Malassezia virulence determinants

Current Opinion in Infectious Diseases

Volumn 24, Issue 2, 2011, Pages 100-105

  Hort, Wiebke ^a   Mayser, Peter ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

lipid metabolism; Malassezia; pigments; pityriasis versicolor; virulence

Indexed keywords

AZELAIC ACID; CYCLOSERINE; INDIRUBIN; INDOLE DERIVATIVE; LIPOXYGENASE; MELANIN; REACTIVE OXYGEN METABOLITE; VIRULENCE FACTOR;

ARTICLE; CONFLUENT AND RETICULATED PAPILLOMATOSIS; ENZYME ACTIVITY; FUNGAL VIRULENCE; FUNGUS HYPHAE; HUMAN; LIPID METABOLISM; LIPOLYSIS; MALASSEZIA; NONHUMAN; PATHOGENESIS; PSORIASIS; SEBORRHEIC DERMATITIS; TINEA VERSICOLOR;

DERMATITIS, SEBORRHEIC; DERMATOMYCOSES; HUMANS; MALASSEZIA; TINEA VERSICOLOR; VIRULENCE;

EID: 79952196541     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0b013e328342f787     Document Type: Article

References (77)

1. Baillon H. Traité de botanique mé dicale cryptogamique. Octave Doin, Paris 1889: 234-235.
2. Weidmann FD. Exfoliative dermatitis in the Indian rhinoceros (Rhinoceros unicornis), with description of a new species: Pityrosporum pachydermatis. In: Fox, H., editor. Rep Lab Museum Comp Pathol Zoo Soc Philadelphia, Philadelphia; 1925. pp. 36-43.
3. Simmons RB, Guého E. A new species of Malassezia. Mycol Res 1990; 94:1146-1149.
4. Guého E, Midgley G, Guillot J. The genus Malassezia with description of four new species. Antonie van Leeuwenhoek 1996; 69:337-355.
5. Sugita T, Takashima M, Shinoda T, et al. New yeast species, Malassezia dermatis, isolated from patients with atopic dermatitis. J Clin Microbiol 2002; 40:1363-1367. (Pubitemid 34279901)
6. Sugita T, Takashima M, Kodama M, et al. Description of a new yeast species, Malassezia japonica, and its detection in patients with atopic dermatitis and healthy subjects. J Clin Microbiol 2003; 41:4695-4699. (Pubitemid 37259779)
7. Hirai A, Kano R, Makimura K, et al. Malassezia nana sp. nov., a novel lipiddependent yeast species isolated from animals. Int J Syst Evol Microbiol 2004; 54 (Pt 2):623-627. (Pubitemid 38443768)
8. Sugita T, Tajima M, Takashima M, et al. A new yeast, Malassezia yamatoensis, isolated from a patient with seborrheic dermatitis, and its distribution in patients and healthy subjects. Microbiol Immunol 2004; 48:579-583. (Pubitemid 39100116)
9. Cabañes FJ, Theelen B, Castellá G, Boekhout T. Two new lipid-dependent Malassezia species from domestic animals. FEMS Yeast Res 2007; 7:1064-1076. (Pubitemid 47256348)
10. Cabañes FJ, Vega S, Castellá G. Malassezia cuniculi sp. nov., a novel yeast species isolated from rabbit skin. Med Mycol 2010 [Epub ahead of print].
11. Gupta AK, Batra R, Bluhm R, et al. Pityriasis versicolor. Dermatol Clin 2003; 21:413-442.
12. Porro MN, Passi S, Caprill F, et al.Growth requirement and lipid metabolism of Pityrosporum orbiculare. J Invest Dermatol 1976; 66:178-182.
13. Shifrine M, Marr AG. The requirement of fatty acids by Pityrosporum ovale. J Gen Microbiol 1963; 32:263-270.
14. Wilde PF, Stewart PS. A study of the fatty acid metabolism of the yeast Pityrosporum ovale. Biochem J 1968; 108:225-231.
15. Xu J, Saunders CW, Hu P, et al. Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Proc Natl Acad Sci U S A 2007; 104:18730-18735. (Pubitemid 350210765)
16. Huang HP, Little CJ, Fixter LM. Effects of fatty acids on the growth and composition of Malassezia pachydermatis and their relevance to canine otitis externa. Res Vet Sci 1993; 55:119-123.
17. Thompson E, Colvin JR. Composition of the cell wall of Pityrosporum ovale (Bizzozero) Castellani and Chalmers. Can J Microbiol 1970; 16:263-265.
18. Brotherton J. Lack of swelling and shrinking of Pityrosporum ovale in media of different osmotic pressures and its relationship with survival in the relatively dry condition of the scalp. J Gen Microbiol 1967; 48:305-308.
19. Kesavan S, Holland KT, Ingham E. The effects of lipid extraction on the immunomodulatory activity of Malassezia species in vitro. Med Mycol 2000; 38:239-247. (Pubitemid 30391937)
20. Kesavan S, Walters CE, Holland KT, et al. The effects of Malassezia on proinflammatory cytokine production by human peripheral blood mononuclear cells in vitro. Med Mycol 1998; 36:97-106.
21. Thomas DS, Ingham E, Bojar RA, Holland KT. In vitro modulation of human keratinocyte pro-and anti-inflammatory cytokine production by the capsule of Malassezia species. FEMS Immunol Med Microbiol 2008; 54:203-214.
22. Caprilli F, Mercantini R, Nazzaro-Porro M, et al. Studies of the genus Pityrosporum in submerged culture. Mycopathol Mycol Appl 1973; 51:171-189.
23. Weary PE. Comedogenic potential of the lipid extract of Pityrosporum ovale. Arch Dermatol 1970; 102:84-91.
24. Mayser P, Führer D, Schmidt R, et al. Hydrolysis of fatty acid esters by Malassezia furfur: different utilization depending on alcohol moiety. Acta Dermatol Venereol 1995; 75:105-109.
25. Mayser P, Haze P, Papavassilis C, et al. Differentiation of Malassezia spp. selectivity of cremophor EL, castor oil and ricinoleic acid for Malassezia furfur. Br J Dermatol 1997; 137:208-213. (Pubitemid 27333353)
26. Brunke S, Hube B. MfLIP1, a gene encoding an extracellular lipase of the lipiddependent fungus Malassezia furfur. Microbiology 2006; 152:547-554. (Pubitemid 43210685)
27. Shibate N, Okanuma N, Hirai K, et al. Isolation, characterization and molecular cloning of a lipolytic enzyme secreted from Malassezia pachydermatitis. FEMS Microbiol Lett 2006; 256:137-144.
28. DeAngelis YM, SaundersCW, Johnstone KR, et al. Isolation and expression of a Malassezia globosa lipase gene, LIP1. J Invest Dermatol 2007; 127:2138-2146. (Pubitemid 47258487)
29. Ro BI, Dawson TL. The role of sebaceous gland activity and scalp microfloral metabolism in the etiology of seborrheic dermatitis and dandruff. J Investig Dermatol Symp Proc 2005; 10:194-197.
30. Juntachai W, Oura T, Murayana SY, Kajiwara S. The lipolytic enzymes activities of Malassezia species. Med Mycol 2009; 47:477-484.
31. Cafarchia C, Otranto D. Association between phospholipase production by M. pachydermatitis and skin lesions. J Clin Microbiol 2004; 42:4868-4869. (Pubitemid 39362428)
32. Cafarchia C, Gasser RB, Latrofa MS, et al. Genetic variants of Malassezia pachydermatis from canine skin: body distribution and phospholipase activity. FEMS Yeast Res 2008; 8:451-459. (Pubitemid 351579658)
33. Riciputo RM, Oliveri S, Micali G, et al. Phospholipase activity in Malassezia furfur pathogenetic strains. Mycoses 1996; 39:233-235. (Pubitemid 26319932)
34. Calderone RA, Fonzi WA. Virulence factors in Candida albicans. Trends Microbiol 2001; 9:327-335.
35. Naglik JR, Challacombe SJ, Hube B. Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev 2003; 67:400-428. (Pubitemid 37122527)
36. Später S, Hipler UC, Haustein UF, Nenoff P. Formation of reactive oxygen species in vitro by Malassezia yeasts [in German]. Hautarzt 2009; 60:122-127.
37. Nazzaro-Porro M, Passi S, Picardo M, et al. Lipoxygenase activity of Pityrosporum in vitro and vivo. J Invest Dermatol 1986; 87:108-112. (Pubitemid 16090887)
38. De Luca C, Picardo M, Breathnach A, et al. Lipoperoxidase activity of Pityrosporum: characterisation of by-products and possible role in pityriasis versicolor. Exp Dermatol 1996; 5:49-56. (Pubitemid 26040621)
39. Nazzaro-Porro M, Passi S. Identification of tyrosinase inhibitors in cultures of Pityrosporum. J Invest Dermatol 1978; 71:205-208. (Pubitemid 9082184)
40. Breathnach AS, Nazzaro-Porro M, Passi S. Azelaic acid. Br J Dermatol 1984; 111:115-120. (Pubitemid 14086236)
41. Robins EJ, Breathnach AS, Bennet D, et al. Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and human melanoma cell line in tissue culture. Br J Dermatol 1985; 113:687-697. (Pubitemid 16186881)
42. Eichstedt CF. Fungus in pityriasis versicolor. Froriep's New Notes from the areas of science and medicine [in German]. 1846; 853:270-271.
43. Dorn M, Roehnert K. Dimorphism of Pityrosporum orbiculare in a defined culture medium. J Invest Dermatol 1977; 69:224-248.
44. Porro M, Passi S, Caprilli F, et al. Induction of hyphae in cultures of Pityrosporum by cholesterol and cholesterol esters. J Invest Dermatol 1977; 69:531-534. (Pubitemid 8239556)
45. Faergemann J, Bernander S. Micro-aerophilic and anaerobic growth of Pityrosporum orbiculare. Sabouraudia 1981; 17:171-179.
46. Saadatzadeh MR, Ashbee HR, Cunliffe WJ, et al. Cell-mediated immunity to the mycelial phase of Malassezia spp. in patients with pityriasis versicolor and controls. Br J Dermatol 2001; 144:77-84. (Pubitemid 32154596)
47. Crespo Erchiga V, Ojeda Mertos A, Vra Casano A, et al. Malassezia globosa as the causative agent of pityriasis versicolor. Br J Dermatol 2000; 143:799-803.
48. Burke RC. Tinea versicolor: susceptibility factors and experimental infections in human beings. J Invest Dermatol 1961; 36:389-401.
49. Gordon MA. The lipophilic mycoflora of the skin. I. In vitro culture of Pityrosporum orbiculare n.sp. Mycologia 1951; 43:524-535.
50. Guého E, Midgley G, Guillot J. The genus of Malassezia with description of four new species. Antonie van Leeuwenhoek 1996; 69:337-355.
51. Guého E, Boekhout T, Ashbee HR, et al. The role of Malassezia species in the ecology of human skin and as pathogens. Med Mycol 1998; 36:220-229.
52. Roberts SOB. Pityriasis versicolor: a clinical and mycological investigation. Br J Dermatol 1969; 81:315-326.
53. Slooff WC. Genus 6 Pityrosporum Sabouraud. In: Lodder J, editor. The yeasts, a taxonomic study, 2nd ed. Amsterdam: North-Holland Publishing Co; 1970. pp. 1167-1186.
54. McGinley KJ, Leyden LJ, Marples RR, et al. Quantitative microbiology of the scalp in nondandruff, dandruff and seborrheic dermatitis. J Invest Dermatol 1975; 64:401-405.
55. Langfelder K, Streibel M, Jahn B, et al. Biosynthesis of fungal melanins and their importance for human pathogenic fungi. Fungal Genet Biol 2003; 38:143-158. (Pubitemid 36279657)
56. Gaitanis G, Chasapi V, Velegraki A. Novel application of the masson-fontana stain for demonstrating Malassezia species melanin-like pigment production in vitro and in clinical specimens. J Clin Microbiol 2005; 43:4147-4151.
57. Mayser P, Imkampe A, Winkeler M, et al. Growth requirements and nitrogen metabolism of Malassezia furfur. Arch Dermatol Res 1998; 290:277-282. (Pubitemid 28301555)
58. Hossain HM, Landgraf V, Weiß R, et al. The genetic and biochemical characterization of the species Malassezia pachydermatis with particular attention on pigment-producing subgroups. Med Mycol 2007; 45:41-49. (Pubitemid 46992917)
59. Mayser P, Töws A, Krämer HJ, et al. Further characterization of pigmentproducing Malassezia strains. Mycoses 2004; 47:34-39. (Pubitemid 38375596)
60. Mayser P, Wille G, Imkampe A, et al. Synthesis of fluorochromes and pigments in Malassezia furfur by use of tryptophan as single nitrogen source. Mycoses 1998; 41:265-271. (Pubitemid 28553044)
61. Mayser P, Stapelkamp H, Krämer HJ, et al. Pityrialacton: a new fluorochrome from the tryptophan metabolism of Malassezia furfur. Antonie van Leeuwenhoek 2003; 84:185-191. (Pubitemid 37406807)
62. Dahms K, Krämer HJ, Thoma W, et al. Tyrosinase inhibition by tryptophan metabolites of Malassezia furfur in human epidermis [in German]. Mycoses 2002; 45:230.
63. Thoma W, Dahms K, Krämer HJ, et al. Tyrosinase inhibition by-KO27: a metabolic metabolite of Malassezia furfur [in German]. Mycoses 2001; 44:238.
64. Krämer HJ, Podobinska M, Bartsch A, et al. Malassezin, a novel agonist of the aryl hydrocarbon receptor from the yeast Malassezia furfur, induces apoptosis in primary human melanocytes. ChemBioChem 2005; 6:860-865. (Pubitemid 40873747)
65. Wille G, Mayser P, Thoma W, et al. Malassezin: a novel agonist of the aryl hydrocarbon receptor from the yeast Malassezia furfur. Bioorg Med Chem 2001; 9:955-960. (Pubitemid 32448116)
66. Krämer HJ, Kessler D, Hipler UC, et al. Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur: comparison with the bisindolylmaleimide arcyriarubin A. ChemBioChem 2005; 6:2290-2297.
67. Wroblewski N, Bär S, Mayser P. Missing granulocytic infiltrate in pityriasis versicolor: indication of specific anti-inflammatory activity of the pathogen? Mycoses 2005; 48 (Suppl 1):66-71.
68. Larangeira de Almeida H Jr, Mayser P. Absence of sunburn in lesions of pityriasis versicolor alba. Mycoses 2006; 49:516. (Pubitemid 44511105)
69. Thoma W, Krämer HJ, Mayser P. Pityriasis versicolor alba. JEADV 2005; 19:147-152. (Pubitemid 40450414)
70. Hort W, Lang S, Brunke S, Hube B, et al. Analysis of differentially expressed genes associated with tryptophan-dependent pigment synthesis in M. furfur by cDNA subtraction technology. Med Mycol 2009; 47:248-258.
71. Zuther K, Mayser P, Hettwer U, Wu W, et al. The tryptophan aminotransferase Tam1 catalyses the single biosynthetic step for tryptophan-dependent pigment synthesis in Ustilago maydis. Mol Microbiol 2008; 68:152-172. (Pubitemid 351363786)
72. Lang SK, Hort W, Mayser P. Differentially expressed genes associated with tryptophan-dependent pigment synthesis in Malassezia furfur: a comparison with the recently published genome of Malassezia globosa. Mycoses 2010 [Epub ahead of print].
73. Möhle H, Hort W, Mayser P. Analysis of gene expression of Mg-tam in lesions of pityriasis versicolor. Mycoses 2010; 53:404.
74. Mayser P, Rieche I. Rapid reversal of hyperpigmentation in pityriasis versicolor upon short-term topical cycloserine application. Mycoses 2009; 52:541-543; Epub 2009 Sep 22.
75. Fritsche E, Schäfer C, Calles C, et al. Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci U S A 2007; 104:8851-8856. (Pubitemid 47175400)
76. Gaitanis G, Magiatis P, Stathopoulou K, et al. AhR Ligands, malassezin, and indolo[3,2-b]carbazole are selectively produced by Malassezia furfur strains isolated from seborrheic dermatitis. J Invest Dermatol 2008; 128:1620-1625. (Pubitemid 351847379)
77. Giakoumaki D, Stathopoulou K, Melliou E, et al. Identification of indirubin as a metabolite of Malassezia furfur strains isolated from diseased skin [abstract]. In: 7th Joint Meeting of AFERP, ASP, GA, PSE, SIF on Natural Products: With Pharmaceutical, Neutraceutical, Cosmetic and Agrochemical Interest; Athenaum Intercontinental; 3-8 August 2008; Athens, Greece.