Calcium hydroxide promotes cementogenesis and induces cementoblastic differentiation of mesenchymal periodontal ligament cells in a CEMP1- and ERK-dependent manner

Calcified Tissue International

Volumn 87, Issue 2, 2010, Pages 144-157

  Paula Silva, Francisco Wanderley Garcia ^a,b   Ghosh, Abhijit ^a   Arzate, Higinio ^c   Kapila, Sunil ^a   Da Silva, Léa Assed Bezerra ^b   Kapila, Yvonne Lorraine ^a  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Calcium hydroxide; Cementogenesis; Cementum protein 1; Periodontal ligament cell; STRO 1 cell surface marker

Indexed keywords

BONE SIALOPROTEIN; CALCIUM HYDROXIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; TRANSCRIPTION FACTOR RUNX2;

ANIMAL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CEMENTUM; CYTOLOGY; DOG; DRUG EFFECT; GENETICS; HUMAN; MESODERM; METABOLISM; PERIODONTAL LIGAMENT; PHYSIOLOGY; REGENERATION; TOOTH DEVELOPMENT;

ANIMALS; CALCIUM HYDROXIDE; CELL DIFFERENTIATION; CELLS, CULTURED; CEMENTOGENESIS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DENTAL CEMENTUM; DOGS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTEGRIN-BINDING SIALOPROTEIN; MESODERM; MODELS, ANIMAL; PERIODONTAL LIGAMENT; PROTEINS; REGENERATION; RNA, MESSENGER;

EID: 79952111282     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-010-9368-x     Document Type: Article

References (42)

1. Nanci A, Bosshardt DD (2006) Structure of periodontal tissues in health and disease. Periodontol 2000 40:11-28
2. Bosshardt DD (2005) Are cementoblasts a subpopulation of osteoblasts or a unique phenotype? J Dent Res 84:390-406
3. Seo B-M, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang C-Y (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364:149-155
4. Chen SC, Marino V, Gronthos S, Bartold PM (2006) Location of putative stem cells in human periodontal ligament. J Periodont Res 41:547-553
5. Nagatomo K, Komaki M, Sekiya I, Sakaguchi Y, Oda S, Muneta T, Ishikawa I (2006) Stem cell properties of human periodontal ligament cells. J Periodont Res 41:303-310
6. Gay IC, Chen S, MacDougall M (2007) Isolation and characterization of multipotent human periodontal ligament stem cells. Orthod Craniofacial Res 10:149-160
7. Jo Y-Y, Lee H-J, Kook S-Y, Choung H-W, Park J-Y, Chung J-H, Choung Y-H, Kim E-S, Yang H-C, Choung P-H (2007) Isolation and characterization of postnatal stem cells from human dental tissues. Tissue Eng 13:767-773
8. Fujii S, Maeda H, Wada N, Tomokiyo A, Saito M, Akamine A (2008) Investigating a clonal human periodontal ligament progenitor/stem cell line in vitro and in vivo. J Cell Physiol 215:743-749
9. Lin N-H, Menicanin D, Mrozik K, Gronthos S, Bartold PM (2008) Putative stem cells in regenerating human periodontium. J Periodontol Res 43:514-523
10. Xu J, Wang W, Kapila Y, Lotz J, Kapila S (2009) Multiple differentiation PTPLA/CAPacity of STRO-1?/CD146? PDL mesenchymal progenitor cells. Stem Cells Dev 18:487-496
11. Kémoun P, Laurencin-Dalicieux S, Rue J, Vaysse F, Roméas A, Arzate H, Conte-Auriol F, Farges JC, Salles JP, Brunel G (2007) Localization of STRO-1, BMP-2/-3/-7, BMP receptors and phosphorylated Smad-1 during the formation of mouse periodontium. Tissue Cell 39:257-266
12. Kémoun P, Laurencin-Dalicieux S, Rue J, Farges J-C, Gennero I, Conte-Auriol F, Briand-Mesange F, Gadelorge M, Arzate H, Narayanan S, Brunel G, Salles J-P (2007) Human dental follicle cells acquire cementoblast features under stimulation by BMP-2/-7 and enamel matrix derivatives (EMD) in vitro. Cell Tissue Res 329:283-294
13. Márton IJ, Kiss C (2000) Protective and destructive immune reactions in apical periodontitis. Oral Microbiol Immunol 15:139-150
14. Saygin NE, Giannobile WV, Sommerman MJ (2000) Molecular and cell biology of cementum. Periodontol 2000 24:73-98
15. Grzesik WJ, Narayanan AS (2002) Cementum and periodontal wound healing and regeneration. Crit Rev Oral Biol Med 13:474-484
16. Foster BL, Sommerman MJ (2005) Regenerating the periodontium: Is there a magic formula? Orthod Craniofacial Res 8:285-291
17. Gonçalves PF, Sallum EA, Casati MZ, Toledo S, Nociti FH Jr (2005) Dental cementum reviewed: Development, structure, composition, regeneration and potential functions. Braz J Oral Sci 4:651-658
18. Álvarez-Pérez MA, Narayanan S, Zeichner-David M, Rodríguez-Carmona B, Arzate H (2006) Molecular cloning, expression and immunolocalization of a novel human cementum-derived protein (CP-23). Bone 38:409-419
19. Arzate H, Jiménez-García LF, A ́ lvarez-Perez MA, Landa A, Bar-Kana I, Pitaru S (2002) Immunolocalization of a human cementoblastoma-conditioned medium-derived protein. J Dent Res 81:541-546
20. Kitagawa M, Tahara H, Kitagawa S, Oka H, Kudo Y, Sato S, Ogawa I, Miyaichi M, Takata T (2006) Characterization of established cementoblast-like cell lines from human cementumlining cells in vitro and in vivo. Bone 39:1035-1042
21. Fava LR, Saunders WP (1999) Calcium hydroxide pastes: Classification and clinical indications. Int Endod J 32:257-282
22. Zayzafoon M, Fulzele K, McDonald JM (2005) Calmodulin and calmodulin-dependent kinase IIa regulate osteoblast differentiation by controlling c-fos expression. J Biol Chem 280:7049-7059
23. Zayzafoon M (2006) Calcium/calmodulin signaling controls osteoblast growth and differentiation. J Cell Biochem 97:56-70
24. Leonardo MR, Silva LA, Leonardo RT, Utrilla LS, Assed S (1993) Histological evaluation of therapy using a calcium hydroxide dressing for teeth with incompletely formed apices and periapical lesions. J Endod 19:348-352
25. Leonardo MR, Hernandez ME, Silva LA, Tanomaru-Filho M (2006) Effect of a calcium hydroxide-based root canal dressing on periapical repair in dogs: A histological study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:680-685
26. Paula-Silva FWG, Hassan B, Silva LAB, Leonardo MR, Wu M-K (2009) Outcome of root canal treatment in dogs determined by periapical radiography and cone-beam computed tomography scans. J Endod 35:723-726
27. Kapila YL, Kapila S, Johnson PW (1996) Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells. Matrix Biol 15:251-261
28. Paula-Silva FWG, Ghosh A, Silva LAB, Kapila YL (2009) TNFa induces an odontoblastic phenotype in dental pulp cells. J Dent Research 88:339-344
29. Kapila YL, Niu J, Johnson PW (1997) The high affinity heparinbinding domain and the V region of fibronectin mediate invasion of human oral squamous cell carcinoma cells in vitro. J Biol Chem 272:18932-18938
30. 2+ influx regulates growth plate chondrocyte maturation and apoptosis. J Biol Chem 278:3762-3769
31. Oliveira PT, Zalzal SF, Beloti MM, Rosa AL, Nanci A (2007) Enhancement of in vitro osteogenesis on titanium by chemically produced nanotopography. J Biomed Mater Res A 80:554-564
32. A ́ lvarez-Pérez MA, Pitaru S, A ́ lvarez-Fregoso O, Reyes-Gasga J, Arzate H (2003) Anti-cementoblastoma-derived protein antibody partially inhibits mineralization on a cementoblastic cell line. J Struct Biol 143:1-13
33. Carmona-Rodríguez B, A ́ lvarez-Pérez MA, Narayanan S, Zeichner-David M, Reyes-Gasga J, Molina-Guarneros J, García- Hernández AL, Suárez-Franco JL, Chavarría IG, Villareal-Ramírez E, Arzate H (2007) Human cementum protein 1 induces expression of bone and cementum proteins by human gingival fibroblasts. Biochem Biophys Res Commun 358:763-769
34. Yang ZH, Zhang XJ, Dang NN, Ma ZF, Xu L, Wu JJ, Sun Y-J, Duan Y-Z, Lin Z, Jin Y (2009) Apical tooth germ cell-conditioned medium enhances the differentiation of periodontal ligament stem cells into cementum/periodontal ligament-like tissues. J Periodontal Res 44:199-210
35. Arzate H, Olson SW, Page RC, Gown AM, Narayanan AS (1992) Production of a monoclonal antibody to an attachment protein derived from human cementum. FASEB J 11:2990-2995
36. BarKana I, Narayanan AS, Grosskop A, Savion N, Pitaru S (2000) Cementum attachment protein enriches putative cementoblastic populations on root surfaces in vitro. J Dent Res 79: 1482-1488
37. Kajiya M, Shiba H, Fujita T, Ouhara K, Takeda K, Mizuno N, Kawaguchi H, Kitagawa M, Takata T, Tsuji K, Kurihara H (2008) Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts. J Biol Chem 283:16259-16267
38. Chuderland D, Marmor G, Shainskaya A, Seger R (2008) Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases. J Biol Chem 283: 11176-11188
39. Liu HW, Yacobi R, Savion N, Narayanan AS, Pitaru S (1997) A collagenous cementum-derived attachment protein is a marker for progenitor of the mineralized tissue-forming cell lineage of the periodontal ligament. J Bone Miner Res 12:1691-1699
40. Hayami T, Zhang Q, Kapila Y, Kapila S (2007) Dexamethasone's enhancement of osteoblastic markers in human periodontal ligament cells is associated with inhibition of collagenase expression. Bone 40:93-104
41. Villarreal-Ramírez E, Moreno A, Mas-Oliva J, Chávez-Pacheco JL, Narayanan AS, Gil-Chavarría I, Zeichner-David M, Arzate H (2009) Characterization of recombinant human cementum protein 1 (rhCEMP1): Primary role in biomineralization. Biochem Biophys Res Commun 384:49-54
42. Schild C, Beyeler M, Lang NP, Trueb B (2009) Cementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth. Int J Mol Med 23:293-296