Small molecule inhibitors of staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis

PLoS Pathogens

Volumn 7, Issue 2, 2011, Pages

  Olson, Patrick D ^a   Kuechenmeister, Lisa J ^a   Anderson, Kelsi L ^a   Daily, Sonja ^b   Beenken, Karen E ^b   Roux, Christelle M ^a   Reniere, Michelle L ^c   Lewis, Tami L ^a   Weiss, William J ^d   Pulse, Mark ^d   Nguyen, Phung ^d   Simecka, Jerry W ^d   Morrison, John M ^a   Sayood, Khalid ^e   Asojo, Oluwatoyin A ^a   Smeltzer, Mark S ^b   Skaar, Eric P ^c   Dunman, Paul M ^a,f  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^e UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^f UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; MESSENGER RNA; RIBONUCLEASE P; RIBOSOME RNA; RNPA 1000; RNPA PROTEIN; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; BACTERIAL VIRULENCE; BIOFILM; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DOSE COMPARISON; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; FEMALE; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; RNA DEGRADATION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; ANIMAL; BIOLOGICAL MODEL; CELL STRAIN HEPG2; DRUG ANTAGONISM; DRUG EFFECT; EVALUATION; GENETICS; METABOLISM; MOLECULAR LIBRARY; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; RNA PROCESSING; VIRULENCE;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-INFECTIVE AGENTS; FEMALE; HEP G2 CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; RIBONUCLEASE P; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; SMALL MOLECULE LIBRARIES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN; VIRULENCE;

EID: 79952233550     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001287     Document Type: Article

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