Gray matter reduction associated with systemic chemotherapy for breast cancer: A prospective MRI study

Breast Cancer Research and Treatment

Volumn 123, Issue 3, 2010, Pages 819-828

  McDonald, Brenna C ^a,b   Conroy, Susan K ^a   Ahles, Tim A ^b,c   West, John D ^a   Saykin, Andrew J ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Adjuvant chemotherapy; Brain; Breast cancer; Magnetic resonance imaging; Neuroimaging

Indexed keywords

ANASTROZOLE; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; GOSERELIN; LETROZOLE; PACLITAXEL; PSYCHOTROPIC AGENT; TAMOXIFEN; TRASTUZUMAB;

ADULT; ARTICLE; BRAIN DISEASE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG USE; FEMALE; FRONTAL CORTEX; GRAY MATTER ALTERATION; GRAY MATTER DENSITY; HUMAN; IMAGE ANALYSIS; LONGITUDINAL STUDY; MENTAL DISEASE; NERVOUS SYSTEM PARAMETERS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; PROSPECTIVE STUDY; SIDE EFFECT; TEMPORAL CORTEX; THALAMUS; TREATMENT DURATION; TREATMENT RESPONSE; VOXEL BASED MORPHOMETRY; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; BRAIN; BREAST TUMOR; DRUG EFFECT; MIDDLE AGED; PATHOLOGY; TIME; TREATMENT OUTCOME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; FEMALE; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; NEOPLASM STAGING; PROSPECTIVE STUDIES; RADIOTHERAPY, ADJUVANT; TIME FACTORS; TREATMENT OUTCOME;

EID: 79952118242     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1088-4     Document Type: Article

References (42)

1. Ahles TA, Saykin AJ (2007) Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer 7:192-201. doi:10.1038/nrc2073
2. Ahles TA, Saykin AJ, McDonald BC, Furstenberg CT, Cole BF, Hanscom BS, Mulrooney TJ, Schwartz GN, Kaufman PA (2008) Cognitive function in breast cancer patients prior to adjuvant treatment. Breast Cancer Res Treat 110:143-152 (Pubitemid 351793851)
3. Anderson-Hanley C, Sherman ML, Riggs R, Agocha VB, Compas BE (2003) Neuropsychological effects of treatments for adults with cancer: A meta-Analysis and review of the literature. J Int Neuropsychol Soc 9:967-982 (Pubitemid 37428441)
4. Ashburner J, Friston KF (2000) Voxel-based morphometry-The methods. Neuroimage 11:805-821
5. Ashburner J, Friston KJ (2001) Why voxel-based morphometry should be used. Neuroimage 14:1238-1243 (Pubitemid 33124172)
6. Barona A, Reynolds C, Chastain R (1984) A demographically based index of pre-morbid intelligence for the WAIS-R. J Consult Clin Psychol 52:885-887
7. Castellon SA, Ganz PA, Bower JE, Petersen L, Abraham L, Greendale GA (2004) Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen. J Clin Exp Neuropsychol 26:955-969 (Pubitemid 39577316)
8. Castro-Fornieles J, Bargallo N, Lazaro L, Andres S, Falcon C, Plana MT, Junque C (2009) A cross-sectional and follow-up voxel-based morphometric MRI study in adolescent anorexia nervosa. J Psychiatr Res 43:331-340
9. Collins B, Mackenzie J, Stewart A, Bielajew C, Verma S, Collins B, Mackenzie J, Stewart A, Bielajew C, Verma S (2009) Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatment. Psychooncology 18:134-143
10. Correa DD, Ahles TA (2008) Neurocognitive changes in cancer survivors. Cancer J 14:396-400
11. Eberling JL, Wu C, Tong-Turnbeaugh R, Jagust WJ (2004) Estrogen-And tamoxifen-Associated effects on brain structure and function. Neuroimage 21:364-371 (Pubitemid 38115027)
12. Ferguson RJ, McDonald BC, Saykin AJ, Ahles TA (2007) Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy. J Clin Oncol 25: 3866-3870. doi:10.1200/JCO.2007.10.8639 (Pubitemid 47477262)
13. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14:21-36 (Pubitemid 32552740)
14. Hakamata Y, Matsuoka Y, Inagaki M, Nagamine M, Hara E, Imoto S, Murakami K, Kim Y, Uchitomi Y (2007) Structure of orbitofrontal cortex and its longitudinal course in cancer-related post-Traumatic stress disorder. Neurosci Res 59:383-389. doi: 10.1016/j.neures.2007.08.012 (Pubitemid 350007812)
15. Hermelink K, Henschel V, Untch M, Bauerfeind I, Lux MP, Munzel K (2008) Short-Term effects of treatment-induced hormonal changes on cognitive function in breast cancer patients: results of a multicenter, prospective, longitudinal study. Cancer 113:2431-2439
16. Inagaki M, Yoshikawa E, Matsuoka Y, Sugawara Y, Nakano T, Akechi T, Wada N, Imoto S, Murakami K, Uchitomi Y (2007) Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer 109:146-156 (Pubitemid 46120202)
17. Jenkins VA, Ambroisine LM, Atkins L, Cuzick J, Howell A, Fallowfield LJ, Jenkins VA, Ambroisine LM, Atkins L, Cuzick J, Howell A, Fallowfield LJ (2008) Effects of anastrozole on cognitive performance in postmenopausal women: A randomised, double-blind chemoprevention trial (IBIS II). Lancet Oncol 9:953-961
18. Jim HSL, Donovan KA, Small BJ, Andrykowski MA, Munster PN, Jacobsen PB (2009) Cognitive functioning in breast cancer survivors: A controlled comparison. Cancer 115:1183-1776
19. Koros C, Papalexi E, Anastasopoulos D, Kittas C, Kitraki E (2007) Effects of AraC treatment on motor coordination and cerebellar cytoarchitecture in the adult rat. A possible protective role of NAC. Neurotoxicology 28:83-92 (Pubitemid 46187262)
20. Li C-Q, Liu D, Huang L, Wang H, Zhang J-Y, Luo X-G (2008) Cytosine arabinoside treatment impairs the remote spatial memory function and induces dendritic retraction in the anterior cingulate cortex of rats. Brain Res Bull 77:237-240
21. McDonald BC, Saykin AJ, Ahles TA (2008) Brain imaging investigation of chemotherapy-induced neurocognitive changes. In: Meyers CA, Perry JR (eds) Cognition and Cancer. Cambridge University Press, Cambridge, MA, pp 19-32
22. Monkul ES, Matsuo K, Nicoletti MA, Dierschke N, Hatch JP, Dalwani M, Brambilla P, Caetano S, Sassi RB, Mallinger AG, Soares JC (2007) Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study. Neurosci Lett 429:7-11 (Pubitemid 350116344)
23. Ouimet LA, Stewart A, Collins B, Schindler D, Bielajew C (2009) Measuring neuropsychological change following breast cancer treatment: An analysis of statistical models. J Clin Exp Neuropsychol Off J Int Neuropsychol Soc 31:73-89
24. Palmer JL, Trotter T, Joy AA, Carlson LE (2008) Cognitive effects of Tamoxifen in pre-menopausal women with breast cancer compared to healthy controls. J Cancer Surviv 2:275-282
25. Quesnel C, Savard J, Ivers H (2009) Cognitive impairments associated with breast cancer treatments: results from a longitudinal study. Breast Cancer Res Treat 116:113-123
26. Radloff LS (1977) The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1:385-401
27. Risacher SL, Saykin AJ, West JD, Shen L, Firpi HA, McDonald BC, Alzheimer's Disease Neuroimaging I (2009) Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort. Curr Alzheimer Res 6:347-361
28. Saykin AJ, Ahles TA, McDonald BC (2003) Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives. Semin Clin Neuropsychiatry 8:201-216 (Pubitemid 37474731)
29. Saykin AJ, Wishart HA, Rabin LA, Santulli RB, Flashman LA, West JD, McHugh TL, Mamourian AC (2006) Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology 67:834-842 (Pubitemid 44394199)
30. Schilder CM, Seynaeve C, Beex LV, Boogerd W, Linn SC, Gundy CM, Huizenga HM, Nortier JW, van de Velde CJ, van Dam FS, Schagen SB (2010) Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial. J Clin Oncol 28:1294-1300
31. Silverman DH, Dy CJ, Castellon SA, Lai J, Pio BS, Abraham L, Waddell K, Petersen L, Phelps ME, Ganz PA (2007) Altered frontocortical, cerebellar, and basal ganglia activity in adjuvanttreated breast cancer survivors 5-10 years after chemotherapy. Breast Cancer Res Treat 103:303-311 (Pubitemid 46944511)
32. Spielberger CD (1983) State-Trait Anxiety Inventory. Consulting Psychologists Press, Palo Alto
33. Stewart A, Bielajew C, Collins B, Parkinson M, Tomiak E (2006) A meta-Analysis of the neuropsychological effects of adjuvant chemotherapy treatment in women treated for breast cancer. Clin Neuropsychol 20:76-89
34. Strick PL, Dum RP, Fiez JA (2009) Cerebellum and nonmotor function. Annu Rev Neurosci 32:413-434
35. Vardy J, Wefel JS, Ahles T, Tannock IF, Schagen SB (2008) Cancer and cancer-Therapy related cognitive dysfunction: An international perspective from the Venice cognitive workshop. Ann Oncol 19:623-629. doi:10.1093/annonc/mdm500 (Pubitemid 351461030)
36. Wagner L, Sweet J, Butt Z, Beaumont J, Havlin K, Sabatino T, Cella D (2006) Trajectory of cognitive impairment during breast cancer treatment: A prospective analysis. J Clin Oncol 24:S8500
37. Wefel JS, Lenzi R, Theriault R, Buzdar AU, Cruickshank S, Meyers CA (2004) 'Chemobrain' in breast carcinoma A prologue. Cancer 101:466-475
38. Weis J, Poppelreuter M, Bartsch HH (2009) Cognitive deficits as long-Term side-effects of adjuvant therapy in breast cancer patients: 'subjective' complaints and 'objective' neuropsychological test results. Psychooncology 18:775-782
39. Wishart HA, Saykin AJ, McAllister TW, Rabin LA, McDonald BC, Flashman LA, Roth RM, Mamourian AC, Tsongalis GJ, Rhodes CH (2006) Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele. Neurology 67: 1221-1224. doi:10.1212/01.wnl.0000238079.00472.3a (Pubitemid 44563831)
40. Yamada TH, Denburg NL, Beglinger LJ, Schultz SK (2010) Neuropsychological outcomes of older breast cancer survivors: cognitive features ten or more years after chemotherapy. J Neuropsychiatry Clin Neurosci 22:48-54
41. Yasuda CL, Valise C, Saude AV, Pereira AR, Pereira FR, Ferreira Costa AL, Morita ME, Betting LE, Castellano G, Mantovani Guerreiro CA, Tedeschi H, de Oliveira E, Cendes F (2010) Dynamic changes in white and gray matter volume are associated with outcome of surgical treatment in temporal lobe epilepsy. Neuroimage 49:71-79
42. Yoshikawa E, Matsuoka Y, Yamasue H, Inagaki M, Nakano T, Akechi T, Kobayakawa M, Fujimori M, Nakaya N, Akizuki N, Imoto S, Murakami K, Kasai K, Uchitomi Y (2006) Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis. Biol Psychiatry 59:707-712