Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells

Oncology Reports

Volumn 25, Issue 4, 2011, Pages 979-987

  Li, Jingjie ^a   Zhu, Wenbo ^a   Leng, Tiandong ^a   Shu, Minfeng ^a   Huang, Yijun ^a   Xu, Dong ^a   Qiu, Pengxin ^a   Su, Xingwen ^a   Yan, Guangmei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Renal cell carcinoma; Triptolide

Indexed keywords

CASPASE 3; CASPASE 8; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; RETINOBLASTOMA PROTEIN; TRIPTOLIDE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CARCINOMA, RENAL CELL; CASPASES; CELL CYCLE; CYTOCHROMES C; DITERPENES; EPOXY COMPOUNDS; HUMANS; KIDNEY NEOPLASMS; MITOCHONDRIA; PHENANTHRENES; TUMOR CELLS, CULTURED;

EID: 79952217807     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1158     Document Type: Article

References (53)

1. Wood LS: Renal cell carcinoma: Screening, diagnosis, and prognosis. Clin J Oncol Nurs 13 (Suppl.): S3-S7, 2009.
2. Ather MH, Masood N and Siddiqui T: Current management of advanced and metastatic renal cell carcinoma. Urol J 7: 1-9, 2010.
3. Zigeuner R and Pummer K: [Current surgical aspects of renal cell carcinoma]. Wien Med Wochenschr 159: 535-542, 2009.
4. Basso M, Cassano A and Barone C: A survey of therapy for advanced renal cell carcinoma. Urol Oncol 28: 121-133, 2010.
5. Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348, 2001. (Pubitemid 32467043)
6. Senderowicz AM: Targeting cell cycle and apoptosis for the treatment of human malignancies. Curr Opin Cell Biol 16: 670-678, 2004.
7. Liu DX and Greene LA: Neuronal apoptosis at the g1/s cell cycle checkpoint. Cell Tissue Res 305: 217-228, 2001. (Pubitemid 32681898)
8. Philipson L: Cell cycle exit: Growth arrest, apoptosis, and tumor suppression revisited. Mol Med 4: 205-213, 1998.
9. Pietenpol JA and Stewart ZA: Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis. Toxicology 181-182: 475-481, 2002. (Pubitemid 36015741)
10. Dittmann H, Dohmen BM, Kehlbach R, et al: Early changes in [18f]flt uptake after chemotherapy: An experimental study. Eur J Nucl Med Mol Imaging 29: 1462-1469, 2002. (Pubitemid 35232048)
11. McCormack ES, Borzillo GV, Ambrosino C, et al: Transforming growth factor-beta3 protection of epithelial cells from cycle-selective chemotherapy in vitro. Biochem Pharmacol 53: 1149-1159, 1997. (Pubitemid 27224261)
12. Long HJ: Paclitaxel (taxol): A novel anticancer chemotherapeutic drug. Mayo Clin Proc 69: 341-345, 1994.
13. Wang JL, Gunther GR and Edelman GM: Inhibition by colchicine of the mitogenic stimulation of lymphocytes prior to the S phase. J Cell Biol 66: 128-144, 1975.
14. Chen BJ: Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb tripterygium wilfordii hook f. Leuk Lymphoma 42: 253-265, 2001.
15. Gu WZ, Chen R, Brandwein S, McAlpine J and Burres N: Isolation, purification, and characterization of immunosuppressive compounds from tripterygium: Triptolide and tripdiolide. Int J Immunopharmacol 17: 351-356, 1995.
16. Chang WT, Kang JJ, Lee KY, et al: Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway. J Biol Chem 276: 2221-2227, 2001. (Pubitemid 32109705)
17. Yang S, Chen J, Guo Z, et al: Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther 2: 65-72, 2003.
18. Fidler JM, Li K, Chung C, et al: Pg490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. Mol Cancer Ther 2: 855-862, 2003.
19. Zhu W, Ou Y, Li Y, et al: A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway. Mol Pharmacol 75: 812-819, 2009.
20. Green DR: Apoptotic pathways: Paper wraps stone blunts scissors. Cell 102: 1-4, 2000.
21. Nagata S: Apoptosis by death factor. Cell 88: 355-365, 1997.
22. Kroemer G and Reed JC: Mitochondrial control of cell death. Nat Med 6: 513-519, 2000. (Pubitemid 30305900)
23. Reed JC: Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med 7: 314-319, 2001.
24. Kuwana T and Newmeyer DD: Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 15: 691-699, 2003. (Pubitemid 37487962)
25. Gross A, McDonnell JM and Korsmeyer SJ: Bcl-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999.
26. Sherr CJ: G1 phase progression: Cycling on cue. Cell 79: 551-555, 1994.
27. Sherr CJ: The ins and outs of Rb: Coupling gene expression to the cell cycle clock. Trends Cell Biol 4: 15-18, 1994.
28. Grana X and Reddy EP: Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (cdks), growth suppressor genes and cyclin-dependent kinase inhibitors (ckis). Oncogene 11: 211-219, 1995.
29. Kobayashi H: [Mitotic cyclins and mpf]. Tanpakushitsu Kakusan Koso 38: 2293-2301, 1993.
30. Garcia JA, Cowey CL and Godley PA: Renal cell carcinoma. Curr Opin Oncol 21: 266-271, 2009.
31. Bolton DM, Wong P and Lawrentschuk N: Renal cell carcinoma: Imaging and therapy. Curr Opin Urol 17: 337-340, 2007. (Pubitemid 47344621)
32. Sherr CJ: Growth factor-regulated g1 cyclins. Stem Cells 12 (Suppl 1): 47-55, 1994.
33. Sherr CJ, Kato J, Quelle DE, Matsuoka M and Roussel MF: D-type cyclins and their cyclin-dependent kinases: G1 phase integrators of the mitogenic response. Cold Spring Harb Symp Quant Biol 59: 11-19, 1994.
34. Shakoori AR, van Wijnen AJ, Cooper C, et al: Cytokine induction of proliferation and expression of cdc2 and cyclin a in fdc-p1 myeloid hematopoietic progenitor cells: Regulation of ubiquitous and cell cycle-dependent histone gene transcription factors. J Cell Biochem 59: 291-302, 1995.
35. Maller JL: Mpf and cell cycle control. Adv Second Messenger Phosphoprotein Res 24: 323-328, 1990.
36. Masui Y: [Regulations of cell division cycles and mpf]. Tanpakushitsu Kakusan Koso 38: 2285-2291, 1993.
37. Wan CK, Wang C, Cheung HY, Yang M and Fong WF: Triptolide induces bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient hl-60 cells. Cancer Lett 241: 31-41, 2006.
38. Kiviharju TM, Lecane PS, Sellers RG and Peehl DM: Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res 8: 2666-2674, 2002. (Pubitemid 34856355)
39. Liu J, Jiang Z, Xiao J, et al: Effects of triptolide from tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. Phytomedicine 16: 1006-1013, 2009.
40. Jiang XH, Wong BC, Lin MC, et al: Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene 20: 8009-8018, 2001. (Pubitemid 34001562)
41. Zhao F, Chen Y, Li R, Liu Y, Wen L and Zhang C: Triptolide alters histone H3K9 and H3K27 methylation state, and induces G0/G1 arrest and caspase-dependent apoptosis, in multiple myeloma in vitro. Toxicology 267: 70-79, 2009.
42. Su Y, Yang S, Xiao Z, Wang W, Okunieff P and Zhang L: Triptolide alters mitochondrial functions. Adv Exp Med Biol 599: 139-146, 2007.
43. Carter BZ, Mak DH, Schober WD, et al: Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 108: 630-637, 2006. (Pubitemid 44061364)
44. Jin Y, Chen Q, Shi X, et al: Activity of triptolide against human mast cells harboring the kinase domain mutant kit. Cancer Sci 100: 1335-1343, 2009.
45. Shi X, Jin Y, Cheng C, et al: Triptolide inhibits bcr-abl transcription and induces apoptosis in sti571-resistant chronic myelogenous leukemia cells harboring t315i mutation. Clin Cancer Res 15: 1686-1697, 2009.
46. Wang X, Matta R, Shen G, Nelin LD, Pei D and Liu Y: Mechanism of triptolide-induced apoptosis: Effect on caspase activation and bid cleavage and essentiality of the hydroxyl group of triptolide. J Mol Med 84: 405-415, 2006. (Pubitemid 43673615)
47. Yao J, Jiang Z, Duan W, et al: Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver 1-02 cells. Biol Pharm Bull 31: 592-597, 2008. (Pubitemid 351500486)
48. Lin J, Chen LY, Lin ZX and Zhao ML: The effect of triptolide on apoptosis of glioblastoma multiforme (GBM) cells. J Int Med Res 35: 637-643, 2007. (Pubitemid 47570485)
49. Chiarugi V, Magnelli L and Cinelli M: Complex interplay among apoptosis factors: Rb, p53, E2F, TGF-beta, cell cycle inhibitors and the bcl2 gene family. Pharmacol Res 35: 257-261, 1997. (Pubitemid 27331182)
50. Harbour JW and Dean DC: Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2: E65-E67, 2000.
51. DeGregori J and Johnson DG: Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 6: 739-748, 2006. (Pubitemid 44725567)
52. Eischen CM, Packham G, Nip J, et al: Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1. Oncogene 20: 6983-6993, 2001. (Pubitemid 33052191)
53. Yang HL, Dong YB, Elliott MJ, Liu TJ and McMasters KM: Caspase activation and changes in bcl-2 family member protein expression associated with E2F-1-mediated apoptosis in human esophageal cancer cells. Clin Cancer Res 6: 1579-1589, 2000. (Pubitemid 30226249)