Do the radiographic features of joint destruction in tophaceous gout imply a different pathophysiology to that of rheumatoid and psoriatic arthritis?

Clinical Rheumatology

Volumn 29, Issue 10, 2010, Pages 1181-1183

  Arendse, Regan ^a,b   Gcelu, Ayanda ^a   Scott, Christiaan ^a   Beighton, Peter ^b   Kalla, Asgar ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ARTHROGRAPHY; ARTICLE; GOUT; HUMAN; PSORIATIC ARTHRITIS; RADIOGRAPHY; RHEUMATOID ARTHRITIS;

ARTHRITIS, PSORIATIC; ARTHRITIS, RHEUMATOID; ARTHROGRAPHY; GOUT; HUMANS;

EID: 79952112299     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-010-1521-4     Document Type: Article

References (5)

1. Belt EA, Kaarela K, Kauppi MJ, Savolainen HA, Kautiainen HJ, Lehto MUK (1999) Assessment of mutilans-like hand deformities in chronic inflammatory joint diseases. A radiographic study of 52 patients. Ann Rheum Dis 58:250-252
2. Dalbeth N, Clark B, Gregory K, Gamble G, Sheehan T, Doyle A, McQueen FM (2009) Mechanisms of bone erosion in gout: a quantitative analysis using plain radiography and computed tomography. Ann Rheum Dis 68:1290-1295
3. Dalbeth N, Smith T, Nicolson B, Clark B, Callon K, Naot D, Haskard DO, McQueen FM, Reid IR, Cornish J (2008) Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells. Arthritis Rheum 58(6):1854-1865
4. Bouchard L, de Médicis R, Lussier A, Naccache PH, Poubelle PE (2002) Inflammatory microcrystals alter the functional phenotype of human osteoblast-like cells in vitro: synergism with IL-1 to overexpress cyclooxygenase-2. J Immunol 168 (10):5310-5317
5. Webb R, Jeffries M, Sawalha AH (2009) Uric acid directly promotes human T-cell activation. Am J Med Sci 337(1):23-27