Potential applications of gene therapy/transfer to the treatment of lower urinary tract diseases/disorders

Handbook of Experimental Pharmacology

Volumn 202, Issue , 2011, Pages 255-265

  Christ, George J ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Benign disease; Bladder; Gap junctions; Gene therapy; Gene transfer; Localized delivery; Quality of life; Smooth muscle; Ureter; Urethra; Urothelium

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; GLUTAMATE DECARBOXYLASE; LIPOSOME; MANGANESE SUPEROXIDE DISMUTASE; MUSCARINIC M3 RECEPTOR; NAKED DNA; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR BETA SUBUNIT; POTASSIUM CHANNEL; PROENKEPHALIN; PROOPIOMELANOCORTIN; SCATTER FACTOR; VIRUS VECTOR;

ARTICLE; BIOTECHNOLOGY; BLADDER DISEASE; BLADDER FUNCTION; BLADDER WALL FIBROSIS; CYSTALGIA; CYSTITIS; DETRUSOR DYSSYNERGIA; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; ELECTROPORATION; EX VIVO GENE TRANSFER; GENE GUN; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HERPES SIMPLEX VIRUS 1; IN VIVO GENE TRANSFER; LOWER URINARY TRACT SYMPTOM; MEDICAL RESEARCH; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OVERACTIVE BLADDER; PERSONALIZED MEDICINE; PRIORITY JOURNAL; STEM CELL; URETER STRICTURE; URETHRA STRICTURE; VIRAL GENE DELIVERY SYSTEM; ANIMAL; EVIDENCE BASED MEDICINE; GENETICS; HUMAN; REVIEW; TREATMENT OUTCOME; URINARY TRACT DISEASE;

ANIMALS; EVIDENCE-BASED MEDICINE; GENE THERAPY; HUMANS; TREATMENT OUTCOME; UROLOGIC DISEASES;

EID: 79952235088     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-16499-6_12     Document Type: Article

References (37)

1. Andersson KE (2009) Pharmacotherapy of the overactive bladder. Discov Med 8:118-124
2. Andersson KE, Appell R, Awad S (2005) Pharmacological treatment of urinary incontinence. In: Abrams P, Khoury S, Wein A (eds) Incontinence, 3rd International Consultation on Incontinence. Helath, Paris, pp 811-854
3. Andersson KE, Chappie CR, Cardozo L, Cruz F, Hashim H, Michel MC, Tannenbaum C, Wein AJ (2009) Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence. Curr Opin Urol 19:380-394
4. Anidjar M, Mongiat-Artus P, Brouland JP, Cochand-Priollet B, Teillac P, Le Due A, Berthon P, Cussenot O (1999) Ureteral gene transfer to porcine induced strictures using endourologic delivery of an adenoviral vector. J Urol 161:1636-1643 (Pubitemid 29420854)
5. Christ GJ (2004) Gene therapy treatments for erectile and bladder dysfunction. Curr Urol Rep 5:52-60
6. Christ GJ, Hodges S (2006) Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction. Br J Pharmacol 147(Suppl 2):S41-S55 (Pubitemid 43239590)
7. Christ GJ, Day NS, Day M, Santizo C, Zhao W, Sclafani T, Zinman J, Hsieh K, Venkateswarlu K, Valcic M, Melman A (2001) Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo. Am J Physiol Regul Integr Comp Physiol 281: R1699-R1709
8. Christ GJ, Day NS, Day M, Zhao W, Persson K, Pandita RK, Andersson KE (2003a) Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo. Am J Physiol Regul Integr Comp Physiol 284:R1241-R1248 (Pubitemid 36457566)
9. Christ GJ, Venkateswarlu K, Day NS, Valcic M, Santizo C, Zhao W, Wang HZ, Persson K, Andersson KE (2003b) Intercellular communication and bladder function. Adv Exp Med Biol 539:239-254 (Pubitemid 38961817)
10. Christ GJ, Hodges S, Melman A (2006) An update on gene therapy/transfer treatments for bladder dysfunction. Curr Bladder Dysfunct Rep 1:119-125
11. Christ G, Andersson KE, Atala A (2007) The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering. Curr Urol Rep 8:95-99 (Pubitemid 46472679)
12. Chuang YC, Chou AK, Wu PC, Chiang PH, Yu TJ, Yang LC, Yoshimura N, Chancellor MB (2003) Gene therapy for bladder pain with gene gun particle encoding pro-opiomelanocortin cDNA. J Urol 170:2044-2048 (Pubitemid 37255005)
13. Fraser MO, Lavelle JP, Sacks MS, Chancellor MB (2002) The future of bladder control-intravesical drug delivery, a pinch of pepper, and gene therapy. Rev Urol 4:1-11
14. Goins WF, Yoshimura N, Phelan MW, Yokoyama T, Fraser MO, Ozawa H, Bennett NJ, de Groat WC, Glorioso JC, Chancellor MB (2001) Herpes simplex virus mediated nerve growth factor expression in bladder and afferent neurons: potential treatment for diabetic bladder dysfunction, J Urol 165:1748-1754 (Pubitemid 32410302)
15. Goins WF, Goss JR, Chancellor MB, de Groat WC, Glorioso JC, Yoshimura N (2009) Herpes simplex virus vector-mediated gene delivery for the treatment of lower urinary tract pain. Gene Ther 16:558-569
16. Hamburg MA, Collins FS (2010) The path to personalized medicine. N Engl J Med 363:301-304
17. Huard J, Yokoyama T, Pruchnic R, Qu Z, Li Y, Lee JY, Somogyi GT, de Groat WC, Chancellor MB (2002) Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction, Gene Ther 9:1617-1626 (Pubitemid 35414524)
18. Johnston J, Baylis F (2004) Gene therapy: two steps forward, one step back. CMAJ 170:1785-1786 (Pubitemid 38833397)
19. Kanai AJ, Zeidel ML, Lavelle JP, Greenberger JS, Birder LA, de Groat WC, Apodaca GL, Meyers SA, Ramage R, Epperly MW (2002) Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis. Am J Physiol Renal Physiol 283:F 1304-F1312
20. Kay MA, High K (1999) Gene therapy for the hemophilias. Proc Natl Acad Sci USA 96:9973-9975 (Pubitemid 29422489)
21. Kay MA, Manno CS, Ragni MV, Larson PJ, Couto LB, McClelland A, Glader B, Chew AJ, Tai SJ, Herzog RW, Arruda V, Johnson F, Scallan C, Skarsgard E, Flake AW, High KA (2000) Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat Genet 24:257-261 (Pubitemid 30132193)
22. Kim S, Lin H, Barr E, Chu L, Leiden JM, Parmacek MS (1997) Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo. J Clin Invest 100:1006-1014 (Pubitemid 27386284)
23. Ku JH, Kim Y, Moon KC, Kim YS, Kim MS, Kim HH, Paick JS (2006) In vivo hepatocyte growth factor gene transfer to bladder smooth muscle after bladder outlet obstruction in the rat: a morphometry analysis. J Urol 176:1230-1235
24. Lu SH, Cannon TW, Chermanski C, Pruchnic R, Somogyi G, Sacks M, de Groat WC, Huard J, Chancellor MB (2003) Muscle-derived stem cells seeded into acellular scaffolds develop calcium-dependent contractile activity that is modulated by nicotinic receptors, Urology 61:1285-1291 (Pubitemid 36694034)
25. Marshall E (2001) Gene therapy. Viral vectors still pack surprises. Science 294:1640
26. Melman A, Bar-Chama N, McCullough A, Davies K, Christ G (2005) The first human trial for gene transfer therapy for the treatment of erectile dysfunction: preliminary results. Eur Urol 48:314-318 (Pubitemid 40957111)
27. Meria P, Anidjar M, Brouland JP, Teillac P, Berthon P, Cussenot O (2000) Gene transfer to urethral strictures in rabbits: a preliminary report. BJU Int 85:1120-1125 (Pubitemid 30348812)
28. Miyazato M, Sugaya K, Goins WF, Wolfe D, Goss JR, Chancellor MB, de Groat WC, Glorioso JC, Yoshimura N (2009) Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats. Gene Ther 16:660-668
29. Morgan RA, Anderson WF (1993) Human gene therapy. Annu Rev Biochem 62:191-217 (Pubitemid 23237870)
30. Otani M, Yoshida M, Iwashita H, Kawano Y, Miyamae K, Inadome A, Nishi T, Ueda S (2004) Electroporati on-mediated muscarinic M3 receptor gene transfer into rat urinary bladder. Int J Urol 11:1001-1008 (Pubitemid 39577197)
31. Pattee SR (2008) Protections for participants in gene therapy trials: a patient's perspective. Hum Gene Ther 19:9-10
32. Sasaki K, Chancellor MB, Goins WF, Phelan MW, Glorioso JC, de Groat WC, Yoshimura N (2004) Gene therapy using replication-defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy. Diabetes 53:2723-2730 (Pubitemid 39299286)
33. Tyagi S, Tyagi P, Van-le S, Yoshimura N, Chancellor MB, de Miguel F (2006) Qualitative and quantitative expression profile of muscarinic receptors in human urothelium and detrusor, J Urol 176:1673-1678 (Pubitemid 44307245)
34. Yokoyama T, Chancellor MB, Yoshimura N, Huard J, Kumon H (2001) Gene therapy and tissue engineering for urologie dysfunction: status and prospects. Mol Urol 5:67-70 (Pubitemid 32448698)
35. Yokoyama H, Sasaki K, Franks ME, Goins WF, Goss JR, de Groat WC, Glorioso JC, Chancellor MB, Yoshimura N (2009a) Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin. Hum Gene Ther 20:63-71
36. Yokoyama H, Sasaki K, Franks ME, Goins WF, Goss JR, Degroat WC, Glorioso J, Chancellor MB, Yoshimura N (2009b) Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin. Hum Gene Ther 20:63-71
37. Yoshimura N, Franks ME, Sasaki K, Goins WF, Goss J, Yokoyama T, Fraser MO, Seki S, Fink J, Glorioso J, de Groat WC, Chancellor MB (2001) Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE). Urology 57:116