A prospective study of temozolomide plus thalidomide during and after radiation therapy for pediatric diffuse pontine gliomas: Preliminary results of the Korean Society for Pediatric Neuro-Oncology study

Journal of Neuro-Oncology

Volumn 100, Issue 2, 2010, Pages 193-198

  Kim, Chae Yong ^a,d   Kim, Seung Ki ^b,d   Phi, Ji Hoon ^b,d   Lee, Min Mi ^a,d   Kim, In Ah ^a,d   Kim, Il Han ^c,d   Wang, Kyu Chang ^b,d   Jung, Hye Lim ^e   Lee, Mee Jeong ^f   Cho, Byung Kyu ^b,d  

^a Seoul National University Bundang Hospital   (South Korea)

^b Seoul National University Children's Hospital   (South Korea)

^c Seoul National University Hospital   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e School of Medicine   (South Korea)

^f Dankook University College of Medicine   (South Korea)

Author keywords

Brainstem tumor; Concomitant chemoradiotherapy; Pontine tumor; Temozolomide; Thalidomide

Indexed keywords

TEMOZOLOMIDE; THALIDOMIDE;

ADOLESCENT; AGE DISTRIBUTION; ARTICLE; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHILD; CHILD CARE; CHILDHOOD CANCER; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG ERUPTION; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; GLIOMA; HUMAN; LEUKOPENIA; MALE; MAXIMUM TOLERATED DOSE; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; OVERALL SURVIVAL; PONTINE TUMOR; PRESCHOOL CHILD; PROGRESSION FREE SURVIVAL; SCHOOL CHILD; SEDATION; SIDE EFFECT; SURVIVAL TIME; THROMBOCYTOPENIA; TUMOR BIOPSY;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN STEM NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; DACARBAZINE; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; KOREA; MALE; PONS; PONTINE GLIOMA; THALIDOMIDE;

EID: 79952188499     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0157-1     Document Type: Article

References (34)

1. Broniscer A, Laningham FH, Sanders RP et al (2008) Young age may predict a better outcome for children with diffuse pontine glioma. Cancer 113:566-572
2. Bouffet E, Raquin M, Doz F et al (2000) Radiotherapy followed by high dose busulfan and thiotepa: a prospective assessment of high dose chemotherapy in children with diffuse pontine gliomas. Cancer 88:685-692 (Pubitemid 30056946)
3. Dunkel IJ, Garvin JH Jr, Goldman S (1998) High dose chemotherapy with autologous bone marrow rescue for children with diffuse pontine brain stem tumors. Children's Cancer Group. J Neurooncol 37:67-73 (Pubitemid 28073577)
4. Finlay JL, Zacharoulis S (2005) The treatment of high grade gliomas and diffuse intrinsic pontine tumors of childhood and adolescence: a historic - and futuristic - perspective. J Neurooncol 75:253-266 (Pubitemid 43023756)
5. Frazier JL, Lee J, Thomale UW et al (2009) Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies. J Neurosurg Pediatr 4:259-269
6. Grill J, Bhangoo R (2007) Recent development in chemotherapy of paediatric brain tumours. Curr Opin Oncol 19:612-615 (Pubitemid 47508870)
7. Jennings MT, Sposto R, Boyett JM et al (2002) Preradiation chemotherapy in primary high-risk brainstem tumors: phase II study CCG-9941 of the Children's Cancer Group. J Clin Oncol 20:3431-3437
8. Korones DN, Fisher PG, Kretschmar C et al (2008) Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: a Children's Oncology Group phase II study. Pediatr Blood Cancer 50(2):227-230
9. Kretschmar CS, Tarbell NJ, Barnes PD et al (1993) Pre-irradiation chemotherapy and hyperfractionated radiation therapy 66 Gy for children with brain stem tumors. A phase II study of the Pediatric Oncology Group, Protocol 8833. Cancer 72:1404-1413
10. Hargrave D, Chuang N, Bouffet E (2008) Conventional MRI cannot predict survival in childhood diffuse intrinsic pontine glioma. J Neurooncol 86:313-319
11. Leach PA, Estlin EJ, Coope DJ et al (2008) Diffuse brainstem gliomas in children: should we or shouldn't we biopsy? Br J Neurosurg 22:619-624
12. Massimino M, Spreafico F, Biassoni V et al (2008) Diffuse pontine gliomas in children: changing strategies, changing results? A mono-institutional 20-year experience. J Neurooncol 87:355-361
13. Qaddoumi I, Ezam N, Swaidan M et al (2009) Diffuse pontine glioma in Jordan and impact of up-front prognosis disclosure with parents and families. J Child Neurol 24:460-465
14. Rutka JT, Kuo JS, Carter M et al (2004) Advances in the treatment of pediatric brain tumors. Expert Rev Neurother 4:879-893 (Pubitemid 39186692)
15. Roujeau T, Machado G, Garnett MR et al (2007) Stereotactic biopsy of diffuse pontine lesions in children. J Neurosurg 107(1):1-4
16. Janssens GO, Gidding CE, Van Lindert EJ et al (2009) The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study. Int J Radiat Oncol Biol Phys 73:722-726
17. Marcus KJ, Dutton SC, Barnes P et al (2003) A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma. Int J Radiat Oncol Biol Phys 55:1182-1185 (Pubitemid 36338282)
18. Postovsky S, Eran A, Weyl Ben Arush M (2008) Unusual case of leptomeningeal dissemination of a diffuse pontine high-grade astrocytoma in a child. Pediatr Neurosurg 44:208-211 (Pubitemid 351555872)
19. Sirachainan N, Pakakasama S, Visudithbhan A et al (2008) Concurrent radiotherapy with temozolomide followed by adjuvant temozolomide and cis-retinoic acid in children with diffuse intrinsic pontine glioma. Neuro Oncol 10:577-582
20. Turner CD, Chi S, Marcus KJ et al (2007) Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme. J Neurooncol 82:95-101
21. Turner CD, Gururangan S, Eastwood J et al (2002) Phase II study of irinotecan (CPT-11) in children with high-risk malignant brain tumors: the Duke experience. Neuro Oncol 4:102-108 (Pubitemid 34285064)
22. Wolff JE, Westphal S, Mölenkamp G et al (2002) Treatment of paediatric pontine glioma with oral trophosphamide and etoposide. Br J Cancer 87:945-949 (Pubitemid 35305642)
23. Stupp R, Dietrich PY, Ostermann Kraljevic S et al (2002) Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 20:1375-1382 (Pubitemid 34177445)
24. Stupp R, Mason WP, van den Bent MJ et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987-996 (Pubitemid 40349501)
25. Perry J, Laperriere N, Zuraw L et al (2007) Adjuvant chemotherapy for adults with malignant glioma: a systematic review. Can J Neurol Sci 34:402-410 (Pubitemid 350248266)
26. Choi JW, Lee MM, Kim IA et al (2008) The outcomes of concomitant chemoradiotherapy followed by adjuvant chemotherapy with temozolomide for newly diagnosed high grade gliomas: the preliminary results of single center prospective study. J Korean Neurosurg Soc 44:222-227
27. Kocher M, Kunze S, Elch HT et al (2005) Efficacy and toxicity of postoperative temozolomide radiochemotherapy in malignant glioma. Strahlenther Onkol 18:157-163
28. Atkins MB, Sosman JA, Agarwala S et al (2008) Temozolomide, thalidomide, and whole brain radiation therapy for patients with brain metastasis from metastatic melanoma: a phase II Cytokine Working Group study. Cancer 113:2139-2145
29. Chang SM, Lamborn KR, Malec M et al (2004) Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnoses glioblastoma multiforme. Int J Radiat Oncol Biol Phys 60:353-357 (Pubitemid 39233451)
30. Kesari S, Schiff D, Henson JW et al (2008) Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol 10:300-308
31. Broniscer A, Iacono L, Chintagumpala M et al (2005) Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98). Cancer 103:133-139 (Pubitemid 39665466)
32. Puduvalli VK, Giglio P, Groves MD et al (2008) Phase II trial of irinotecan and thalidomide in adults with recurrent glioblastoma multiforme. Neuro Oncol 10:216-222
33. Knisely JP, Berkey B, Chakravarti A et al (2008) A phase III study of conventional radiation therapy plus thalidomide versus conventional radiation therapy for multiple brain metastases (RTOG 0118). Int J Radiat Oncol Biol Phys 71:79-86
34. Wagner S, Warmuth-Metz M, Emser A et al (2006) Treatment options in childhood pontine gliomas. J Neurooncol 79:281-287 (Pubitemid 44363731)