Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound

Oncology Reports

Volumn 25, Issue 4, 2011, Pages 905-913

  Hoshi, Hirotaka ^a   Saito, Hikaru ^a   Iijima, Hiroko ^a   Uchida, Motoyuki ^a   Wada, Tsutomu ^a   Ito, Gentaro ^b   Tanaka, Hiroaki ^b   Sawada, Tetsuji ^b   Hirakawa, Kosei ^b  

^a KUREHA CORPORATION   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Coriolus versicolor; Glucan; Monoclonal antibody; Polysaccharide; Protein bound polysaccharide K

Indexed keywords

KRESTIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2G9; MONOCLONAL ANTIBODY 5G5; PROTEIN ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOSTASIS; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG TISSUE LEVEL; FEMALE; FIBROSARCOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSARCOMA; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, SCID; PROTEOGLYCANS; TUMOR CELLS, CULTURED;

EID: 79952211593     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1155     Document Type: Article

References (19)

1. Ebina T and Kohya H: Antitumor effector mechanism at a distant site in the double grafted tumor system of PSK, a protein-bound polysaccharide preparation. Cancer Sci 79: 957-964, 1988.
2. Harada M, Matsunaga K, Oguchi Y, et al: The involvement of transforming growth factor beta in the impaired antitumor T-cell response at the gut-associated lymphoid tissue (GALT). Cancer Res 55: 6146-6151, 1995.
3. + T-cell response in gut-associated lymphoid tissue (GALT) of specific-pathogen-free mice. Int J Cancer 70: 362-372, 1997. (Pubitemid 27099608)
4. Hirose K, Zachariae CO, Oppenheim JJ and Matsushima K: Induction of gene expression and production of immunomodulating cytokines by PSK in human peripheral blood mononuclear cells. Lymphokine Res 9: 475-483, 1990. (Pubitemid 20384838)
5. Kariya Y, Okamoto N, Fujimoto T, et al: Lysis of fresh human tumor cells by autologous peripheral blood lymphocytes and tumor-infiltrating lymphocytes activated by PSK. Cancer Sci 82: 1044-1050, 1991.
6. Matsunaga K, Hosokawa A, Oohara M, Sugita N, Harada M and Nomoto K: Direct action of a protein-bound polysaccharide, PSK, on transforming growth factor-β. Immunopharmacology 40: 219-230, 1998. (Pubitemid 28522180)
7. Pedrinaci S, Algarra I and Garrido F: Protein-bound polysaccharide (PSK) induces cytotoxic activity in the NKL human natural killer cell line. Int J Clin Lab Res 29: 135-140, 1999.
8. Sugiyama Y, Saji S, Kato M, Yasuda K and Adachi T: Basic and clinical studies on antitumor mechanism of PSK. J Immunother 20: 412, 1997.
9. Wada T, Wakamatsu Y, Bannai K, et al: Suppression mechanism of angiogenesis PSK. Ann Cancer Res Ther 10: 93-106, 2002.
10. Yefenof E: Apoptosis in the immune system and cancer: common denominators and bilateral implications. Biotherapy 12: 1-5, 1998.
11. Yefenof E, Gafanovitch I, Oron E, Bar M and Klein E: Prophylactic intervention in radiation-leukemia-virus-induced murine lymphoma by the biological response modifier polysaccharide K. Cancer Immunol Immunother 41: 389-396, 1995. (Pubitemid 26045108)
12. Zhang H, Morisaki T, Matsunaga H, et al: Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-beta1 and MMPs. Clin Exp Metastasis 18: 343-352, 2000. (Pubitemid 32579404)
13. Zhang H, Morisaki T, Nakahara C, et al: PSK-mediated NF-kappaB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1. Oncogene 22: 2088-2096, 2003. (Pubitemid 36539559)
14. Endoh H, Matsunaga K, Yoshikumi C, Kawai Y, Suzuki T and Nomoto K: Production of antiserum against antitumor protein-bound polysaccharide preparation, PSK (Krestin) and its pharmacological application. Int J Immunopharmacol 10: 103-109, 1988. (Pubitemid 18085539)
15. Yosizawa Z, Sato T and Schmid K: Hydrazinolysis of alpha-1-acid glycoprotein. Biochim Biophys Acta 121: 417-420, 1966.
16. Hoshi H, Iijima H, Yagi Y, Matsunaga K, Ishihara Y and Yasuhara T: Isolation and characterization of a novel immunomodulatory α-glucan- protein complex from the mycelium of Tricholoma matsutake in basidiomycetes. J Agric Food Chem 53: 8948-8956, 2005. (Pubitemid 41735657)
17. Janek P, Briand P and Hartman NR: The effect of estrone-progesterone treatment on cell proliferation kinetics of hormone-dependent GR mouse mammary tumors. Cancer Res 35: 3698-3704, 1975.
18. Hirata A, Adachi Y, Itoh W, Komoda M, Tabata K and Sugawara I: Monoclonal antibody to proteoglycan derived from Grifola frondosa (Maitake). Biol Pharm Bull 17: 539-542, 1994. (Pubitemid 24146614)
19. Ikuzawa M, Matsunaga K, Nishiyama S, et al: Fate and distribution of an antitumor protein-bound polysaccharide PSK (Krestin). Int J Immunopharmacol 10: 415-423, 1988.