An example of the clinical selectivity of regadenoson for the A2a adenosine receptor

American Heart Hospital Journal

Volumn 7, Issue 2, 2009, Pages 118-121

  Miyamoto, Michael I ^a,b   Clarke, Kyle A ^a   Thomas, Gregory S ^a,c   Belardinelli, Luiz ^d  

^a Mission Internal Medical Group   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Gilead Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; REGADENOSON; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; DIAGNOSTIC AGENT; PHARMACOLOGICAL BIOMARKER; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; VASODILATOR AGENT;

AGED; ARTICLE; CASE REPORT; COMPLETE HEART BLOCK; DRUG SELECTIVITY; ELECTROCARDIOGRAPHY; GATED SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; MALE; MYOCARDIAL PERFUSION IMAGING; P WAVE; PAROXYSMAL ATRIAL FIBRILLATION; PHARMACOLOGIC STRESS TESTING; PRESYNCOPE; PRIORITY JOURNAL; QRS COMPLEX; SECOND DEGREE ATRIOVENTRICULAR BLOCK; SINUS RHYTHM; ST SEGMENT DEPRESSION; CARDIAC GATED IMAGING; DRUG EFFECT; EXERCISE TEST;

ADENOSINE; ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; AGED; BIOMARKERS, PHARMACOLOGICAL; CARDIAC-GATED SINGLE-PHOTON EMISSION COMPUTER-ASSISTED TOMOGRAPHY; EXERCISE TEST; HUMANS; MALE; MYOCARDIAL PERFUSION IMAGING; PURINES; PYRAZOLES; RECEPTOR, ADENOSINE A2A; VASODILATOR AGENTS;

EID: 79952115870     PISSN: 15419215     EISSN: 17517168     Source Type: Journal    
DOI: 10.15420/ahhj.2009.7.2.118     Document Type: Article

References (4)

1. Cerqueira MD, Nguyen P, Staehr P, et al. on behalf of the ADVANCE-MPI Trial Investigators, Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2a agonist regadenoson versus adenosine in myocardial perfusion imaging, J Am Coll Cardiol Img, 2008;1:307-16
2. Belardinelli L, Shryock JC, Snowdy S, et al. The A2a adenosine receptor mediates coronary vasodilation, J Pharmacol Exp Ther, 1998;284:1066-73
3. Gao Z, Li X, Baker SP, et al. Novel short-acting A2a adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2a agonists, J Pharmacol Exp Ther, 2001;298(1):209-18
4. Lexiscan prescribing information handbook, Lexiscan (regadenoson) prescribing package insert, Deerfield, IL: Astellas Pharma; January 2009