Atomic force microscopy of biological samples

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volumn 2, Issue 6, 2010, Pages 618-634

  Allison, David P ^a,c   Mortensen, Ninell P ^a   Sullivan, Claretta J ^b   Doktycz, Mitchel J ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFM CANTILEVERS; ATOMIC FORCE MICROSCOPES; BIOLOGICAL RESEARCH; BIOLOGICAL SAMPLES; BIOLOGICAL SCIENCE; BIOLOGICAL SURFACES; CANTILEVER TIP; CONTACT-MODE AFM; FAST SCANNING; HIGH-RESOLUTION MICROSCOPY; KELVIN FORCE MICROSCOPY; NEW APPLICATIONS; NON-CONTACT; NON-CONTACT MODE; REAL TIME; RESEARCH TOOLS; SCANNING ELECTROCHEMICAL MICROSCOPES; SCANNING NEAR FIELD; SCANNING TUNNELING MICROSCOPES; STRUCTURAL-FUNCTIONAL RELATIONSHIP;

ATOMIC FORCE MICROSCOPY; MICROSCOPES; MOLECULAR BIOLOGY; NANOCANTILEVERS; RESEARCH; SCANNING; SCANNING TUNNELING MICROSCOPY; ULTRASONIC TESTING;

ANALYTIC EQUIPMENT;

ATOMIC FORCE MICROSCOPY; BIOASSAY; BIOLOGY; BIOMEDICINE; FLUORESCENCE MICROSCOPY; GENOMICS; HUMAN; IMAGING SYSTEM; ION CONDUCTANCE; KELVIN FORCE MICROSCOPY; MICROSCOPE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCANNING ELECTROCHEMICAL MICROSCOPY; SCANNING IONCONDUCTANCE MICROSCOPY; SCANNING NEAR FIELD ULTRASONIC HOLOGRAPHY; SCANNING PROBE MICROSCOPY; SCANNING TUNNELING MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BACTERIUM; CELL LINE; CHEMISTRY; INSTRUMENTATION; METHODOLOGY; VIRUS;

DNA; PROTEIN;

ANIMALS; BACTERIA; CELL LINE; DNA; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, SCANNING TUNNELING; PROTEINS; VIRUSES;

EID: 79952198205     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.104     Document Type: Review

References (159)

1. Binnig G, Rohrer H. Scanning tunneling microscopy. Helv Phys Acta 1982, 55: 726-735.
2. Lindsay SM, Thundat T, Nagahara L, Knipping U, Rill RL. Images of the DNA double helix in water. Science 1989, 244: 1063-1064.
3. Dunlap DD, Bustamante C. Images of single-stranded nucleic acids by scanning tunnelling microscopy. Nature 1989, 342: 204-206.
4. Amrein M, Stasiak A, Gross H, Stoll E, Travaglini G. Scanning tunneling microscopy of recA-DNA complexes coated with a conducting film. Science 1988, 240: 514-516.
5. Lindsay SM, Barris B. Imaging Deoxyribose Nucleic-Acid molecules on a metal-surface under water by scanning tunneling microscopy. J Vac Sci Technol A 1988, 6: 544-547.
6. Beebe TP, Wilson TE, Ogletree DF, Katz JE, Balhorn R, Salmeron MB, Siekhaus WJ. Direct observation of native DNA structures with the scanning tunneling microscope. Science 1989, 243: 370-372.
7. Allison DP, Bottomley LA, Thundat T, Brown GM, Woychik RP, Schrick JJ, Jacobson KB, Warmack RJ. Immobilization of DNA for scanning probe microscopy. Proc Natl Acad Sci U S A 1992, 89: 10129-10133.
8. Binnig G, Rohrer H. Scanning tunneling microscopy. In: Janta J, Pantoflicek J, eds. European Physical Society General Conference, 6th, Prague, Czechoslovakia, 1984.
9. Dahn DC, Watanabe MO, Blackford BL, Jericho MH, Beveridge TJ. Scanning tunneling microscopy imaging of biological structures. J Vac Sci Technol A 1988, 6: 548-552.
10. Hameroff S, Simickrstic Y, Vernetti L, Lee YC, Sarid D, Wiedmann J, Elings V, Kjoller K, McCuskey R. Scanning tunneling microscopy of cytoskeletal proteins-microtubules and intermediate filaments. J Vac Sci Technol A 1990, 8: 687-691.
11. Edstrom RD, Meinke MH, Yang X, Yang R, Elings V, Evans DF. Direct visualization of phosphorylase-phosphorylase kinase complexes by scanning tunneling and atomic force microscopy. Biophys J 1990, 58: 1437-1448.
12. Guckenberger R, Wiegrabe W, Hillebrand A, Hartmann T, Wang ZH, Baumeister W. Scanning tunneling microscopy of a hydrated bacterial surface protein. Ultramicroscopy 1989, 31: 327-332.
13. Welland ME, Miles MJ, Lambert N, Morris VJ, Coombs JH, Pethica JB. Structure of the globular protein vicilin revealed by scanning tunnelling microscopy. Int J Biol Macromol 1989, 11: 29-32.
14. Miles MJ, Carr HJ, McMaster TC, I'Anson KJ, Belton PS, Morris VJ, Field JM, Shewry PR, Tatham AS. Scanning tunneling microscopy of a wheat seed storage protein reveals details of an unusual supersecondary structure. Proc Natl Acad Sci U S A 1991, 88: 68-71.
15. Mantovani JG, Allison DP, Warmack RJ, Ferrell TL, Ford JR, Manos RE, Thompson JR, Reddick BB, Jacobson KB. Scanning tunneling microscopy of tobacco mosaic-virus on evaporated and sputter-coated palladium gold substrates. J Microsc 1990, 158: 109-116.
16. Baro AM, Miranda R, Alaman J, Garcia N, Binnig G, Rohrer H, Gerber C, Carrascosa JL. Determination of surface-topography of biological specimens at high-resolution by scanning tunnelling microscopy. Nature 1985, 315: 253-254.
17. Binnig G, Quate CF, Gerber C. Atomic force microscope. Phys Rev Lett 1986, 56: 930-933.
18. Thundat T, Allison DP, Warmack RJ, Ferrell TL. Imaging isolated strands of DNA-molecules by atomic force microscopy. Ultramicroscopy 1992, 42: 1101-1106.
19. Lindsay SM, Tao NJ, Derose JA, Oden PI, Lyubchenko YL, Harrington RE, Shlyakhtenko L. Potentiostatic deposition of DNA for scanning probe microscopy. Biophys J 1992, 61: 1570-1584.
20. Lyubchenko YL, Gall AA, Shlyakhtenko LS, Harrington RE, Jacobs BL, Oden PI, Lindsay SM. Atomic force microscopy imaging of double-stranded DNA and RNA. J Biomol Struct Dyn 1992, 10: 589-606.
21. Bustamante C, Vesenka J, Tang CL, Rees W, Guthold M, Keller R. Circular DNA-molecules imaged in air by scanning force microscopy. Biochemistry 1992, 31: 22-26.
22. Hansma PK, Cleveland JP, Radmacher M, Walters DA, Hillner PE, Bezanilla M, Fritz M, Vie D, Hansma HG, Prater CB, et al. Tapping mode atomic-force microscopy in liquids. Appl Phys Lett 1994, 64: 1738-1740.
23. Han WH, Lindsay SM, Jing TW. A magnetically driven oscillating probe microscope for operation in liquids. Appl Phys Lett 1996, 69: 4111-4113.
24. Lantz MA, Oshea SJ, Welland ME. Force microscopy imaging in liquids using Ac techniques. Appl Phys Lett 1994, 65: 409-411.
25. Lin Y, Wang J, Wan LJ, Fang XH. Study of fibrinogen adsorption on self-assembled monolayers on Au(111) by atomic force microscopy. Ultramicroscopy 2005, 105: 129-136.
26. Radmacher M, Fritz M, Cleveland JP, Walters DA, Hansma PK. Imaging adhesion forces and elasticity of lysozyme adsorbed on mica with the atomic-force microscope. Langmuir 1994, 10: 3809-3814.
27. Quist AP, Bjorck LP, Reimann CT, Oscarsson SO, Sundqvist BUR. A scanning force microscopy study of human serum-albumin and porcine pancreas trypsin adsorption on mica surfaces. Surf Sci 1995, 325: L406-L412.
28. Hallett P, Offer G, Miles MJ. Atomic-force microscopy of the myosin molecule. Biophys J 1995, 68: 1604-1606.
29. Hansma HG, Vesenka J, Siegerist C, Kelderman G, Morrett H, Sinsheimer RL, Elings V, Bustamante C, Hansma PK. Reproducible imaging and dissection of plasmid DNA under liquid with the atomic force microscope. Science 1992, 256: 1180-1184.
30. Henderson E, Haydon PG, Sakaguchi DS. Actin filament dynamics in living glial-cells imaged by atomic force microscopy. Science 1992, 257: 1944-1946.
31. Radmacher M, Tillmann RW, Fritz M, Gaub HE. From molecules to cells-imaging soft samples with the atomic force microscope. Science 1992, 257: 1900-1905.
32. Shroff H, Galbraith CG, Galbraith JA, Betzig E. Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics. Nat Methods 2008, 5: 417-423.
33. Gustafsson MG. Super-resolution light microscopy goes live. Nat Methods 2008, 5: 385-387.
34. Fernandez-Suarez M, Ting AY. Fluorescent probes for super-resolution imaging in living cells. Nat Rev Mol Cell Biol 2008, 9: 929-943.
35. Hell SW. Toward fluorescence nanoscopy. Nat Biotechnol 2003, 21: 1347-1355.
36. Panzer D, Beck C, Maul J, Moller M, Decker H, Schonhense G. Transmission photoemission electron microscopy for lateral mapping of the X-ray absorption structure of a metalloprotein in a liquid cell. Eur Biophys J 2008, 38: 53-58.
37. de Jonge N, Peckys DB, Kremers GJ, Piston DW. Electron microscopy of whole cells in liquid with nanometer resolution. Proc Natl Acad Sci U S A 2009, 106: 2159-2164.
38. Hansma HG, Kim KJ, Laney DE, Garcia RA, Argaman M, Allen MJ, Parsons SM. Properties of biomolecules measured from atomic force microscope images: a review. J Struct Biol 1997, 119: 99-108.
39. Bustamante C, Rivetti C. Visualizing protein-nucleic acid interactions on a large scale with the scanning force microscope. Annu Rev Biophys Biomol Struct 1996, 25: 395-429.
40. Morris VJ, Kirby AR, Gunning AP. Atomic Force Microscopy for Biologists. London: Imperial College Press; 1999.
41. Watanabe Y, Sakurai T. Advances in Scanning Probe Microscopy. New York: Springer-Verlag; 2000.
42. Bonnell D. Scanning Probe Microscopy and Spectroscopy: Theory, Techniques, and Applications. New York: John Wiley & Sons Inc.; 2000.
43. Muller DJ. AFM: a nanotool in membrane biology. Biochemistry 2008, 47: 7986-7998.
44. Muller DJ, Helenius J, Alsteens D, Dufrene YF. Force probing surfaces of living cells to molecular resolution. Nat Chem Biol 2009, 5: 383-390.
45. Puchner EM, Gaub HE. Force and function: probing proteins with AFM-based force spectroscopy. Curr Opin Struct Biol 2009, 19: 605-614.
46. Giocondi MC, Seantier B, Dosset P, Milhiet PE, Le Grimellec C. Characterizing the interactions between GPI-anchored alkaline phosphatases and membrane domains by AFM. Pflugers Arch 2008, 456: 179-188.
47. Parot P, Dufrene YF, Hinterdorfer P, Le Grimellec C, Navajas D, Pellequer JL, Scheuring S. Past, present and future of atomic force microscopy in life sciences and medicine. J Mol Recogn 2007, 20: 418-431.
48. Butt HJ, Wolff EK, Gould SAC, Northern BD, Peterson CM, Hansma PK. Imaging cells with the atomic force microscope. J Struct Biol 1990, 105: 54-61.
49. Haberle W, Horber JKH, Binnig G. Force microscopy on living cells. J Vac Sci Technol B 1991, 9: 1210-1213.
50. Haberle W, Horber JKH, Ohnesorge F, Smith DPE, Binnig G. Insitu investigations of single living cells infected by viruses. Ultramicroscopy 1992, 42: 1161-1167.
51. Horber JK, Haberle W, Ohnesorge F, Binnig G, Liebich HG, Czerny CP, Mahnel H, Mayr A. Investigation of living cells in the nanometer regime with the scanning force microscope. Scanning Microsc 1992, 6: 919-929. Discussion 929-930
52. Hoh JH, Schoenenberger CA. Surface-morphology and mechanical-properties of Mdck monolayers by atomic-force microscopy. J Cell Sci 1994, 107: 1105-1114.
53. Fritz M, Radmacher M, Gaub HE. Granula motion and membrane spreading during activation of human platelets imaged by atomic-force microscopy. Biophys J 1994, 66: 1328-1334.
54. Le Grimellec C, Lesniewska E, Cachia C, Schreiber JP, Defornel F, Goudonnet JP. Imaging of the membrane-surface of Mdck cells by atomic-force microscopy. Biophys J 1994, 67: 36-41.
55. Kasas S, Ikai A. A method for anchoring round shaped cells for atomic-force microscope imaging. Biophys J 1995, 68: 1678-1680.
56. Dufrene YF, Boonaert CJP, Gerin PA, Asther M, Rouxhet PG. Direct probing of the surface ultrastructure and molecular interactions of dormant and germinating spores of Phanerochaete chrysosporium. J Bacteriol 1999, 181: 5350-5354.
57. Touhami A, Jericho MH, Beveridge TJ. Atomic force microscopy of cell growth and division in Staphylococcus aureus. J Bacteriol 2004, 186: 3286-3295.
58. van der Mei HC, Busscher HJ, Bos R, de Vries J, Boonaert CJP, Dufrene YF. Direct probing by atomic force microscopy of the cell surface softness of a fibrillated and nonfibrillated oral streptococcal strain. Biophys J 2000, 78: 2668-2674.
59. Francius G, Domenech O, Mingeot-Leclercq MP, Dufrene YF. Direct observation of staphylococcus aureus cell wall digestion by lysostaphin. J Bacteriol 2008, 190: 7904-7909.
60. Mendez-Vilas A, Gallardo-Moreno AM, Gonzalez-Martin ML. Atomic force microscopy of mechanically trapped bacterial cells. Microsc Microanal 2007, 13: 55-64.
61. Beckmann MA, Venkataraman S, Doktycz MJ, Nataro JP, Sullivan CJ, Morrell-Falvey JL, Allison DP. Measuring cell surface elasticity on enteroaggregative Escherichia coli wild type and dispersin mutant by AFM. Ultramicroscopy 2006, 106: 695-702.
62. Mortensen NP, Fowlkes JD, Sullivan CJ, Allison DP, Larsen NB, Molin S, Doktycz MJ. Effects of colistin on surface ultrastructure and nanomechanics of Pseudomonas aeruginosa cells. Langmuir 2009, 25: 3728-3733.
63. Sullivan CJ, Venkataraman S, Retterer ST, Allison DP, Doktycz MJ. Comparison of the indentation and elasticity of E-coli and its spheroplasts by AFM. Ultramicroscopy 2007, 107: 934-942.
64. Shu AC, Wu CC, Chen YY, Peng HL, Chang HY, Yew TR. Evidence of DNA transfer through F-pilus channels during Escherichia coli conjugation. Langmuir 2008, 24: 6796-6802.
65. Arce FT, Carlson R, Monds J, Veeh R, Hu FZ, Stewart PS, Lal R, Ehrlich GD, Avci R. Nanoscale structural and mechanical properties of nontypeable haemophilus influenzae biofilms. J Bacteriol 2009, 191: 2512-2520.
66. Plomp M, Leighton TJ, Wheeler KE, Hill HD, Malkin AJ. In vitro high-resolution structural dynamics of single germinating bacterial spores. Proc Natl Acad Sci U S A 2007, 104: 9644-9649.
67. Doktycz MJ, Sullivan CJ, Hoyt PR, Pelletier DA, Wu S, Allison DP. AFM imaging of bacteria in liquid media immobilized on gelatin coated mica surfaces. Ultramicroscopy 2003, 97: 209-216.
68. Schoenenberger CA, Hoh JH. Slow cellular-dynamics in Mdck and R5 cells monitored by time-lapse atomic-force microscopy. Biophys J 1994, 67: 929-936.
69. Weisenhorn AL, Khosandi M, Kasas S, Gotzos V, Butt HJ. Deformation and height anomaly of soft surfaces studied with an AFM. Nanotechnology 1993, 4: 106-113.
70. Radmacher M, Fritz M, Hansma PK. Imaging soft samples with the atomic-force microscope-gelatin in water and propanol. Biophys J 1995, 69: 264-270.
71. Radmacher M. Measuring the elastic properties of biological samples with the AFM. IEEE Eng Med Biol Mag 1997, 16: 47-57.
72. Le Grimellec C, Lesniewska E, Giocondi MC, Finot E, Vie V, Goudonnet JP. Imaging of the surface of living cells by low-force contact-mode atomic force microscopy. Biophys J 1998, 75: 695-703.
73. Lesniewska E, Giocondi MC, Vie V, Finot E, Goudonnet JP, Le Grimellec C. Atomic force microscopy of renal cells: limits and prospects. Kidney Int 1998, 53((Supp 65)): S42-S48.
74. Parpura V, Haydon PG, Henderson E. 3-Dimensional imaging of living neurons and Glia with the atomic force microscope. J Cell Sci 1993, 104: 427-432.
75. You HX, Yu L. Atomic force microscopy imaging of living cells: progress, problems and prospects. Methods Cell Sci 1999, 21: 1-17.
76. Vie V, Giocondi MC, Lesniewska E, Finot E, Goudonnet JP, Le Grimellec C. Tapping-mode atomic force microscopy on intact cells: optimal adjustment of tapping conditions by using the deflection signal. Ultramicroscopy 2000, 82: 279-288.
77. Lucius H, Friedrichson T, Kurzchalia TV, Lewin GR. Identification of caveolae-like structures on the surface of intact cells using scanning force microscopy. J Membr Biol 2003, 194: 97-108.
78. Nagao E, Dvorak JA. An integrated approach to the study of living cells by atomic force microscopy. J Microsc 1998, 191: 8-19.
79. Le Grimellec C, Giocondi MC, Lenoir M, Vater M, Sposito G, Pujol R. High-resolution three-dimensional imaging of the lateral plasma membrane of cochlear outer hair cells by atomic force microscopy. J Comp Neurol 2002, 451: 62-69.
80. Hoh JH, Cleveland JP, Prater CB, Revel JP, Hansma PK. Quantized adhesion detected with the atomic force microscope. J Am Chem Soc 1992, 114: 4917-4918.
81. Goldmann WH, Galneder R, Ludwig M, Xu WM, Adamson ED, Wang N, Ezzell RM. Differences in elasticity of vinculin-deficient F9 cells measured by magnetometry and atomic force microscopy. Exp Cell Res 1998, 239: 235-242.
82. Yao X, Jericho M, Pink D, Beveridge T. Thickness and elasticity of gram-negative murein sacculi measured by atomic force microscopy. J Bacteriol 1999, 181: 6865-6875.
83. Yao X, Walter J, Burke S, Stewart S, Jericho MH, Pink D, Hunter R, Beveridge TJ. Atomic force microscopy and theoretical considerations of surface properties and turgor pressures of bacteria. Colloids Surf B Biointerfaces 2002, 23: 213-230.
84. Velegol SB, Logan BE. Contributions of bacterial surface polymers, electrostatics, and cell elasticity to the shape of AFM force curves. Langmuir 2002, 18: 5256-5262.
85. Arnoldi M, Fritz M, Bauerlein E, Radmacher M, Sackmann E, Boulbitch A. Bacterial turgor pressure can be measured by atomic force microscopy. Phys Rev E 2000, 62: 1034-1044.
86. Gaboriaud F, Bailet S, Dague E, Jorand F. Surface structure and nanomechanical properties of Shewanella putrefaciens bacteria at two pH values (4 and 10) determined by atomic force microscopy. J Bacteriol 2005, 187: 3864-3868.
87. Gaboriaud F, Dufrene YF. Atomic force microscopy of microbial cells: application to nanomechanical properties, surface forces and molecular recognition forces. Colloids Surf B Biointerfaces 2007, 54: 10-19.
88. Pelling AE, Li YN, Shi WY, Gimzewski JK. Nanoscale visualization and characterization of Myxococcus xanthus cells with atomic force microscopy. Proc Natl Acad Sci U S A 2005, 102: 6484-6489.
89. Cerf A, Cau JC, Vieu C, Dague E. Nanomechanical properties of dead or alive single-patterned bacteria. Langmuir 2009, 25: 5731-5736.
90. Charras GT, Horton MA. Single cell mechanotransduction and its modulation analyzed by atomic force microscope indentation. Biophys J 2002, 82: 2970-2981.
91. A-Hassan E, Heinz WF, Antonik MD, D'Costa NP, Nageswaran S, Schoenenberger CA, Hoh JH. Relative microelastic mapping of living cells by atomic force microscopy. Biophys J 1998, 74: 1564-1578.
92. Schmitz J, Benoit M, Gottschalk KE. The viscoelasticity of membrane tethers and its importance for cell adhesion. Biophys J 2008, 95: 1448-1459.
93. Matzke R, Jacobson K, Radmacher M. Direct, high-resolution measurement of furrow stiffening during division of adherent cells. Nat Cell Biol 2001, 3: 607-610.
94. Birukova AA, Arce FT, Moldobaeva N, Dudek SM, Garcia JG, Lal R, Birukov KG. Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: atomic force microscopy force mapping of pulmonary endothelial monolayer. Nanomedicine 2009, 5: 30-41.
95. Roduit C, van der Goot FG, De Los Rios P, Yersin A, Steiner P, Dietler G, Catsicas S, Lafont F, Kasas S. Elastic membrane heterogeneity of living cells revealed by stiff nanoscale membrane domains. Biophys J 2008, 94: 1521-1532.
96. Mathur AB, Collinsworth AM, Reichert WM, Kraus WE, Truskey GA. Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy. J Biomech 2001, 34: 1545-1553.
97. Takai E, Costa KD, Shaheen A, Hung CT, Guo XE. Osteoblast elastic modulus measured by atomic force microscopy is substrate dependent. Ann Biomed Eng 2005, 33: 963-971.
98. Boland T, Ratner BD. Direct measurement of hydrogen bonding in DNA nucleotide bases by atomic force microscopy. Proc Natl Acad Sci U S A 1995, 92: 5297-5301.
99. Lee GU, Chrisey LA, Colton RJ. Direct measurement of the forces between complementary strands of DNA. Science 1994, 266: 771-773.
100. Florin EL, Moy VT, Gaub HE. Adhesion forces between individual ligand-receptor pairs. Science 1994, 264: 415-417.
101. Moy VT, Florin EL, Gaub HE. Intermolecular forces and energies between ligands and receptors. Science 1994, 266: 257-259.
102. Lee GU, Kidwell DA, Colton RJ. Sensing discrete streptavidin biotin interactions with atomic-force microscopy. Langmuir 1994, 10: 354-357.
103. Benoit M, Gabriel D, Gerisch G, Gaub HE. Discrete interactions in cell adhesion measured by single-molecule force spectroscopy. Nat Cell Biol 2000, 2: 313-317.
104. Han T, Williams JM, Beebe TP. Chemical-bonds studied with functionalized atomic-force microscopy tips. Anal Chim Acta 1995, 307: 365-376.
105. Rief M, Gautel M, Oesterhelt F, Fernandez JM, Gaub HE. Reversible unfolding of individual titin immunoglobulin domains by AFM. Science 1997, 276: 1109-1112.
106. Marszalek PE, Lu H, Li H, Carrion-Vazquez M, Oberhauser AF, Schulten K, Fernandez JM. Mechanical unfolding intermediates in titin modules. Nature 1999, 402: 100-103.
107. Tskhovrebova L, Trinick J. Extensibility in the titin molecule and its relation to muscle elasticity. Adv Exp Med Biol 2000, 481: 163-173. discussion 174-178
108. Oberhauser AF, Marszalek PE, Erickson HP, Fernandez JM. The molecular elasticity of the extracellular matrix protein tenascin. Nature 1998, 393: 181-185.
109. Muller DJ, Baumeister W, Engel A. Controlled unzipping of a bacterial surface layer with atomic force microscopy. Proc Natl Acad Sci U S A 1999, 96: 13170-13174.
110. Li HB, Rief M, Oesterhelt F, Gaub HE, Zhang X, Shen JC. Single-molecule force spectroscopy on polysaccharides by AFM-nanomechanical fingerprint of alpha-(1, 4)-linked polysaccharides. Chem Phys Lett 1999, 305: 197-201.
111. Li HB, Zhang WK, Xu WQ, Zhang X. Hydrogen bonding governs the elastic properties of poly(vinyl alcohol) in water: Single-molecule force spectroscopic studies of PVA by AFM. Macromolecules 2000, 33: 465-469.
112. Wildling L, Hinterdorfer P, Kusche-Vihrog K, Treffner Y, Oberleithner H. Aldosterone receptor sites on plasma membrane of human vascular endothelium detected by a mechanical nanosensor. Pflugers Arch 2009, 458: 223-230.
113. Gad M, Itoh A, Ikai A. Mapping cell wall polysaccharides of living microbial cells using atomic force microscopy. Cell Biol Int 1997, 21: 697-706.
114. Grandbois M, Dettmann W, Benoit M, Gaub HE. Affinity imaging of red blood cells using an atomic force microscope. J Histochem Cytochem 2000, 48: 719-724.
115. Jiang YX, Wang J, Fang XH, Bai CL. Study of the effect of metal ion on the specific interaction between protein and aptamer by atomic force microscopy. J Nanosci Nanotechnol 2004, 4: 611-615.
116. Dupres V, Menozzi FD, Locht C, Clare BH, Abbott NL, Cuenot S, Bompard C, Raze D, Dufrene YF. Nanoscale mapping and functional analysis of individual adhesins on living bacteria. Nat Methods 2005, 2: 515-520.
117. Alsteens D, Dague E, Rouxhet PG, Baulard AR, Dufrene YF. Direct measurement of hydrophobic forces on cell surfaces using AFM. Langmuir 2007, 23: 11977-11979.
118. Touhami A, Hoffmann B, Vasella A, Denis FA, Dufrene YF. Aggregation of yeast cells: direct measurement of discrete lectin-carbohydrate interactions. Microbiology 2003, 149: 2873-2878.
119. Gilbert Y, Deghorain M, Wang L, Xu B, Pollheimer PD, Gruber HJ, Errington J, Hallet B, Haulot X, Verbelen C, et al. Single-molecule force spectroscopy and imaging of the vancomycin/D-Ala-D-Ala interaction. Nano Lett 2007, 7: 796-801.
120. Pfister G, Stroh CM, Perschinka H, Kind M, Knoflach M, Hinterdorfer P, Wick G. Detection of HSP60 on the membrane surface of stressed human endothelial cells by atomic force and confocal microscopy. J Cell Sci 2005, 118: 1587-1594.
121. Wojcikiewicz EP, Abdulreda MH, Zhang X, Moy VT. Force spectroscopy of LFA-1 and its ligands, ICAM-1 and ICAM-2. Biomacromolecules 2006, 7: 3188-3195.
122. Chtcheglova LA, Waschke J, Wildling L, Drenckhahn D, Hinterdorfer P. Nano-scale dynamic recognition imaging on vascular endothelial cells. Biophys J 2007, 93: L11-L13.
123. Almqvist N, Bhatia R, Primbs G, Desai N, Banerjee S, Lal R. Elasticity and adhesion force mapping reveals real-time clustering of growth factor receptors and associated changes in local cellular rheological properties. Biophys J 2004, 86: 1753-1762.
124. Lehenkari PP, Charras GT, Nykanen A, Horton MA. Adapting atomic force microscopy for cell biology. Ultramicroscopy 2000, 82: 289-295.
125. Raab A, Han WH, Badt D, Smith-Gill SJ, Lindsay SM, Schindler H, Hinterdorfer P. Antibody recognition imaging by force microscopy. Nat Biotechnol 1999, 17: 902-905.
126. Stroh CM, Ebner A, Geretschlager M, Freudenthaler G, Kienberger F, Kamruzzahan ASM, Smith-Gil SJ, Gruber HJ, Hinterdorfer P. Simultaneous topography and recognition Imaging using force microscopy. Biophys J 2004, 87: 1981-1990.
127. Hansma HG, Laney DE. DNA binding to mica correlates with cationic radius: assay by atomic force microscopy. Biophys J 1996, 70: 1933-1939.
128. Thomson NH, Fritz M, Radmacher M, Cleveland JP, Schmidt CF, Hansma PK. Protein tracking and detection of protein motion using atomic force microscopy. Biophys J 1996, 70: 2421-2431.
129. Kasas S, Thomson NH, Smith BL, Hansma HG, Zhu X, Guthold M, Bustamante C, Kool ET, Kashlev M, Hansma PK. Escherichia coli RNA polymerase activity observed using atomic force microscopy. Biochemistry 1997, 36: 461-468.
130. Radmacher M, Fritz M, Hansma HG, Hansma PK. Direct observation of enzyme-activity with the atomic-force microscope. Science 1994, 265: 1577-1579.
131. Wang H, Bash R, Yodh JG, Hager G, Lindsay SM, Lohr D. Using atomic force microscopy to study nucleosome remodeling on individual nucleosomal arrays in situ. Biophys J 2004, 87: 1964-1971.
132. Rotsch C, Radmacher M. Drug-induced changes of cytoskeletal structure and mechanics in fibroblasts: an atomic force microscopy study. Biophys J 2000, 78: 520-535.
133. Ohnesorge FM, Horber JKH, Haberle W, Czerny CP, Smith DPE, Binnig G. AFM review study on pox viruses and living cells. Biophys J 1997, 73: 2183-2194.
134. Schneider SW, Sritharan KC, Geibel JP, Oberleithner H, Jena BP. Surface dynamics in living acinar cells imaged by atomic force microscopy: Identification of plasma membrane structures involved in exocytosis. Proc Natl Acad Sci U S A 1997, 94: 316-321.
135. Ando T, Kodera N, Takai E, Maruyama D, Saito K, Toda A. A high-speed atomic force microscope for studying biological macromolecules. Proc Natl Acad Sci U S A 2001, 98: 12468-12472.
136. Hansma PK, Drake B, Marti O, Gould SAC, Prater CB. The scanning ion-conductance microscope. Science 1989, 243: 641-643.
137. Bard AJ, Fan FRF, Pierce DT, Unwin PR, Wipf DO, Zhou FM. Chemical imaging of surfaces with the scanning electrochemical microscope. Science 1991, 254: 68-74.
138. Nonnenmacher M, Oboyle MP, Wickramasinghe HK. Kelvin probe force microscopy. Appl Phys Lett 1991, 58: 2921-2923.
139. Shekhawat GS, Dravid VP. Nanoscale imaging of buried structures via scanning near-field ultrasound holography. Science 2005, 310: 89-92.
140. Casuso I, Kodera N, Le Grimellec C, Ando T, Scheuring S. Contact-mode high-resolution high-speed atomic force microscopy movies of the purple membrane. Biophys J 2009, 97: 1354-1361.
141. Picco LM, Dunton PG, Ulcinas A, Engledew DJ, Hoshi O, Ushiki T, Miles MJ. High-speed AFM of human chromosomes in liquid. Nanotechnology 2008, 19.
142. Fantner GE, Schitter G, Kindt JH, Ivanov T, Ivanova K, Patel R, Holten-Andersen N, Adams J, Thurner PJ, Rangelow IW, et al. Components for high speed atomic force microscopy. Ultramicroscopy 2006, 106: 881-887.
143. Humphris ADL, Miles MJ, Hobbs JK. A mechanical microscope: high-speed atomic force microscopy. Appl Phys Lett 2005, 86.
144. Proksch R, Lal R, Hansma PK, Morse D, Stucky G. Imaging the internal and external pore structure of membranes in fluid: tappingmode scanning ion conductance microscopy. Biophys J 1996, 71: 2155-2157.
145. Korchev YE, Bashford CL, Milovanovic M, Vodyanoy I, Lab MJ. Scanning ion conductance microscopy of living cells. Biophys J 1997, 73: 653-658.
146. Shevchuk AI, Frolenkov GI, Sanchez D, James PS, Freedman N, Lab MJ, Jones R, Klenerman D, Korchev YE. Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy. Angew Chem Int Ed Engl 2006, 45: 2212-2216.
147. Novak P, Li C, Shevchuk AI, Stepanyan R, Caldwell M, Hughes S, Smart TG, Gorelik J, Ostanin VP, Lab MJ, et al. Nanoscale live-cell imaging using hopping probe ion conductance microscopy. Nat Methods 2009, 6: 279-281.
148. Lee C, Kwak JY, Anson FC. Application of scanning electrochemical microscopy to generation/collection experiments with high collection efficiency. Anal Chem 1991, 63: 1501-1504.
149. Kwak J, Bard AJ. Scanning electrochemical microscopy-theory of the feedback mode. Anal Chem 1989, 61: 1221-1227.
150. Wiedemair J, Balu B, Moon JS, Hess DW, Mizaikoff B, Kranz C. Plasma-deposited fluorocarbon films: insulation material for microelectrodes and combined atomic force microscopy-scanning electrochemical microscopy probes. Anal Chem 2008, 80: 5260-5265.
151. Kranz C, Friedbacher G, Mizaikoff B., Lugstein A, Smoliner J, Bertagnolli E. Integrating an ultramicroelectrode in an AFM cantilever: combined technology for enhanced information. Anal Chem 2001, 73: 2491-2500.
152. Kranz C, Kueng A, Lugstein A, Bertagnolli E, Mizaikoff B. Mapping of enzyme activity by detection of enzymatic products during AFM imaging with integrated SECM-AFM probes. Ultramicroscopy 2004, 100: 127-134.
153. Kueng A, Kranz C, Mizaikoff B, Lugstein A, Bertagnolli E, Mizaikoff B. AFM-tip integrated amperomtric biosensors: high resolution imaging of membrane transport. Angew Chem Int Ed 2005, 44: 3419-3422.
154. Kwak KJ, Yoda S, Fujihira M. Observation of stretched single DNA molecules by Kelvin probe force microscopy. Appl Surf Sci 2003, 210: 73-78.
155. Hane F, Moores B, Amrein M, Leonenko Z. Effect of SP-C on surface potential distribution in pulmonary surfactant: atomic force microscopy and Kelvin probe force microscopy study. Ultramicroscopy 2009, 109: 968-973.
156. Leonenko Z, Gill S, Baoukina S, Monticelli L, Doehner J, Gunasekara L, Felderer F, Rodenstein M, Eng LM, Amrein M. An elevated level of cholesterol impairs self-assembly of pulmonary surfactant into a functional film. Biophys J 2007, 93: 674-683.
157. Leonenko Z, Rodenstein M, Dohner J, Eng LM, Amrein M. Electrical surface potential of pulmonary surfactant. Langmuir 2006, 22: 10135-10139.
158. Leung C, Kinns H, Hoogenboom BW, Howorka S, Mesquida P. Imaging surface charges of individual biomolecules. Nano Lett 2009, 9: 2769-2773.
159. Tetard L, Passian A, Venmar KT, Lynch RM, Voy BH, Shekhawat G, Dravid VP, Thundat T. Imaging nanoparticles in cells by nanomechanical holography. Nat Nanotechnol 2008, 3: 501-505.