Is fibrinogen the answer to coagulopathy after massive transfusions?

Critical Care

Volumn 14, Issue 3, 2010, Pages

  Tisherman, Samuel A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; FRESH FROZEN PLASMA;

BLEEDING; BLOOD CLOTTING DISORDER; CRYOPRECIPITATE; ERYTHROCYTE; HEMOSTASIS; HUMAN; MORBIDITY; MORTALITY; NOTE; PRIORITY JOURNAL; ANIMAL MODEL; BLOOD TRANSFUSION; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG EFFECT; TREATMENT OUTCOME;

BLOOD TRANSFUSION; DISSEMINATED INTRAVASCULAR COAGULATION; FIBRINOGEN; HEMOSTASIS; HUMANS; MODELS, ANIMAL; TREATMENT OUTCOME;

EID: 79952109822     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc9000     Document Type: Note

References (13)

1. Grottke O, Braunschweig T, Henzler D, Coburn M, Tolba R, Rossaint R. Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury. Crit Care 2010, 14:R62. 10.1186/cc8960, 20398253.
2. Watson GA, Sperry JL, Rosengart MR, Minei JP, Harbrecht BG, Moore EE, Cuschieri J, Maier RV, Billiar TR, Peitzman AB, . Inflammation and Host Response to Injury Investigators Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma 2009, 67:221-227. 10.1097/TA.0b013e3181ad5957, 19667872, Inflammation and Host Response to Injury Investigators.
3. Malone DL, Dunne J, Tracy JK, Putnam AT, Scalea TM, Napolitano LM. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 2003, 54:898-905. 10.1097/01.TA.0000060261.10597.5C, 12777902.
4. Sarani B, Dunkman WJ, Dean L, Sonnad S, Rohrbach JI, Gracias VH. Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med 2008, 36:1114-1118. 10.1097/CCM.0b013e318168f89d, 18379235.
5. Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma 2008, 64(2 Suppl):S79-85. 10.1097/TA.0b013e318160a57b, 18376176.
6. Fries D, Krismer A, Klingler A, Streif W, Klima G, Wenzel V, Haas T, Innerhofer P. Effect of fibrinogen on reversal of dilutional coagulopathy: a porcine model. Br J Anaesth 2005, 95:172-177. 10.1093/bja/aei160, 15923269.
7. Kreuz W, Meili E, Peter-Salonen K, Dobrkovsk A, Devay J, Haertel S, Krzensk U, Egbring R. Pharmacokinetic properties of a pasteurised fibrinogen concentrate. Transfus Apher Sci 2005, 32:239-246.
8. Fenger-Eriksen C, Lindberg-Larsen M, Christensen AQ, Ingerslev J, Sorensen B. Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations. Br J Anaesth 2008, 101:769-773. 10.1093/bja/aen270, 18818192.
9. Karlsson M, Ternstrom L, Hyllner M, Baghaei F, Flinck A, Skrtic S, Jeppsson A. Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. Thromb Haemost 2009, 102:137-144.
10. Fenger-Eriksen C, Jensen TM, Kristensen BS, Jensen KM, Tonnesen E, Ingerslev J, Sorensen B. Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost 2009, 7:795-802. 10.1111/j.1538-7836.2009.03331.x, 19320829.
11. Mittermayr M, Streif W, Haas T, Fries D, Velik-Salchner C, Klingler A, Oswald E, Bach C, Schnapka-Koepf M, Innerhofer P. Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration. Anesth Analg 2007, 105:905-917. 10.1213/01.ane.0000280481.18570.27, 17898365.
12. Kheirabadi BS, Crissey JM, Deguzman R, Holcomb JB. In vivo bleeding time and in vitro thrombelastography measurements are better indicators of dilutional hypothermic coagulopathy than prothrombin time. J Trauma 2007, 62:1352-1361. 10.1097/TA.0b013e318047b805, 17563647.
13. Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, Perkins JG, Holcomb JB. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma 2008, 64:S64-S68. 10.1097/TA.0b013e318160772d, 18376174.