Spider silk constructs enhance axonal regeneration and remyelination in long nerve defects in sheep

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Radtke, Christine ^a   Allmeling, Christina ^a   Waldmann, Karl Heinz ^b   Reimers, Kerstin ^a   Thies, Kerstin ^b   Schenk, Henning C ^b   Hillmer, Anja ^a   Guggenheim, Merlin ^c   Brandes, Gudrun ^a   Vogt, Peter M ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN; PROTEIN ANTIBODY; S100 ANTIBODY; SODIUM CHANNEL NAV1.6; UNCLASSIFIED DRUG; TISSUE SCAFFOLD;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOTRANSPLANTATION; CELL MIGRATION; COMPOSITE MATERIAL; CONTROLLED STUDY; FEMALE; INTERMETHOD COMPARISON; NERVE FIBER REGENERATION; NERVE INJURY; NERVE TRANSPLANTATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROFILAMENT; NONHUMAN; RANVIER NODE; REMYELINIZATION; SCHWANN CELL; SHEEP; SILK; SPIDER SILK; TIBIAL NERVE; VEIN GRAFT; ANIMAL; CHEMISTRY; CONVALESCENCE; DRUG EFFECT; EVALUATION; INJURY; METABOLISM; MYELIN SHEATH; MYELINATED NERVE; NERVE FIBER; NERVE REGENERATION; PERIPHERAL NERVE; PERIPHERAL NEUROPATHY; PHYSIOLOGY; SPIDER; TRANSPLANTATION; UPREGULATION;

ARANEAE; OVIS ARIES;

ANIMALS; AXONS; FEMALE; MYELIN SHEATH; NERVE FIBERS, MYELINATED; NERVE REGENERATION; PERIPHERAL NERVES; PERIPHERAL NERVOUS SYSTEM DISEASES; RECOVERY OF FUNCTION; SHEEP, DOMESTIC; SILK; SPIDERS; TIBIAL NERVE; TISSUE SCAFFOLDS; UP-REGULATION;

EID: 79952133242     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016990     Document Type: Article

References (34)

1. Fields RD, Le Beau JM, Longo FM, Ellisman MH, (1989) Nerve regeneration through artificial tubular implants. Prog Neurobiol 33 (2): 87-134.
2. Keeley R, Atagi T, Sabelman E, Padilla J, Kadlcik S, et al. (1993) Peripheral nerve regeneration across 14-mm gaps: a comparison of autograft and entubulation repair methods in the rat. J Reconstr Microsurg 9 (5): 349-58.
3. Lundborg G, Dahlin L, Dohi D, Kanje M, Terada N, (1997) A new type of bioartificial nerve graft for bridging extended defects in nerves. J Hand Surg Br 22 (3): 299-303.
4. Lundborg G, Rosen B, Dahlin L, Holmberg J, Rosen I, (2004) Tubular repair of the median or ulnar nerve in the human forearm: a 5-year follow-up. J Hand Surg Br 29 (2): 100-7.
5. Hashimoto T, Suzuki Y, Kitada M, Kataoka K, Wu S, et al. (2002) Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Exp Brain Res 146 (3): 356-68.
6. Itoh S, Suzuki M, Yamaguchi I, Takakuda K, Kobayashi H, et al. (2003) Development of a nerve scaffold using a tendon chitosan tube. Artif Organs 27 (12): 1079-88.
7. Itoh S, Yamaguchi I, Suzuki M, Ichinose S, Takakuda K, et al. (2003) Hydroxyapatite-coated tendon chitosan tubes with adsorbed laminin peptides facilitate nerve regeneration in vivo. Brain Res 993 (1-2): 111-23.
8. Evans GR, Brandt K, Katz S, Chauvin P, Otto L, et al. (2002) Bioactive poly(L-lactic acid) conduits seeded with Schwann cells for peripheral nerve regeneration. Biomaterials 23 (3): 841-8.
9. Matsumoto K, Ohnishi K, Kiyotani T, Sekine T, Ueda H, et al. (2000) Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)-collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves. Brain Res 868 (2): 315-28.
10. Young RC, Wiberg M, Terenghi G, (2002) Poly-3-hydroxybutyrate (PHB): a resorbable conduit for long-gap repair in peripheral nerves. Br J Plast Surg 55 (3): 235-40.
11. Chiono V, Tonda-Turo C, Ciardelli G, (2009) Chapter 9: Artificial scaffolds for peripheral nerve reconstruction. Int Rev Neurobiol 87: 173-98.
12. Ciardelli G, Chiono V, (2006) Materials for peripheral nerve regeneration. Macromol Biosci 6 (1): 13-26.
13. Battiston B, Raimondo S, Tos P, Gaidano V, Audisio C, et al. (2009) Chapter 11 Tissue Engineering of Peripheral Nerves Int Rev Neurobiol 87: 227-49.
14. Chiono V, Vozzi G, Vozzi F, Salvadori C, Dini F, et al. (2009) Melt-extruded guides for pe ripheral nerve regeneration. Part I: Poly(epsilon-caprolactone. Biomed Microdevices Epub ahead of print.
15. Cunniff PM, Fossey SA, Auerbach MA, (1995) Mechanical and thermal properties of dragline silk from the spider Nephila. Polym Adv Technol 5: 401-10.
16. Vollrath F, (2000) Strength and structure of spider's silks. J Biotechnol 74 (2): 67-83.
17. Allmeling C, Jokuszies A, Reimers K, Kall S, Vogt PM, (2006) Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduit. J Cell Mol Med 10 (3): 770-7.
18. Allmeling C, Jokuszies A, Reimers K, Kall S, Choi CY, et al. (2008) Spider silk fibres in artificial nerve constructs promote peripheral nerve regeneration. Cell Prolif 41 (3): 408-20.
19. Radtke C, Akiyama Y, Lankford KL, Vogt PM, Krause DS, et al. (2005) Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons. Neurosci Lett 387 (2): 85-9.
20. Steiss JE, Argue CK, (1987) Normal values for radial, peroneal and tibial motor nerve conduction velocities in adult sheep, with comparison to adult dogs. Vet Res Commun 11 (3): 243-52.
21. Rivlin M, Sheikh E, Isaac R, Beredjiklian PK, (2010) The role of nerve allografts and conduits for nerve injuries. Hand Clin 26 (3): 435-46.
22. Arai T, Lundborg G, Dahlin LB, (2000) Bioartificial nerve graft for bridging extended nerve defects in rat sciatic nerve based on resorbable guiding filaments. Scand J Plast Reconstr Surg Hand Surg 34 (2): 101-8.
23. Vleggeert-Lankamp CL, (2007) The role of evaluation methods in the assessment of peripheral nerve regeneration through synthetic conduits: a systematic review.Laboratory investigation. J Neurosurg 107 (6): 1168-89.
24. Lütschg J, Ludin H-P, (1981) Electromyographic findings in patients after recovery from peripheral nerve lesions and poliomyelitis. J Neurol 225: 25-32.
25. Sasaki M, Black JA, Lankford KL, Tokuno HA, Waxman SG, et al. (2006) Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord. J Neurosci 26 (6): 1803-12.
26. Altman GH, Diaz F, Jakuba C, Calabro T, Horan RL, et al. (2003) Silk-based biomaterials. Biomaterials 24 (3): 401-16.
27. Yang Y, Ding F, Wu J, Hu W, Liu J, et al. (2007) Development and evaluation of silk fibroin-based nerve grafts used for peripheral nerve regeneration. Biomaterials 28 (36): 5526-35.
28. Lovett ML, Cannizzaro CM, Vunjak-Novakovic G, Kaplan DL, (2008) Gel spinning of silk tubes for tissue engineering. Biomaterials 29 (35): 4650-7.
29. Wang CY, Zhang KH, Fan CY, Mo XM, Ruan HJ, et al. (2010) Aligned natural-synthetic polyblend nanofibers for peripheral nerve regeneration. Acta Biomater Epub ahead of print.
30. Mandal BB, Das S, Choudhury K, Kundu SC, (2010) Implication of silk film RGD availability and surface roughness on cytoskeletal organization and proliferation of primary rat bone marrow cells. Tissue Eng Part A 16 (7): 2391-403.
31. Radtke C, Aizer AA, Agulian SK, Lankford KL, Vogt PM, et al. (2009) Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair. Brain Res 1254: 10-7.
32. Madduri S, Papaloizos M, Gander B, (2010) Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration. Biomaterials 31 (8): 2323-34.
33. Uebersax L, Mattotti M, Papaloizos M, Merkle HP, Gander B, et al. (2007) Silk fibroin matrices for the controlled release of nerve growth factor (NGF). Biomaterials 28 (30): 4449-60.
34. Lankford KL, Imaizumi T, Honmou O, Kocsis JD, (2002) A quantitative morphometric analysis of rat spinal cord remyelination following transplantation of allogenic Schwann cells. J Comp Neurol 443 (3): 259-74.