Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector

International Journal of Nanomedicine

Volumn 5, Issue 1, 2010, Pages 455-461

  Azizi, Ebrahim ^a   Namazi, Alireza ^a   Haririan, Ismaeil ^a,c   Fouladdel, Shamileh ^a   Khoshayand, Mohammad R ^b   Shotorbani, Parisa Y ^d   Nomani, Alireza ^a,e   Gazori, Taraneh ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c Biomaterials Research Center (BRC)   (Iran)

^d ISLAMIC AZAD UNIVERSITY   (Iran)

^e ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Agarose gel electrophoresis; Chitosan alginate nanoparticles; Freeze drying; Release profile

Indexed keywords

ALGINIC ACID; BIOPOLYMER; CHITOSAN; EPIDERMAL GROWTH FACTOR RECEPTOR; NANOPARTICLE; PHOSPHATE BUFFERED SALINE; COMPLEMENTARY DNA; GLUCURONIC ACID; HEXURONIC ACID;

AGAR GEL ELECTROPHORESIS; ANTISENSE VECTOR; AQUEOUS SOLUTION; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING; LONG TERM EXPOSURE; NANOANALYSIS; PARTICLE SIZE; PH MEASUREMENT; PROCESS OPTIMIZATION; ZETA POTENTIAL; CHEMISTRY; GENE VECTOR; GENETICS; NANOMEDICINE; NUCLEOTIDE SEQUENCE; PROTO ONCOGENE;

ALGINATES; BASE SEQUENCE; CHITOSAN; DNA, ANTISENSE; DRUG DELIVERY SYSTEMS; DRUG STABILITY; FREEZE DRYING; GENES, ERBB-1; GENETIC VECTORS; GLUCURONIC ACID; HEXURONIC ACIDS; NANOMEDICINE; NANOPARTICLES; PARTICLE SIZE;

EID: 79952115945     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Sarmento B, Ferreira D, Veiga F, Ribeiro A. Characterization of insulin- loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies. Carbohydrate Polymers. 2006;66:1-7.
2. Douglas KL, Tabrizian M. Effect of experimental parameters on the formation of Alginate-Chitosan nanoparticles and evaluation of their potential application as DNA carrier. J Biomater Sci Polym Ed. 2005;1:43-56.
3. Douglas KL, Piccirillo CA, Tabrizian M. Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles. J Control Release. 2006;115:354-361.
4. Hollins AJ, Benboubetra M, Omidi Y, et al. Evaluation of generation 2 and 3 poly (propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor. Pharm Res. 2004;21:458-466.
5. Silva CM, António J, Ribeiro A, Figueiredo M, Ferreira D, Veiga F. Microencapsulation of hemoglobin in chitosan-coated alginate microspheres prepared by emulsification/internal gelation. AAPS J. 2006;7:E903-E913.
6. Gazori T, Khoshayand MR, Azizi E, Yazdizade P, Nomani A, Haririan I. Evaluation of alginate/chitosan nanoparticles as antisense delivery vector: Formulation, optimization and in vitro characterization. CarbohydratePolymers. 2009;77:599-606.
7. Riaz AA, Bodmeier R. Preparation of performed porous PLGA microparticles and antisense oligonucleotides loading. Eur J Pharm Biopharm. 2009;71:264-270.
8. Liu X, Howard KA, Donga M, et al. The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials. 2007;28:1280-1288.
9. Khalid MN, Agnely F, Yagoubi N, Grossiord JL, Couarraze G. Water state characterization, swelling behavior, thermal and mechanical properties of chitosan based networks. Eur J Pharm Sci. 2002;15: 425-432.
10. Farahani TD, Farahani EV, Mirzadeh H. Swelling behaviour of alginate-n, o carboxymethyl chitosan gel beads coated by chitosan. Iranian Polymer J. 2006;15:405-415.
11. Boonsongrit Y, Mitrevej A, Muller BW. Chitosan drug binding by ionic interaction. Eur J Pharm Biopharm. 2006;62:267-274.
12. Hamidi M, Azadi A, Rafiei P. Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev. 2008;60:1638-1649.
13. Borges O, Cordeiro-da-Silva A, Romeijn SG, et al. Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination. J Control Release. 2006;114;348-358.
14. Ferreira MG, Tillman L, Hardee G, Bodmeier R. Characterization of complexes of an antisense oligonucleotide with protamine and poly- L-lysine salts. J Control Release. 2001;73:381-390.
15. Bildestein L, Hillaireau H, Desmaele D, Leptre-Mouelhi S, Dubernet C, Couvreur P. Freeze-drying of squalenoylated nucleoside analogue nanoparticles. Int J Pharm. 2009;381:140-145.
16. Pozo Rodriguez A, Solinis MA, Gascon AR, Pedraz JL. Short and long term stability of lyophilized solid lipid nanoparticles for gene therapy. Eur J Pharm Biopharm. 2009;71:181-189.
17. Guliyeva U, Oner F, Ozsoy S, Haziroglu R. Chitosan microparticles containing plasmid DNA as potential oral gene delivery system. Eur J Pharm Biopharm. 2006;62:17-25.