Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 5, 2011, Pages 1816-1822

  Nakagawa Goto, Kyoko ^a   Wu, Pei Chi ^a   Bastow, Kenneth F ^a   Yang, Shuenn Chen ^b   Yu, Sung Liang ^c   Chen, Hsuan Yu ^d   Lin, Jau Chen ^e   Goto, Masuo ^f   Morris Natschke, Susan L ^a   Yang, Pan Chyr ^b,c   Lee, Kuo Hsiung ^a,g  

^a University of North Carolina   (United States)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d INSTITUTE OF STATISTICAL SCIENCE   (Taiwan)

^e FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antiproliferative activity; Desmosdumotin C; Human tumor cell lines; Microarray

Indexed keywords

3,3,5 TRIPROPYL 5 PRENYLDESMOSDUMOTIN C; 4 ISOBUTOXY 3,3,5 TRIPROPYLDESMOSDUMOTIN C; 4 PROPOXY 3,3,5 TRIPROPYLDESMOSDUMOTIN C; ANTINEOPLASTIC AGENT; CARBON; DESMOSDUMOTIN C DERIVATIVE; METHYL GROUP; NATURAL PRODUCT; PACLITAXEL; PROPANE; UNCLASSIFIED DRUG; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CHROMOSOME; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS SPINDLE; STRUCTURE ACTIVITY RELATION;

ALKENES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KETONES; MITOTIC SPINDLE APPARATUS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NEOPLASMS;

EID: 79952192452     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.001     Document Type: Article

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