Warfarin Toxicity and Individual Variability-Clinical Case

Toxins

Volumn 2, Issue 11, 2010, Pages 2584-2592

  Piatkov, Irina ^a   Rochester, Colin ^a   Jones, Trudi ^a   Boyages, Steven ^a  

^a WESTMEAD HOSPITAL   (Australia)

Author keywords

Anticoagulant; Pesticides; Warfarin

Indexed keywords

CYTOCHROME P450 2C9; SERTRALINE; WARFARIN;

ADULT; ANTICOAGULATION; ARTICLE; BLEEDING; CASE REPORT; DEEP VEIN THROMBOSIS; DNA POLYMORPHISM; FEMALE; GENETIC SCREENING; HUMAN; PHARMACOGENETICS; RISK FACTOR;

ANTICOAGULANTS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERNATIONAL NORMALIZED RATIO; MIDDLE AGED; PHARMACOGENETICS; POLYMORPHISM, GENETIC; VENOUS THROMBOSIS; WARFARIN;

MUS; RATTUS;

EID: 79952230180     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins2112584     Document Type: Article

References (40)

1. Makris, M.; Watson, H.G. The management of coumarin-induced over-anticoagulation Annotation. Br. J. Haematol. 2001, 114, 271-280.
2. King, B.P.; Khan, T.I.; Aithal, G.P.; Kamali, F.; Daly, A.K. Upstream and coding region CYP2C9 polymorphisms: Correlation with warfarin dose and metabolism. Pharmacogenetics 2004, 14, 813-822.
3. Gage, B.F.; Lesko, L.J. Pharmacogenetics of warfarin: Regulatory, scientific, and clinical issues. J. Thromb. Thrombolysis 2008, 25, 45-51.
4. Palareti, G.; Leali, N.; Coccheri, S.; Poggi, M.; Manotti, C.; D'Angelo, A.; Pengo, V.; Erba, N.; Moia, M.; Ciavarella, N.; Devoto, G.; Berretini, M.; Musolesi, S. Hemorrhagic complications of oral anticoagulant therapy: Results of a prospective multicenter study ISCOAT (Italian Study on Complications of Oral Anticoagulant Therapy). G. Ital. Cardiol. 1997, 27, 231-243.
5. Hirsh, J.; Bates, S.M. Clinical trials that have influenced the treatment of venous thromboembolism: A historical perspective. Ann. Intern. Med. 2001, 134, 409-417.
6. Hirsh, J.; Dalen, J.; Anderson, D.R.; Poller, L.; Bussey, H.; Ansell, J.; Deykin, D. Oral anticoagulants: Mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 2001, 119, 8S-21S.
7. Jones, D.R.; Kim, S.Y.; Guderyon, M.; Yun, C.H.; Moran, J.H.; Miller, G.P. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem. Res. Toxicol. 2010, 23, 939-945.
8. Kamali, F.; Wynne, H. Pharmacogenetics of warfarin. Annu. Rev. Med. 2010, 61, 63-75.
9. Kaminsky, L.S.; Zhang, Z.Y. Human P450 metabolism of warfarin. Pharmacol. Ther. 1997, 73, 67-74.
10. Adcock, D.M.; Koftan, C.; Crisan, D.; Kiechle, F.L. Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation. Arch. Pathol. Lab. Med. 2004, 128, 1360-1363.
11. Takahashi, H.; Echizen, H. Pharmacogenetics of warfarin elimination and its clinical implications. Clin. Pharmacokinet. 2001, 40, 587-603.
12. Rettie, A.E.; Wienkers, L.C.; Gonzalez, F.J.; Trager, W.F.; Korzekwa, K.R. Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9. Pharmacogenetics 1994, 4, 39-42.
13. Haining, R.L.; Hunter, A.P.; Veronese, M.E.; Trager, W.F.; Rettie, A.E. Allelic variants of human cytochrome P450 2C9: Baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms. Arch. Biochem. Biophys. 1996, 333, 447-458.
14. Steward, D.J.; Haining, R.L.; Henne, K.R.; Davis, G.; Rushmore, T.H.; Trager, W.F.; Rettie, A.E. Genetic association between sensitivity to warfarin and expression of CYP2C93. Pharmacogenetics 1997, 7, 361-367.
15. Margaglione, M.; Colaizzo, D.; D'Andrea, G.; Brancaccio, V.; Ciampa, A.; Grandone, E.; Di Minno, G. Genetic modulation of oral anticoagulation with warfarin. Thromb. Haemost. 2000, 84, 775-778.
16. Scordo, M.G.; Pengo, V.; Spina, E.; Dahl, M.L.; Gusella, M.; Padrini, R. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin. Pharmacol. Ther. 2002, 72, 702-710.
17. Visser, L.E.; van Vliet, M.; van Schaik, R.H.; Kasbergen, A.A.; De Smet, P.A.; Vulto, A.G.; Hofman, A.; van Duijn, C.M.; Stricker, B.H. The risk of overanticoagulation in patients with cytochrome P450 CYP2C92 or CYP2C93 alleles on acenocoumarol or phenprocoumon. Pharmacogenetics 2004, 14, 27-33.
18. Wang, B.; Wang, J.; Huang, S.Q.; Su, H.H.; Zhou, S.F. Genetic Polymorphism of the Human Cytochrome P450 2C9 Gene and Its Clinical Significance. Curr. Drug. Metab. 2009, 10, 781-834.
19. Furuya, H.; Fernandez-Salguero, P.; Gregory, W.; Taber, H.; Steward, A.; Gonzalez, F.J.; Idle, J.R. Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy. Pharmacogenetics 1995, 5, 389-392.
20. Aithal, G.P.; Day, C.P.; Kesteven, P.J.; Daly, A.K. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 1999, 353, 717-719.
21. Higashi, M.K.; Veenstra, D.L.; Kondo, L.M.; Wittkowsky, A.K.; Srinouanprachanh, S.L.; Farin, F.M.; Rettie, A.E. Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA 2002, 287, 1690-1698.
22. Tabrizi, A.R.; Zehnbauer, B.A.; Borecki, I.B.; McGrath, S.D.; Buchman, T.G.; Freeman, B.D. The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin. J. Am. Coll. Surg. 2002, 194, 267-273.
23. Taube, J.; Halsall, D.; Baglin, T. Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment. Blood 2000, 96, 1816-1819.
24. Wadelius, M.; Sorlin, K.; Wallerman, O.; Karlsson, J.; Yue, Q.Y.; Magnusson, P.K.; Wadelius, C.; Melhus, H. Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors. Pharmacogenomics J. 2004, 4, 40-48.
25. Freeman, B.D.; Zehnbauer, B.A.; McGrath, S.; Borecki, I.; Buchman, T.G. Cytochrome P450 polymorphisms are associated with reduced warfarin dose. Surgery 2000, 128, 281-285.
26. Takahashi, H.; Echizen, H. Pharmacogenetics of CYP2C9 and interindividual variability in anticoagulant response to warfarin. Pharmacogenomics J. 2003, 3, 202-214.
27. London, S.J.; Daly, A.K.; Leathart, J.B.; Navidi, W.C.; Idle, J.R. Lung cancer risk in relation to the CYP2C91/CYP2C92 genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California. Pharmacogenetics 1996, 6, 527-533.
28. Nasu, K.; Kubota, T.; Ishizaki, T. Genetic analysis of CYP2C9 polymorphism in a Japanese population. Pharmacogenetics 1997, 7, 405-409.
29. Bhasker, C.R.; Miners, J.O.; Coulter, S.; Birkett, D.J. Allelic and functional variability of cytochrome P4502C9. Pharmacogenetics 1997, 7, 51-58.
30. Schalekamp, T.; Klungel, O.H.; Souverein, P.C.; de Boer, A. Increased bleeding risk with concurrent use of selective serotonin reuptake inhibitors and coumarins. Arch. Intern. Med. 2008, 168, 180-185.
31. Dalton, S.O.; Sorensen, H.T.; Johansen, C. SSRIs and upper gastrointestinal bleeding: What is known and how should it influence prescribing? CNS Drugs 2006, 20, 143-151.
32. Meijer, W.E.; Heerdink, E.R.; Leufkens, H.G.; Herings, R.M.; Egberts, A.C.; Nolen, W.A. Incidence and determinants of long-term use of antidepressants. Eur. J. Clin. Pharmacol. 2004, 60, 57-61.
33. Greenblatt, D.J.; von Moltke, L.L.; Harmatz, J.S.; Shader, R.I. Drug interactions with newer antidepressants: Role of human cytochromes P450. J. Clin. Psychiatry 1998, 59 (Suppl. 15), 19-27.
34. DeVane, C.L. Differential pharmacology of newer antidepressants. J. Clin. Psychiatry 1998, 59 (Suppl. 20), 85-93.
35. Hauta-Aho, M.; Tirkkonen, T.; Vahlberg, T.; Laine, K. The effect of drug interactions on bleeding risk associated with warfarin therapy in hospitalized patients. Ann. Med. 2009, 41, 619-628.
36. Wallerstedt, S.M.; Gleerup, H.; Sundstrom, A.; Stigendal, L.; Ny, L. Risk of clinically relevant bleeding in warfarin-treated patients-influence of SSRI treatment. Pharmacoepidemiol. Drug Saf. 2009, 18, 412-416.
37. Wessinger, S.; Kaplan, M.; Choi, L.; Williams, M.; Lau, C.; Sharp, L.; Crowell, M.D.; Keshavarzian, A.; Jones, M.P. Increased use of selective serotonin reuptake inhibitors in patients admitted with gastrointestinal haemorrhage: A multicentre retrospective analysis. Aliment. Pharmacol. Ther. 2006, 23, 937-944.
38. Duncan, D.; Sayal, K.; McConnell, H.; Taylor, D. Antidepressant interactions with warfarin. Int. Clin. Psychopharmacol. 1998, 13, 87-94.
39. Sayal, K.S.; Duncan-McConnell, D.A.; McConnell, H.W.; Taylor, D.M. Psychotropic interactions with warfarin. Acta Psychiatr. Scand. 2000, 102, 250-255.
40. Apseloff, G.; Wilner, K.D.; Gerber, N.; Tremaine, L.M. Effect of sertraline on protein binding of warfarin. Clin. Pharmacokinet. 1997, 32 (Suppl. 1), 37-42.