Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 44, Issue 3, 2011, Pages 404-414

  Maguire, Jean Ann ^a   Mulugeta, Surafel ^a   Beers, Michael F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

ER stress; Interleukin 8; Interstitial lung disease; Surfactant proteins; Unfolded protein response

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; HOMOCYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MUTANT PROTEIN; PROTEASOME; PROTEIN HERPUD1; STRESS ACTIVATED PROTEIN KINASE; SURFACTANT PROTEIN C; UBIQUITIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; INTERSTITIAL LUNG DISEASE; PHENOTYPE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

CELL LINE; CELL LINE, TUMOR; CYTOKINES; ENDOPLASMIC RETICULUM; EPITHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-8; LUNG DISEASES, INTERSTITIAL; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; NF-KAPPA B; POLYMERASE CHAIN REACTION; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; SIGNAL TRANSDUCTION;

EID: 79952219426     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0382OC     Document Type: Article

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