A CD133-related gene expression signature identifies an aggressive glioblastoma subtype with excessive mutations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 4, 2011, Pages 1591-1596

  Yan, Xiaowei ^a   Ma, Li ^a   Yi, Danielle ^a   Yoon, Jae Geun ^b   Diercks, Alan ^a   Foltz, Gregory ^a,b   Price, Nathan D ^c   Hood, Leroy E ^a   Tian, Qiang ^a,d  

^a INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^b SWEDISH MEDICAL CENTER   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Molecular profiling; Systems biology

Indexed keywords

CD133 ANTIGEN;

ARTICLE; CANCER STEM CELL; CANCER SURVIVAL; CELL SUBPOPULATION; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENETIC TRANSCRIPTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN GENOME; NEURAL STEM CELL; PRIORITY JOURNAL; TRANSCRIPTOMICS;

ANTIGENS, CD; CLUSTER ANALYSIS; EMBRYONIC STEM CELLS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASTIC STEM CELLS; NEURAL STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; TUMOR CELLS, CULTURED;

EID: 79952119592     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1018696108     Document Type: Article

References (29)

1. Lapidot T, et al. (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367:645-648. (Pubitemid 24067706)
2. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100:3983-3988. (Pubitemid 36418143)
3. Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105-111. (Pubitemid 33041634)
4. Singh SK, et al. (2004) Identification of human brain tumour initiating cells. Nature 432:396-401. (Pubitemid 39551674)
5. Furnari FB, et al. (2007) Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes Dev 21:2683-2710. (Pubitemid 350070717)
6. Anonymous; Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068.
7. Parsons DW, et al. (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-1812.
8. O'Brien CA, Pollett A, Gallinger S, Dick JE (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445:106-110. (Pubitemid 46067310)
9. Singh SK, et al. (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63:5821-5828. (Pubitemid 37187480)
10. Bao S, et al. (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760. (Pubitemid 44949604)
11. Liu R, et al. (2007) The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 356:217-226. (Pubitemid 46143225)
12. Ben-Porath I, et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40:499-507. (Pubitemid 351601215)
13. Beier D, et al. (2007) CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 67:4010-4015. (Pubitemid 46815044)
14. Shmelkov SV, et al. (2008) CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest 118:2111-2120. (Pubitemid 351872330)
15. Chen R, et al. (2010) A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell 17:362-375.
16. Verhaak RG, et al.; Cancer Genome Atlas Research Network (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98-110.
17. Setlur SR, et al. (2007) Integrative microarray analysis of pathways dysregulated in metastatic prostate cancer. Cancer Res 67:10296-10303. (Pubitemid 350070803)
18. Skottman H, et al. (2005) Gene expression signatures of seven individual human embryonic stem cell lines. Stem Cells 23:1343-1356. (Pubitemid 41504922)
19. Lee J, et al. (2006) Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9:391-403. (Pubitemid 43668737)
20. Sun L, et al. (2006) Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 9:287-300.
21. Phillips HS, et al. (2006) Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9:157-173. (Pubitemid 43357943)
22. Murat A, et al. (2008) Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol 26:3015-3024.
23. Sotiriou C, et al. (2006) Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst 98:262-272. (Pubitemid 43264710)
24. Sanchez-Carbayo M, Socci ND, Lozano J, Saint F, Cordon-Cardo C (2006) Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol 24:778-789. (Pubitemid 46622045)
25. Tu LC, Foltz G, Lin E, Hood L, Tian Q (2009) Targeting stem cells-clinical implications for cancer therapy. Curr Stem Cell Res Ther 4:147-153.
26. Price ND, Foltz G, Madan A, Hood L, Tian Q (2008) Systems biology and cancer stem cells. J Cell Mol Med 12:97-110.
27. Lottaz C, et al. (2010) Transcriptional profiles of CD133+ and CD133- glioblastomaderived cancer stem cell lines suggest different cells of origin. Cancer Res 70:2030-2040.
28. Garcia JL, et al. (2010) Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas. BMC Cancer 10:454.
29. Foltz G, et al. (2006) Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Cancer Res 66:6665-6674. (Pubitemid 44085623)