Retroperitoneal dedifferentiated liposarcomas with production of β-human chorionic gonadotropin - A distinct sarcoma entity?

Onkologie

Volumn 34, Issue 3, 2011, Pages 122-125

  Schöffski, Patrick ^a   Sweldens, Caroline ^a   Vanderbeeken, Marie Catherine ^a   Forceville, Kathleen ^a   Vandenbroucke, Johan ^b   Dubin, Marleen ^b   Debiec Rychter, Maria ^b   Wozniak, Agnieszka ^a   Sciot, Raf ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b Department of Internal Medicine ^*  (Belgium)

Author keywords

human chorionic gonadotropin; Dedifferentiated liposarcoma; Differentiation; Liposarcoma

Indexed keywords

ANALGESIC AGENT; CHORIONIC GONADOTROPIN BETA SUBUNIT; KERATIN; PROTEIN MDM2; STEROID;

ADRENAL METASTASIS; ADULT; ANALGESIA; ARTICLE; ASCITES; ASTHENIA; BONE METASTASIS; BRAIN DAMAGE; CANCER GROWTH; CANCER PAIN; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CASE REPORT; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; DYSPNEA; EPITHELIUM TUMOR; FATIGUE; FLUORESCENCE IN SITU HYBRIDIZATION; GENERAL CONDITION DETERIORATION; HISTOPATHOLOGY; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; HYDROURETER; IMMUNOHISTOCHEMISTRY; LEG PAIN; LIPOSARCOMA; LUNG METASTASIS; LYMPHADENOPATHY; MALE; MUSCLE BIOPSY; POOR GENERAL CONDITION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PSEUDOSARCOMATOUS EPITHELIAL TUMOR; PSOAS MUSCLE; RETROPERITONEAL DEDIFFERENTIATED LIPOSARCOMA; STEROID THERAPY; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TUMOR DIFFERENTIATION;

CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; HUMANS; LIPOSARCOMA; MALE; MIDDLE AGED; RETROPERITONEAL NEOPLASMS;

EID: 79952266906     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000324786     Document Type: Article

References (22)

1. Russell M.J.Flynt F.L.Harroff A.L.Fadare O. Dedifferentiated liposarcoma of the retroperitoneum with extensive leiomysarcomatous differentiation and b-human chorionic gonadetropin production. Sarcoma 2008;2008:658090.
2. Evans H.L. Liposarcoma: A study of 55 cases with a reassessment of its classification Am. J. Surg. Pathol. 1979 3 507-523 (Pubitemid 10203768)
3. Henricks WH, Chu YC, Goldblum JR, Weiss SW: Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Patho 1997;21:271-281. (Pubitemid 27120195)
4. Coindre JM, Mariani O, Chibon F, Mairal A, De Saint Aubain Somerhausen N, Favre-Guillevin E, Bui NB, Stoeckle E, Hostein I, Aurias A: Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. Mod Pathol 2003; 16:256-262. (Pubitemid 36337432)
5. Coindre JM, Mariani O, Chibon F, Mairal A, De Saint Aubain Somerhausen N, Favre-Guillevin E, Bui NB, Stoeckle E, Hostein I, Aurias A: Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. Mod Pathol 2003; 16:256-262.
6. Evans H.L.Khurana K.K.Kemp B.L.Ayala A.G. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma Am. J. Surg. Pathol. 1994 18 1150-1157 (Pubitemid 24337622)
7. Stevens VC: Human chorionic gonadotrophin: properties and potential immunological manipulation for clinical application. Clin Obstet Gynaecol 1979;6:549-566. (Pubitemid 10196830)
8. Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW: Crystal structure of human chorionic gonadotropin, Nature 1994;369:455-461. (Pubitemid 24210564)
9. Iles R.K. Ectopic hCGb expression by epithelial cancer: Malignant behaviour metastasis and inhibition of tumor cell apoptosis Mol. Cell Endocrinol. 2007 260 262 264-270 (Pubitemid 44792339)
10. Gailani S, Chu TM, Nussbaum A, Ostrander M, Christoff N: Human chorionic gonadotrophins (hCG) in nontrophoblastic neoplasms. Assessment of abnormalities of hCG and CEA in bronchogenic and digestive neoplasms. Cancer 1976;38:1684- 1686.
11. Ordonez NG, Ayala AG, Raymond AK, Plager C, Benjamin RS, Samaan NA: Ectopic production of the b-subunit of human chorionic gonadotropin in osteosarcoma. Arch Pathol Lab Med 1989;113:416- 419. (Pubitemid 19110439)
12. Ordonez NG, Ayala AG, Raymond AK, Plager C, Benjamin RS, Samaan NA: Ectopic production of the b-subunit of human chorionic gonadotropin in osteosarcoma. Arch Pathol Lab Med 1989;113:416- 419. (Pubitemid 14101786)
13. Leidinger B, Bielack S, Koehler G, Vieth V, Winkelmann W, Gosheger G: High level of b-hCG simulating pregnancy in recurrent osteosarcoma: case report and review of literature. J Cancer Res Clin Oncol 2004;130:357-361. (Pubitemid 38858347)
14. Mack GR, Robey DB, Kurman RJ: Chondrosarcoma secreting chorionic gonadotropin: report of a case. J Bone Joint Surg 1977;59:1107-1111. (Pubitemid 8248164)
15. Meredith RF, Wagman LD, Piper JA, Mills AS, Neifeld JP: b-chain human chorionic gonadotropinproducing leiomyosarcoma of the small intestine. Cancer 1986;58:131-135. (Pubitemid 16093115)
16. Seidl C, Lippert C, Grouls V, Jellinghaus W: Leiomyosarcoma of the spermatic cord with paraneoplastic b-hCG production. Pathologe 1998;19:146-150. (Pubitemid 28125884)
17. Liang S, Stone G, Chalas E, Pearl M, Callan F, Zheng W: A high-grade uterine leiomyosarcoma with human chorionic gonadotropin production. Int J Gynecol Pathol 2006;25:257-261.
18. Ou SM, Lee SS, Peng YJ, Sheu LF, Yao NS, Chang SY: Production of b-hCG by spermatic cord leiomyosarcoma: a paraneoplastic syndrome? J Androl 2006;27:643-644.
19. Mansi I.A.Ashley I.Glezerov V. Retroperitoneal leiomyosarcoma and enlarged epididymis associated with a positive pregnancy test Am. J. Med. Sci. 2002 324 104-105 (Pubitemid 34851734)
20. Froehner MP, Gaertner HJ, Manseck A, Oehlschlaeger S, Wirth MP: Retroperitoneal leiomyosarcoma associated with an elevated b-hCG serum level mimicking extragonadal germ cell tumor. Sarcoma 2000;4:179-181. (Pubitemid 32055725)
21. Binh MBN, Sastre-Garau X, Guillou L, de Pinieux G, Terrier P, Lagacé R, Aurias A, Hostein I, Coindre JM: MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 2005;29:1340-1347. (Pubitemid 41368770)
22. Dahlin DC and Beabout JW: Dedifferentiation of low-grade chondrosarcomas. Cancer 1971;28:461- 466.