Hyperproliferation markers in ear canal epidermis

Brazilian Journal of Otorhinolaryngology

Volumn 76, Issue 5, 2010, Pages 667-671

  Gurgel, João Daniel Caliman e ^a   Pereira, Celina Siqueira Barbosa ^a   Alves, Adriana Leal ^a   Ribeiro, Fernando Quintanilha ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cholesteatoma; Ear canal; Immunohistochemistry; Keratins

Indexed keywords

BIOLOGICAL MARKER; CYCLINE; CYTOKERATIN 16; KI 67 ANTIGEN;

AUDITORY CANAL; CELL PROLIFERATION; CHOLESTEATOMA; EARDRUM; EPIDERMIS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; REVIEW;

BIOLOGICAL MARKERS; CELL PROLIFERATION; CHOLESTEATOMA, MIDDLE EAR; EAR CANAL; EPIDERMIS; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-16; KI-67 ANTIGEN; PROLIFERATING CELL NUCLEAR ANTIGEN; TYMPANIC MEMBRANE;

EID: 79952201228     PISSN: 18088694     EISSN: 18088686     Source Type: Journal    
DOI: 10.1590/S1808-86942010000500023     Document Type: Article

References (16)

1. Vennix PP, Kuijpers W, Peters TA, Tonnaer ELGM, Ramaekers FCS. Epidermal differentiation in the human external auditory meatus. Laryngoscope. 1996;106(4):470-475.
2. Naim R, Sadick H, Schafer C, Hormann K. External auditory canal cholesteatoma: analysis of the integrity of the tissue structure. Int J Mol Med. 2004;14(4):601-604.
3. Ribeiro FAQ, Pereira CSB, Almeida R. Comparative study of histologi-cal and immunohistochemical aspects of spontaneous cholesteatomas of the external ear canal and acquired cholesteatoma of the middle ear. Rev Bras Otorrinolaringol. 2004;70(5):602-607.
4. Broekaert D, Boedts D. The proliferative capacity of the keratinizing annular epithelium. Acta Otolaryngol. 1993;113(3):345-348.
5. Lepercque S, Broekaert D, van Cauwenberge P. Cytokeratin expression patterns in the human tympanic membrane and external ear canal. Eur Arch Otorhinolaryngol. 1993;250(2):78-81.
6. Kim CS, Chung JW. Morphologic and biologic changes of experimentally induced cholesteatoma in Mongolian gerbils with anticytokeratin and lectin study. Am J Otol. 1999;20(1):13-18
7. Broekaert D, Coucke P, Lepercque S, Ramaekers F, Van Muijen G, Boedts D, et al. Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. Ann Otol Rhinol Laryngol. 1992;101(11):931-938.
8. Kakoi H, Anniko M, Kinnefors A, Rask-Andersen H. Auditory epidermal cell proliferation. VII. Antigen expression of proliferating cell nuclear antigens, PCNA and Ki-67 in human tympanic membrane and external auditory canal. Acta Otolaryngol. 1997;117(1):100-108.
9. Schilling V, Lang S, Rasp G, Mack B, Nerlich A. Overexpression of tenascin in cholesteatoma and external auditory meatal skin compared to retroauricular epidermis. Acta Otolaryngol. 1996;116(5):741-746.
10. Adamczyk M, Sudhoff H, Jahnke K. Immunohistochemical investigations on external auditory canal cholesteatomas. Otol Neurotol. 2003;24(5):705-708.
11. Raynov AM, Moon SK, Choung YH, Hong SP, Park K. Nucleoplasm staining patterns and cell cycle-associated expression of Ki-67 in middle ear cholesteatoma. Am J Otolaryngol. 2005;26(5):296-301.
12. Hwang SJ, Kang HJ, Song JJ, Kang JS, Woo JS, Chae SW, et al. Up-regulation of peroxidase proliferator-activated receptor gamma in cholesteatoma. Laryngoscope. 2006;116(1):58-61.
13. Kojima H, Tanaka Y, Tanaka T, Miyazaki H, Shiwa M, Kamide Y, et al. Cell proliferation and apoptosis in human middle ear cholesteatoma. Arch Otolaryngol Head Neck Surg. 1998;124(3):261-264.
14. Tanaka Y, Shiwa M, Kojima H, Miyazaki H, Kamide Y, Moriyama H. A study on epidermal proliferation ability in cholesteatoma. Laryngoscope. 1998;108(4 Pt 1):537-542.
15. Bayazít YA, Karakok M, Ucak R, Kanlikama M. Cycline-dependent kinase inhibitor, p27 (KIP1), is associated with cholesteatoma. Laryngoscope. 2001;111(6):1037-1041.
16. Sanjuan M, Sabatier F, Andrac-Meyer L, Lavieille JP, Magnan J. Ear canal keratinocyte culture: clinical perspective. Otol Neurotol. 2007;28(4):504-509.