Performance of messenger RNAs circulating in maternal blood in the prediction of preeclampsia at 10-14 weeks

American Journal of Obstetrics and Gynecology

Volumn 203, Issue 6, 2010, Pages 575.e1-575.e7

  Farina, Antonio ^a,b,c   Zucchini, Cinzia ^a   Sekizawa, Akihiko ^b   Purwosunu, Yuditiya ^b   De Sanctis, Paola ^a   Santarsiero, Giuseppe ^a   Rizzo, Nicola ^a   Morano, Danila ^a   Okai, Takashi ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CIPTO MANGUNKUSUMO HOSPITAL   (Indonesia)

Author keywords

Logistic regression; Maternal blood; MRNA; Preeclampsia; Screening

Indexed keywords

ENDOGLIN; FMS RELATED TYROSINE KINASE 1; MESSENGER RNA; PLACENTA PROTEIN; PLACENTAL GROWTH FACTOR; PLACENTAL GROWTH FACTOR 13; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; VASCULOTROPIN RECEPTOR 1;

ADULT; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; FALSE POSITIVE RESULT; FEMALE; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MATERNAL BLOOD; PREECLAMPSIA; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; BLOOD; CASE CONTROL STUDY; COMPARATIVE STUDY; FOLLOW UP; PREDICTIVE VALUE; PREGNANCY; PREGNANCY OUTCOME; REFERENCE VALUE; SECOND TRIMESTER PREGNANCY; STATISTICAL MODEL;

ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LOGISTIC MODELS; PRE-ECLAMPSIA; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY PROTEINS; PREGNANCY TRIMESTER, SECOND; REFERENCE VALUES; RISK ASSESSMENT; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 79952117099     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2010.07.043     Document Type: Article

References (26)

1. Walker JJ. Pre-eclampsia. Lancet 2000;356: 1260-5.
2. De Groot CJ, Bloemenkamp KW, Duvekot EJ, et al. Preeclampsia and genetic risk factors for thrombosis: a case-control study. Am J Obstet Gynecol 1999;181:975-80. (Pubitemid 29503626)
3. Myatt L, Miodovnik M. Prediction of preeclampsia. Semin Perinatol 1999;23:45-57. (Pubitemid 29095585)
4. Lambert-Messerlian GM, Silver HM, Petraglia F, et al. Second-trimester levels of maternal serum human chorionic gonadotropin and inhibin a as predictors of preeclampsia in the third trimester of pregnancy. J Soc Gynecol Investig 2000;7:170-4. (Pubitemid 30349162)
5. Halligan A, Bonnar J, Sheppard B, Darling M, Walshe J. Haemostatic, fibrinolytic and endothelial variables in normal pregnancies and preeclampsia. BJOG 1994;101:488-92. (Pubitemid 24210148)
6. Ballegeer V, Spitz B, Kieckens L, Moreau H, Van Assche A, Collen D. Predictive value of increased plasma levels of fibronectin in gestational hypertension. Am J Obstet Gynecol 1989;161:432-6.
7. Cotter AM, Molloy AM, Scott JM, Daly SF. Elevated plasma homocysteine in early pregnancy: a risk factor for the development of severe preeclampsia. Am J Obstet Gynecol 2001;185:781-5. (Pubitemid 32980511)
8. Clausen T, Djurovic S, Brosstad FR, Berg K, Henriksen T. Altered circulating levels of adhesion molecules at 18 weeks' gestation among women with eventual preeclampsia: indicators of disturbed placentation in absence of evidence of endothelial dysfunction? Am J Obstet Gynecol 2000;182:321-5. (Pubitemid 30127342)
9. Chien PF, Arnott N, Gordon A, Owen P, Khan KS. How useful is uterine artery Doppler flow velocimetry in the prediction of pre-eclampsia, intrauterine growth retardation and perinatal death? An overview. BJOG 2000;107:196-208. (Pubitemid 30081585)
10. Purwosunu Y, Sekizawa A, Okazaki S, et al. Prediction of preeclampsia by analysis of cellfree messenger RNA in maternal plasma. Am J Obstet Gynecol 2009;200:386.e1-7.
11. Okazaki S, Sekizawa A, Purwosunu Y, Iwasaki M, Farina A, Okai T. Measurement of mRNA of trophoblast-specific genes in cellular and plasma components of maternal blood. J Med Genet 2006;43:e47
12. Collett D. Modelling binary data. New York, NY: Chapman & Hall; 1999.
13. Shimizu H, Sekizawa A, Purwosunu Y, et al. PP13 mRNA expression in the cellular component of maternal blood as a marker for preeclampsia. Prenat Diagn 2009;29:1231-6.
14. Farina A, Sekizawa A, De Sanctis P, et al. Gene expression in chorionic villous samples at 11 weeks' gestation from women destined to develop preeclampsia. Prenat Diagn 2008;28: 956-61.
15. Papageorghiou AT, Yu CK, Nicolaides KH. The role of uterine artery Doppler in predicting adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol 2004;18:383-96. (Pubitemid 38950046)
16. Conde-Agudelo A, Villar J, Lindheimer M. World Health Organization systematic review of screening tests for preeclampsia. Obstet Gynecol 2004;104:1367-91. (Pubitemid 40458737)
17. Akolekar R, Etchegaray A, Zhou Y, Maiz N, Nicolaides KH. Maternal serum activin at 11-13 weeks of gestation in hypertensive disorders of pregnancy. Fetal Diagn Ther 2009;25:320-7.
18. Poon LC, Staboulidou I, Maiz N, Plasencia W, Nicolaides KH. Hypertensive disorders in pregnancy: screening by uterine artery Doppler at 11-13 weeks. Ultrasound Obstet Gynecol 2009;34:142-8.
19. Poon LC, Kametas NA, Maiz N, Akolekar R, Nicolaides KH. First-trimester prediction of hypertensive disorders in pregnancy. Hypertension 2009;53:812-8.
20. Onwudiwe N, Yu CK, Poon LC, Spiliopoulos I, Nicolaides KH. Prediction of pre-eclampsia by a combination of maternal history, uterine artery Doppler and mean arterial pressure. Ultrasound Obstet Gynecol 2008;32:877-83.
21. Levine RJ, Lam C, Qian C, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006; 355:992-1005. (Pubitemid 44343543)
22. Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004;350:672-83. (Pubitemid 38364626)
23. Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the patho-genesis of preeclampsia. Nat Med 2006;12: 642-9. (Pubitemid 43865232)
24. Enquobahrie DA, Williams MA, Qiu C, Woelk GB, Mahomed K. Maternal plasma transforming growth factor-beta1 concentrations in preeclamptic and normotensive pregnant Zimbabwean women. J Matern Fetal Neonatal Med 2005;17:343-8. (Pubitemid 40992320)
25. Lim JH, Kim SY, Park SY, Yang JH, Kim MY, Ryu HM. Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors. Obstet Gynecol 2008;111:1403-9.
26. Sekizawa A, Purwosunu Y, Farina A, et al. Prediction of preeclampsia by an analysis of placenta-derived cellular mRNA in the blood of pregnant women at 15-20 weeks of gestation. BJOG 2010;117:557-64.