Micro-particle deposition and lobar distribution of mass flow in human upper respiratory tract model

Chinese Science Bulletin

Volumn 56, Issue 4-5, 2011, Pages 380-385

  Huang, JianHua ^a   Zhang, LianZhong ^a,b  

^a NANKAI UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

Author keywords

Asymmetric tracheobronchial airways; Computational fluid dynamics simulation; Lobar differences; Transportation and deposition; Upper respiratory tract

Indexed keywords

EID: 79952171337     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-010-4305-y     Document Type: Article

References (20)

1. Cheng Y S, Zhou Y, Chen B T. Particle deposition in a cast of human oral airways. Aerosol Sci Tech, 1999, 31: 286-300.
2. Zhang Z, Kleinstreuer C, Kim C S. Micro-particle transport and deposition in a human oral airway model. J Aerosol Sci, 2002, 33: 1635-1652.
3. Grgic B, Finlay W H, Heenan A F. Regional aerosol deposition and flow measurements in an idealized mouth and throat. J Aerosol Sci, 2004, 35: 21-32.
4. Johstone A, Uddin M, Pollard A, et al. The flow inside an idealised form of the human extra-thoracic airway. Expt Fluids, 2004, 37: 673-689.
5. Cai F S, Yu C P. Inertial and interceptional deposition of spherical particles and fibers in a bifurcating airway. J Aerosol Sci, 1988, 19: 679-688.
6. Cohen B S, Susman R G, Lippmann M. Ultrafine particle deposition in a human tracheobronchial cast. Aerosol Sci Tech, 1990, 12: 1082-1091.
7. Zhou Y, Cheng Y S. Particle deposition in a cast of human tracheobronchial airways. Aerosol Sci Tech, 2005, 39: 492-500.
8. Zhou Y, Su W C, Cheng Y S. Fiber deposition in the tracheobronchial region: Deposition equations. Inhal Toxicol, 2008, 20: 1191-1198.
9. Hofmann W, Koblinger L. Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure. J Aerosol Sci, 1990, 21: 661-674.
10. Sturmand R, Hofmann W. 3D-visualization of particle deposition patterns in the human lung generated by Monte Carlo modeling: Methodology and applications. Comput Biol Med, 2005, 35: 41-56.
11. Longest P W, Oldham M J. Mutual enhancements of CFD modeling and experimental data: A case study of 1 μm particle deposition in a branching airway model. Inhal Toxicol, 2006, 18: 761-771.
12. Zhang Z, Kleinstreuer C, Kim C S. Comparison of analytical and CFD models with regard to micron particle deposition in a human 16-generation tracheobronchial airway model. J Aerosol Sci, 2009, 40: 16-28.
13. Jin H H, Fan J R, Zeng M J, et al. Large eddy simulation of inhaled particle deposition within the human upper respiratory tract. J Aerosol Sci, 2007, 38: 257-268.
14. Yeh H C, Schum G M. Models of human lung airways and their application to inhaled particle deposition. Bull Math Biol, 1980, 42: 461-480.
15. Wilcox D C. Turbulence Modeling for CFD. 2nd ed. La Cañada, CA: DCW Industries Inc, 1998.
16. Clift R, Grace J R, Weber M E. Bubbles, Drops and Particles. New York: Academic Press, 1978.
17. Balashazy I, Hofmann W, Martonen T B. Inertial impaction and gravitational deposition of aerosols in curved tube and airway bifurcations. Aerosol Sci Tech, 1990, 13: 308-321.
18. Chan T L, Lippmann M. Experimental measurements and empirical modeling of the regional deposition of inhaled particles in humans. Am Ind Hyg Assoc J, 1980, 41: 399-409.
19. Asgharian B, Price O T. Airflow distribution in the human lung and its influence on particle deposition. Inhal Toxicol, 2006, 18: 795-801.
20. Subramaniam R P, Asgharian B, Freijer J I, et al. Analysis of lobar differences in particle deposition in the human lung. Inhal Toxicol, 2003, 15: 1-21.