The new medical challenge: Why NDM-1? Why Indian?

Expert Review of Anti-Infective Therapy

Volumn 9, Issue 2, 2011, Pages 137-141

  Walsh, Timothy R ^a   Toleman, Mark A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Enterobacteriaceae; India; Indian subcontinent; multidrug resistance; NDM 1

Indexed keywords

CARBAPENEM; CARBAPENEMASE; EXTENDED SPECTRUM BETA LACTAMASE; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; BACTERIAL TRANSMISSION; DRUG USE; EDITORIAL; ENTEROBACTERIACEAE; ENVIRONMENTAL SANITATION; HUMAN; INDIA; KLEBSIELLA PNEUMONIAE; MULTIDRUG RESISTANCE; NONHUMAN; PLASMID; SEWAGE;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CARBAPENEMS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS; INDIA; MICROBIAL SENSITIVITY TESTS;

EID: 79952130206     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.10.159     Document Type: Editorial

References (44)

1. Walsh TR, Toleman MA, Poirel L, Nordmann P. Metallo-β-lactamases: the quiet before the storm? Clin. Microbiol. Rev. 18, 306-325 (2005).
2. Patzer JA, Walsh TR, Weeks J, Dzierzanowska D, Toleman MA. Emergence and persistence of integron structures harbouring VIM genes in the Children's Memorial Health Institute, Warsaw, Poland, 1998-2006. J. Antimicrob. Chemother. 63, 269-273 (2009).
3. Quinones-Falconi F, Galicia-Velasco M, Marchiaro P et al. Emergence of Pseudomonas aeruginosa strains producing metallo-β-lactamases of the IMP-15 and VIM-2 types in Mexico. Clin. Microbiol. Infect. 16(2), 126-131 (2009).
4. Yakupogullari Y, Poirel L, Bernabeu S, Kizirgil A, Nordmann P. Multidrug-resistant Pseudomonas aeruginosa isolate co-expressing extended-spectrum β-lactamase PER-1 and metallo-β-lactamase VIM-2 from Turkey. J. Antimicrob. Chemother. 61, 221-222 (2008).
5. Yong, D, Toleman MA, Giske CG et al. Characterization of a new metallo-β-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob. Agents Chemother. 53, 5046-5054 (2009). The first genetic description of New Delhi metallo-β-lactamase-1 (NDM-1).
6. Deshpande P, Rodrigues C, Shetty A, Kapadia F, Hedge A, Soman R. New Delhi metallo-β-lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised. J. Assoc. Physicians India 58, 147-149 (2010).
7. Ghafur AK. An obituary on the death of antibiotics! J. Assoc. Physicians India 58, 143-144 (2010). A frank and bold synopsis of some of the problems facing India in controlling NDM-1.
8. Tangden T, Cars O, Melhus A, Lowdin, E. Foreign travel is a major risk factor for colonization with Escherichia coli producing CTX-M-type extended-spectrum β-lactamases: a prospective study with Swedish volunteers. Antimicrob. Agents Chemother. 54, 3564-3568 (2010). An interesting study examining acquistion of resistance types when traveling.
9. Hawser SP, Bouchillon SK, Hoban DJ et al. Emergence of high levels of extended-spectrum-β-lactamase-producing Gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. Antimicrob. Agents Chemother. 53, 3280-3284 (2009). A well-conducted study revealing disturbing data from countries where resistance is not often studied.
10. Jamwal P, Mittal AK, Mouchel JM. Efficiency evaluation of sewage treatment plants with different technologies in Delhi (India). Environ. Monit. Assess. 153, 293-305 (2009).
11. Castanheira M, Deshpande LM, Mathai D, Bell JM, Jones RN, Mendes RE. Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY antimicrobial surveillance program (2006-2007). Antimicrob Agents Chemother. DOI:10.1128/AAC.01497-10 (2010) (Epub ahead of print).
12. Diwan V, Tamhankar AJ, Khandal RK et al. Antibiotics and antibiotic-resistant bacteria in waters associated with a hospital in Ujjain, India. BMC Public Health 10, 414 (2010).
13. Dorr T, Vulic M, Lewis K. Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biol. 8, e1000317 (2010).
14. Lopez E, Blazquez, J. Effect of subinhibitory concentrations of antibiotics on intrachromosomal homologous recombination in Escherichia coli. Antimicrob. Agents Chemother. 53, 3411-3415 (2009).
15. Beaber JW, Hochhut B, Waldor MK. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 427, 72-74 (2004). A beautiful and under-rated study examining the sinister effects of fluoroquinolones in mobiling bacterial genetic elements.
16. Kumarasamy KK, Toleman MA, Walsh TR et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10(9), 597-602 (2010). The start of all the commotion concerning the superbug NDM-1.
17. Goel N, Wattal C. New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 10, 751; author reply 752-754 (2010).
18. New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 10, 749-750; author reply 752-754 (2010).
19. Sirohi B. New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 10, 750; author reply 752-754 (2010).
20. Tempe DK. New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 10, 750-751; author reply 752-754 (2010).
21. Centers for Disease Control and Prevention. Detection of Enterobacteriaceae isolates carrying metallo-β-lactamase - United States, 2010. MMWR 59, 750 (2010).
22. Hsueh PR. New Delhi metallo-β-lactamase-1 (NDM-1): an emerging threat among Enterobacteriaceae. J. Formos. Med. Assoc. 109, 685-687 (2010).
23. Rolain JM, Parola P, Cornaglia G. New Delhi metallo-β-lactamase (NDM-1): towards a new pandemia? Clin. Microbiol. Infect. 16, 1699-1701 (2010).
24. Leverstein-van Hall MA, Stuart JC, Voets GM et al. Carbapenem-resistant Klebsiella pneumoniae following foreign travel. Ned. Tijdschr. Geneeskd 154, A2013 (2010).
25. Bruhn C. NDM-1-producing bacteria-danger due to 'super germs'?. Dtsch Med. Wochenschr. 135, p38 (2010).
26. Poirel L, Ros A, Carricajo A et al. Extremely drug-resistant Citrobacter freundii identified in a patient returning from India and producing NDM-1 and other carbapenemases. Antimicrob. Agents Chemother. 55(1), 447-448 (2010).
27. Poirel L, Lagrutta E, Taylor P, Pham J, Nordmann P. Emergence of metallo-β-lactamase NDM-1-producing multidrugresistant Escherichia coli in Australia. Antimicrob. Agents Chemother. 54, 4914-4916 (2010).
28. Shaw MT, Leggat PA, Chatterjee S. Travelling to India for the Delhi XIX Commonwealth Games 2010. Travel. Med. Infect. Dis. 8, 129-138 (2010).
29. Ensink JH, Blumenthal UJ, Brooker S. Wastewater quality and the risk of intestinal nematode infection in sewage farming families in hyderabad, India. Am. J. Trop. Med. Hyg. 79, 561-567 (2008).
30. Million Death Study Collaborators. Causes of neonatal and child mortality in India: a nationally representative mortality survey. Lancet 376(9755), 1853-1860 (2010). An eye-opening account on child death rates in India.
31. Sarma JB, Ahmed GU. Prevalence and risk factors for colonisation with extended spectrum β-lactamase producing enterobacteriacae vis-a-vis usage of antimicrobials. Indian. J. Med. Microbiol. 28, 217-220 (2010). Interesting study linking extended spectrum β-lactamase carriage with extended spectrum β-lactamase sewage rates.
32. Pandey AA, Thakre SB, Bhatkule PR. Prescription analysis of pediatric outpatient practice in Nagpur city. Indian J. Community Med. 35, 70-73 (2010).
33. Sengupta N, Alam SI, Kumar RB, Singh L. Diversity and antibiotic susceptibility pattern of cultivable anaerobic bacteria from soil and sewage samples of India. Infect. Genet. Evol. 11(1), 64-77 (2010).
34. Nagshetty K, Channappa ST, Gaddad SM. Antimicrobial susceptibility of Salmonella Typhi in India. J. Infect. Dev. Ctries 4, 70-73 (2010).
35. Shakibaie MR, Jalilzadeh KA, Yamakanamardi SM. Horizontal transfer of antibiotic resistance genes among Gram negative bacteria in sewage and lake water and influence of some physico-chemical parameters of water on conjugation process. J. Environ. Biol. 30, 45-49 (2009).
36. Bhandare S, Paturkar AM, Waskar VS, Zende RJ. Prevalence of microorganisms of hygienic interest in an organized abattoir in Mumbai, India. J. Infect. Dev. Ctries 4, 454-458 (2010).
37. Webster PC. Global action urged in response to new breed of drug-resistant bacteria. CMAJ 182, 1602-1603 (2010).
38. MacPherson DW, Gushulak BD, Baine WB et al. Population mobility, globalization, and antimicrobial drug resistance. Emerging Infect. Dis. 15, 1727-1732 (2009).
39. Boucher HW, Talbot GH, Bradley JS et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin. Infect. Dis. 48, 1-12 (2009).
40. Rice LB. Emerging issues in the management of infections caused by multidrug-resistant Gram-negative bacteria. Cleve. Clin. J. Med. 74(Suppl. 4), S12-S20 (2007).
41. Rice LB. Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa. Clin. Infect. Dis. 43(Suppl. 2), S100-S105 (2006).
42. Rice LB. Unmet medical needs in antibacterial therapy. Biochem. Pharmacol. 71, 991-995, (2006).
43. International travel increasing spread of new drug-resistant bacteria: is this the end of antibiotics? www.physorg.com/news200670948.html
44. Lakhani N. NHS 'could save millions' by flying patients to India. The Independent www.independent.co.uk/life-style/healthand-families/health-news/nhs- could-save-millions-by-flyingpatients-to-india-1870215.html