Does metformin increase the risk of fatal or nonfatal lactic acidosis?

American Family Physician

Volumn 82, Issue 9, 2010, Pages 1068-1070

  Cayley Jr , William E ^a  

^a UNIVERSITY OF WISCONSIN EAU CLAIRE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; METFORMIN; PHENFORMIN; ANTIDIABETIC AGENT;

ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL (TOPIC); CREATININE BLOOD LEVEL; DISEASE PREDISPOSITION; DRUG ACTIVITY; DRUG CONTRAINDICATION; DRUG SAFETY; HEART INFARCTION; HUMAN; LACTIC ACIDOSIS; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK REDUCTION; SYSTEMATIC REVIEW (TOPIC); AGED; CHEMICALLY INDUCED DISORDER; EVIDENCE BASED MEDICINE; MIDDLE AGED; RISK;

ACIDOSIS, LACTIC; AGED; DIABETES MELLITUS, TYPE 2; EVIDENCE-BASED MEDICINE; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; MIDDLE AGED; RISK;

EID: 79952117242     PISSN: 0002838X     EISSN: 0002838X     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Salpeter SR, Greyber E, Pasternak GA, Salpeter EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev. 2010;(1):CD002967.
2. Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32(1):193-203.
3. Selvin E, Bolen S, Yeh HC, et al. Cardiovascular outcomes in trials of oral diabetes medications: a systematic review. Arch Intern Med. 2008;168(19):2070-2080.
4. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group [published correction appears in Lancet. 1998;352(9139):1558]. Lancet. 1998;352(9131):854-865.
5. Rachmani R, Slavachevski I, Levi Z, Zadok B, Kedar Y, Ravid M. Metformin in patients with type 2 diabetes mellitus: reconsideration of traditional contraindications. Eur J Intern Med. 2002;13(7):428.