Autism severity is associated with child and maternal MAOA genotypes

Clinical Genetics

Volumn 79, Issue 4, 2011, Pages 355-362

  Cohen, I L ^a   Liu, X ^b,c   Lewis, M E S ^d   Chudley, A ^e   Forster Gibson, C ^b   Gonzalez, M ^a   Jenkins, E C ^a   Brown, Wt ^a   Holden, J J A ^b,c  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b QUEEN S UNIVERSITY   (Canada)

^c Department of Physiology   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Autism; Autism severity; MAOA; Maternal effects; UVNTR

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A;

ADOLESCENT; AGGRESSION; ALLELE; ARTICLE; AUTISM; CHILD; COMMUNICATION SKILL; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; GENE REPLICATION; GENETIC ASSOCIATION; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTHER; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; SCHOOL CHILD; VARIABLE NUMBER OF TANDEM REPEAT;

ADOLESCENT; ANALYSIS OF VARIANCE; AUTISTIC DISORDER; CHILD; CHILD BEHAVIOR DISORDERS; CHILD, PRESCHOOL; GENOTYPE; HUMANS; MALE; MINISATELLITE REPEATS; MONOAMINE OXIDASE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC;

EID: 79952213669     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/j.1399-0004.2010.01471.x     Document Type: Article

References (46)

1. Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 1998: 103: 273-279.
2. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993: 262: 578-580.
3. Buckholtz JW, Meyer-Lindenberg A. MAOA and the neurogenetic architecture of human aggression. Trends Neurosci 2008: 31: 120-129.
4. Caspi A, McClay J, Moffitt TE et al. Role of genotype in the cycle of violence in maltreated children. Science 2002: 297: 851-854.
5. Cerasa A, Gioia MC, Fera F et al. Ventro-lateral prefrontal activity during working memory is modulated by MAO A genetic variation. Brain Res 2008: 1201: 114-21.
6. Contini V, Marques FZ, Garcia CE, Hutz MH, Bau CH. MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 2006: 141B: 305-308.
7. Courtet P, Jollant F, Buresi C, Castelnau D, Mouthon D, Malafosse A. The monoamine oxidase A gene may influence the means used in suicide attempts. Psychiatr Genet 2005: 15: 189-193.
8. Dannlowski U, Ohrmann P, Konrad C et al. Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity. Int J Neuropsychopharmacol 2009: 12: 11-22.
9. Davis LK, Hazlett HC, Librant AL et al. Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene. Am J Med Genet B Neuropsychiatr Genet 2008: 5: 1145-1151.
10. Deckert J, Catalano M, Syagailo YV et al. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 1999: 8: 621-624.
11. Denney RM, Koch H, Craig IW. Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat. Hum Genet 1999: 105: 542-551.
12. Domschke K, Hohoff C, Mortensen LS et al. Monoamine oxidase A variant influences antidepressant treatment response in female patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2008: 32: 224-228.
13. Du L, Bakish D, Ravindran A, Hrdina PD. MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males. Neuroreport 2004: 15: 2097-2101.
14. Herman AI, Kaiss KM, Ma R et al. Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women. Am J Med Genet B Neuropsychiatr Genet 2005: 133B: 74-78.
15. Huang YY, Cate SP, Battistuzzi C, Oquendo MA, Brent D, Mann JJ. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology 2004: 29: 1498-1505.
16. Kinnally EL, Huang YY, Haverly R et al. Parental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult women. Psychiatr Genet 2009: 19: 126-133.
17. Malmberg K, Wargelius HL, Lichtenstein P, Oreland L, Larsson JO. ADHD and Disruptive Behavior scores - associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents. BMC Psychiatry 2008: 28: 1-9.
18. Manuck SB, Flory JD, Ferrell RE, Mann JJ, Muldoon MF. A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res 2000: 95: 9-23.
19. Maron E, Lang A, Tasa G et al. Associations between serotonin-related gene polymorphisms and panic disorder. Int J Neuropsychopharmacol 2005: 8: 261-266.
20. May ME, Srour A, Hedges LK et al. Monoamine oxidase a promoter gene associated with problem behavior in adults with intellectual/developmental disabilities. Am J Intellect Dev Disabil 2009: 114: 269-273.
21. Passamonti L, Fera F, Magariello A et al. Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity. Biol Psychiatry 2006: 59: 334-340.
22. Roohi J, DeVincent CJ, Hatchwell E, Gadow KD. Association of a monoamine oxidase-a gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder. J Autism Dev Disord 2009: 39: 67-74.
23. Sjoberg RL, Ducci F, Barr CS et al. A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. Neuropsychopharmacology 2008: 33: 425-430.
24. Widom CS, Brzustowicz LM. MAOA and the "cycle of violence:" childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biol Psychiatry 2006: 60: 684-689.
25. Williams RB, Marchuk DA, Gadde KM et al. A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Neuropsychopharmacology 2003: 28: 533-541.
26. Treister R, Pud D, Ebstein RP et al. Associations between polymorphisms in dopamine neurotransmitter pathway genes and pain response in healthy humans. Pain 2009: 147: 187-193.
27. Meyer-Lindenberg A, Buckholtz JW, Kolachana B et al. Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A 2006: 103: 6269-6274.
28. Brummett BH, Boyle SH, Siegler IC et al. HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR). Biol Psychol 2008: 79: 250-255.
29. Schulze TG, Muller DJ, Krauss H et al. Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. Am J Med Genet 2000: 96: 801-803.
30. Yu YW, Tsai SJ, Hong CJ, Chen TJ, Chen MC, Yang CW. Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology 2005: 30: 1719-1723.
31. Cohen IL, Liu X, Schutz C et al. Association of autism severity with a monoamine oxidase A functional polymorphism. Clin Genet 2003: 64: 190-197.
32. Slavotinek A, Biesecker LG. Genetic modifiers in human development and malformation syndromes, including chaperone proteins. Human Molecular Genetics 2003: 12: R45-R50.
33. Cohen IL, Schmidt-Lackner S, Romanczyk R, Sudhalter V. The PDD Behavior Inventory: A rating scale for assessing response to intervention in children with PDD. J Autism Dev Disord 2003: 33: 31-45.
34. Cohen IL. Criterion-Related Validity of the PDD Behavior Inventory. J Autism Dev Disord 2003: 33: 47-53.
35. Cohen IL, Sudhalter V. The PDD behavior inventory. Lutz, FL: Psychological Assessment Resources, Inc., 2005.
36. Liu X, Novosedlik N, Wang A et al. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. Eur J Hum Genet 2009: 17: 228-235.
37. Banach R, Thompson A, Szatmari P et al. Brief report: relationship between non-verbal IQ and gender in autism. J Autism Dev Disord 2009: 39: 188-193.
38. Virkud YV, Todd RD, Abbacchi AM, Zhang Y, Constantino JN. Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. Am J Med Genet B Neuropsychiatr Genet 2009: 150B: 328-334.
39. Jones MB, Palmour RM, Zwaigenbaum L, Szatmari P. Modifier effects in autism at the MAO-A and DBH loci. Am J Med Genet B Neuropsychiatr Genet 2004: 126B: 58-65.
40. Lord C, Risi S, Lambrecht L et al. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 2000: 30: 205-223.
41. Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994: 24: 659-685.
42. Cohen IL, Gomez TR, Gonzalez MG, Lennon EM, Karmel BZ, Gardner JM. Parent PDD behavior inventory profiles of young children classified according to autism diagnostic observation schedule-generic and autism diagnostic interview-revised criteria. J Autism Dev Disord 2010: 40: 246-254.
43. StatSoft. Statistica 9.0. Tulsa, OK: StatSoft, 2009.
44. Cohen IL, Tsiouris J. Maternal recurrent mood disorders and high-functioning autism. J Autism Dev Disord 2006: 36: 1077-1088.
45. Cote F, Fligny C, Bayard E et al. Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci U S A 2007: 329-334.
46. Guimaraes AP, Zeni C, Polanczyk G et al. MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder. Int J Neuropsychopharmacol 2009: 12: 709-714.