity; Sodium transport

Indexed keywords

CYCLOSPORIN; EPITHELIAL SODIUM CHANNEL; IMMUNOSUPPRESSIVE AGENT; REACTIVE OXYGEN METABOLITE; SODIUM; SODIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2 PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM-HYDROGEN EXCHANGER 3; SODIUM-POTASSIUM CHLORIDE COTRANSPORTER 2 PROTEIN;

ABSORPTION; ANIMAL; DRUG EFFECT; HUMAN; KIDNEY; METABOLISM; PHYSIOLOGY; REVIEW;

ABSORPTION; ANIMALS; CYCLOSPORINE; EPITHELIAL SODIUM CHANNEL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; REACTIVE OXYGEN SPECIES; SODIUM; SODIUM CHLORIDE SYMPORTERS; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 79952279193     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Kahan B. Cyclosporine. N Engl J Med. 1989;321:1725-1738.
2. Tocci M, Matkovich D, Collier K, et al. The immunosuppressant FK 506 selectively inhibits expression of early T cell activation genes. J Immunol. 1989;143:718-726.
3. Sigal N, Dumont F. Cyclosporine A, FK-506, and rapamycin: pharmacological probes of lymphocyte signal transduction. Annu Rev Immunol. 1992;10:519-560.
4. Handschumacher R, Harding M, Rice J, Druggs R, Speicher D. Cyclophilin: a specific cytosolic binding protein for cyclosporine A. Science. 1984;226:544-547.
5. Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991;66:807-815.
6. Galletti P, Di Gennaro CI, Migliardi V, et al. Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cells. Nephrol Dial Transplant. 2005;20:1551-1558.
7. Ciresi DL, Lloyd MA, Sandberg SM, Henblein DM, Edward BS. The sodium retaining effects of cyclosporine. Kidney Int. 1992;41:1599-1605.
8. Guyton AC. Dominant role of the kidneys and accessory role of whole-body autoregulation in the pathogenesis of hypertension. Am J Hypertens. 1989;2:575-585.
9. Ryffel B, Hiestand P, Foxwell B, et al. Nephrotoxic and immunosuppressive potentials of cyclosporine metabolites in rats. Transplant Proc. 1986;18(6 Suppl 5):41-45.
10. Kaskel FJ, Devarajan P, Arbeit LA, Partin JS, Moore LC. Cyclosporine nephrotoxicity: sodium excretion, autoregulation, and angiotensin II. Am J Physiol. 1987;252(4 Pt 2):F733-F742.
11. Mervaala EM, Pere AK, Lindgren L, et al. Effects of dietary sodium and magnesium on cyclosporin A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats. Hypertension. 1997;29:822-827.
12. Curtis JJ. Hypertension following kidney transplantation. Am J Kidney Dis. 1994;23:471-475.
13. Grabtree G. Contingent genetic regulatory events in T lymphocyte activation. Science. 1989;243:355-361.
14. Koeppen M, Stanton BA. Renal physiology. St. Louis, MO: Mosby Year Book. 4th ediction. 2007
15. Epting T, Hartmann K, Sandqvist A, Nitschke R, Gordjani N. Cyclosporin A stimulates apical Na+/H+ exchange in LLC-PK1/PKE20 proximal tubular cells. Pediatr Nephrol. 2006;21:939-946.
16. Thomson SC, Tucker BJ, Gabbai F, Blantz RC. Functional effects on glomerular hemodynamics of short-term chronic cyclosporine in male rats. J Clin Invest. 1989;83:960-969.
17. Mihatsch MJ, Ryffel B, Hermle M, Brunner FP, Thiel G. Morphology of cyclosporine nephrotoxicity in the rat. Clin Nephrol. 1986;25 Suppl 1:S2-8
18. Esteva-Font C, Ars E, Guillen-Gomez E, et al. Cyclosporininduced hypertension is associated with increased sodium transporter of the loop of Henle (NKCC2). Nephrol Dial Transplant. 2007;22:2810-2816.
19. Capasso G, Di Gennaro CI, Della Ragione F, et al. In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats. Nephrol Dial Transplant. 2008;23:1186-1195.
20. Kiil F, Ostensen J. Essential of glomerulotubular balance. Acta Physiol Pharmacol Bulg. 1989;15:3-12.
21. Masilamani S, Knepper MA, Burg MB. Urine concentration and dilution. In: Brenner BM, ed. The kidney. 6th ed. Philadelphia, PA: Saunders; 2000:595-636.
22. Lorenz JN, Schultheis PJ, Traynor T, et al. Micropuncture analysis of single nephron function in NHE3-deficient mice. Am J Physiol. 1999;277:F447-F453.
23. Takahashi N, Chernavvsky DR, Gomez RA, et al. Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci U S A. 2000;97:5434-5439.
24. Wheatley HC, Datzman M, Williams JW, Miles DE, Hatch FE. Long-term effects of cyclosporine on renal function in liver transplant recipients. Transplantation. 1987;43:641-647.
25. Ferrer-Martinez A, Felipe A, Barcelo P, Casado FJ, Ballarin J, Pastor-Anglada M. Effects of cyclosporine A on Na,K-ATPase Phys expression in the renal epithelial cell line NBL-1. Kidney Int. 1996;50:1483-1489.
26. Greger R, Schlatter E, Lang F. Evidence for electroneutral sodium chloride cotransport in the cortical thick ascending limb of Henle's loop of rabbit kidney. Am J Physiol. 1996;271:F588-F594.
27. Reeves WB, Winters CJ, Zimniak L, Andreoli TE. Properties and regulation of medullary thick limb basolateral Cl2 channels. Kidney Int. 1998;53(Suppl 65):S24-S28.
28. Tumlin JA, Sands JM. Nephron segment-specific inhibition of Na1/K1-ATPase activity by cyclosporin A. Kidney Int. 1993;43:246-251.
29. Vandewalle A, Vuillemin T, Teulon J, et al. K1 fluxes mediated by Na1-K1-Cl2 cotransport and Na1-K1-ATPase pumps in renal tubule cell lines transformed by wild-type and temperature-sensitive strains of Simian virus 40. J Cell Physiol. 1993;154:466-477.
30. Wu MS, Yu HM, Hong JJ, Lai BC, Huang CC, Vandewalle A. Cyclosporine, but not FK 506 and rapamycin, enhances cell proliferation in mouse medullary thick ascending cultured cells. Transplant Proc. 1998;30:3565-3566.
31. Dong J, Delamere NA, Coca-Prados M. Inhibition of Na1-K1-ATPase activates Na1 K1-2Cl2 cotransporter activity in cultured ciliary epithelium. Am J Physiol. 1994;266:C198-C205.
32. Hoagland KM, Flasch AK, Dahly-Vernon AJ, dos Santos EA, Knepper MA, Roman RJ. Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys. Hypertension. 2004;43:860-865.
33. Snyder PM. The epithelial Na+ channel: cell surface insertion and retrieval in Na+ homeostasis and hypertension. Endocr Rev. 2002;23:258-275.
34. Pratt JH. Central role for ENaC in development of hypertension. J Am Soc Nephrol. 2005;16:3554-3159.
35. Saha C, Eckert GJ, Ambrosius WT, et al. Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension. Hypertension. 2005;46:481-487.
36. Swift PA, MacGregor GA. The epithelial sodium channel in hypertension: genetic heterogeneity and implications for treatment with amiloride. Am J Pharmacogenomic. 2004;4:161-168.
37. Lippe C, Bellantuono V, Quaranta A, Castronuovo G, Cassano G, Ardizzone C. Cyclosporin A stimulates Na+ transport across the isolated skin of Rana esculenta. Arch Physiol Biochem. 1997;105:596-602.
38. Wang J, Zhang ZR, Chou CF, Liang YY, Gu Y, Ma HP. Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol. Am J Physiol Renal Physiol. 2009;296:F284-F290.
39. Parra Cid T, Conejo Gracia JR, Carballo AF, De Arriba G. Antioxidant nutrients protect against cyclosporine A nephrotoxicity. Toxicology. 2003;189:99-111.
40. Calo LA, Davis PA, Giacon B, et al. Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002;40:625-631.
41. Nishiyama A, Kobori H, Fukui T, et al. Role of angiotensin II and reactive oxygen species in cyclosporine A-dependent hypertension. Hypertension. 2003;42;754-760.
42. Navar LG, Harrison-Bernard LM, Nishiyama A, Kobori H. Regulation of intrarenal angiotensin II in hypertension. Hypertension. 2002;39:316-322.
43. Diederich D, Skopec J, Diederich A, Dai FX. Cyclosporine produces endothelial dysfunction by increased production of superoxide. Hypertension. 1994;23:957-961.
44. Jeon SH, Piao YJ, Choi KJ, et al. Prednisolone suppresses cyclosporin A-induced apoptosis but not cell cycle arrest in MDCK cells. Arch Biochem Biophys. 2005; 435:382-392.
45. Perez de Hornedo J, De Arriba G, Fernandez C, Benito S, Parra Cid T. Cyclosporin A causes oxidative stress and mitochondrial dysfunction in tubular renal cells. Nefrologia. 2007;27:565-573.
46. Nieminen AL, Byrne AM, Herman B, Lemasters JJ. Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species. Am J Physiol. 1997;272(4 Pt 1):C1286-C1294.
47. Shiino A, Matsuda M, Handa J, Chance B. Poor recovery of mitochondrial redox state in CA1 after transient forebrain ischemia in gerbils. Stroke. 1998;29:2421-2424.
48. Galindo MF, Jordán J, González-García C, Ceña V. Reactive oxygen species induce swelling and cytochrome C release but not transmembrane depolarization in isolated rat brain mitochondria. Br J Pharmacol. 2003;139:797-804.
49. Vetter M, Chen ZJ, Chang GD, Che D, Liu S, Chang CH. Cyclosporin A disrupts bradykinin signaling through superoxide. Hypertension. 2003;41:1136-1142.