Attenuated hypocholesterolemia following severe trauma signals risk for late ventilator-associated pneumonia, ventilator dependency, and death: A retrospective study of consecutive patients

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Dunham, C Michael ^a   Chirichella, Thomas J ^a  

^a ST ELIZABETH HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CHOLESTEROL;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ARTICLE; ARTIFICIAL VENTILATION; BRAIN INJURY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DEATH; ENDOTRACHEAL INTUBATION; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; HYPOCHOLESTEROLEMIA; HYPOXEMIA; INJURY SCALE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; RETROSPECTIVE STUDY; SEX DIFFERENCE; SHOCK; SMOKING; THORAX INJURY; TREATMENT DURATION; VENTILATOR ASSOCIATED PNEUMONIA; BLOOD; INJURY; LENGTH OF STAY; MORTALITY; RISK FACTOR; VENTILATOR;

CHOLESTEROL; ERYTHROCYTE TRANSFUSION; HUMANS; INJURY SEVERITY SCORE; INTUBATION, INTRATRACHEAL; LENGTH OF STAY; PNEUMONIA, VENTILATOR-ASSOCIATED; RETROSPECTIVE STUDIES; RISK FACTORS; SHOCK; THORACIC INJURIES; VENTILATOR WEANING; VENTILATORS, MECHANICAL; WOUNDS AND INJURIES;

EID: 79952105516     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-42     Document Type: Article

References (38)

1. Ventilator-associated pneumonia, like real estate: location really matters. MJ Eckert KA Davis RL Reed TJ Esposito JM Santaniello S Poulakidas, et al. J Trauma 2006 60 104 110 10.1097/01.ta.0000197376.98296.7c 16456443
2. A formula for prediction of posttraumatic pneumonia based on early anatomic and physiologic parameters. MA Croce EA Tolley TC Fabian, J Trauma 2003 54 724 729 10.1097/01.TA.0000054643.54218.C5 12707535
3. Is ventilator-associated pneumonia in trauma patients an epiphenomenon or a cause of death? LJ Magnotti MA Croce TC Fabian, Surg Infect (Larchmt) 2004 5 237 242 10.1089/sur.2004.5.237 15684794 (Pubitemid 39462166)
4. Ventilator-associated pneumonia in severe traumatic brain injury. DA Zygun DJ Zuege PJ Boiteau KB Laupland EA Henderson JB Kortbeek, et al. Neurocrit Care 2006 5 108 114 10.1385/NCC:5:2:108 17099256 (Pubitemid 44729635)
5. The effect of ventilator-associated pneumonia on the prognosis of head trauma patients. H Kallel H Chelly M Bahloul H Ksibi H Dammak A Chaari, et al. J Trauma 2005 59 705 710 16361916 (Pubitemid 43014939)
6. Efficacy of a pneumonia prevention protocol in the reduction of ventilator-associated pneumonia in trauma patients. T Lansford M Moncure E Carlton R Endress N Shik K Udobi, et al. Surg Infect (Larchmt) 2007 8 505 510 10.1089/sur.2006.001 17999583 (Pubitemid 350114695)
7. Risk and prognostic factors of ventilator-associated pneumonia in trauma patients. M Cavalcanti M Ferrer R Ferrer R Morforte A Garnacho A Torres, Crit Care Med 2006 34 1067 1072 10.1097/01.CCM.0000206471.44161.A0 16484918
8. Early IL-6 plasma concentrations correlate with severity of brain injury and pneumonia in brain-injured patients. C Woiciechowsky B Schoning J Cobanov WR Lanksch HD Volk WD Docke, J Trauma 2002 52 339 345 10.1097/00005373-200202000- 00021 11834998 (Pubitemid 34183803)
9. Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia. MJ Cohen N Bir P Rahn R Dotson K Brohi BB Chesebro, et al. J Trauma 2009 67 1176 1181 10.1097/TA.0b013e3181c1c1bc 20009664
10. Inflammatory markers: superior predictors of adverse outcome in blunt trauma patients? CM Dunham D Frankenfield H Belzberg CE Wiles B Cushing Z Grant, Crit Care Med 1994 22 667 672 10.1097/00003246-199404000-00024 8143476 (Pubitemid 24121569)
11. Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection. CM Dunham MH Fealk WE Sever III, Crit Care 2003 7 145 R153 10.1186/cc2382 14624689
12. Effects of antiepileptic drugs on lipids, homocysteine, and C-reactive protein. S Mintzer CT Skidmore CJ Abidin MC Morales I Chervoneva DM Capuzzi, et al. Ann Neurol 2009 65 448 456 10.1002/ana.21615 19296463
13. A mechanistic approach to antiepileptic drug interactions. GD Anderson, Ann Pharmacother 1998 32 554 563 10.1345/aph.17332 9606477 (Pubitemid 28232761)
14. Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use: the Minnesota Heart Survey, 1980-1982 to 2000-2002. DK Arnett DR Jacobs Jr RV Luepker H Blackburn C Armstrong SA Claas, Circulation 2005 112 3884 3891 10.1161/CIRCULATIONAHA.105.549857 16344385 (Pubitemid 43739486)
15. Changes in cholesterol and its precursors during the first days after major trauma. B Bakalar R Hyspler J Pachl Z Zadak, Wien Klin Wochenschr 2003 115 775 779 10.1007/BF03040502 14743581 (Pubitemid 38101156)
16. Necrotizing soft tissue infections. Risk factors for mortality and strategies for management. DC Elliott JA Kufera RA Myers, Ann Surg 1996 224 672 683 10.1097/00000658-199611000-00011 8916882 (Pubitemid 26384890)
17. [Disturbances of lipoprotein and fatty acid metabolism in patients with heavy injuries (author's transl)]. G Wolfram J Eckart N Zollner, Klin Wochenschr 1980 58 1327 1337 10.1007/BF01477730 6782330 (Pubitemid 11253328)
18. Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients. BR Gordon TS Parker DM Levine SD Saal JC Wang BJ Sloan, et al. Crit Care Med 2001 29 1563 1568 10.1097/00003246-200108000- 00011 11505128 (Pubitemid 32762337)
19. Cytochrome P450 s and cholesterol homeostasis. IA Pikuleva, Pharmacol Ther 2006 112 761 773 10.1016/j.pharmthera.2006.05.014 16872679
20. Mini-series: II. clinical aspects. clinically relevant CYP450-mediated drug interactions in the ICU. I Spriet W Meersseman J de Hoon S von Winckelmann A Wilmer L Willems, Intensive Care Med 2009 35 603 612 10.1007/s00134-008-1383-2 19132344
21. Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis. JY Chien JS Jerng CJ Yu PC Yang, Crit Care Med 2005 33 1688 1693 10.1097/01.CCM.0000171183.79525.6B 16096442
22. Pathophysiologic correlates of hypocholesterolemia in critically ill surgical patients. I Giovannini G Boldrini C Chiarla F Giuliante M Vellone G Nuzzo, Intensive Care Med 1999 25 748 751 10.1007/s001340050940 10470581 (Pubitemid 29376131)
23. Lipids, lipoproteins, and apoproteins in serum during infection. C Alvarez A Ramos, Clin Chem 1986 32 142 145 3940695 (Pubitemid 17033795)
24. Prognostic significance of low serum cholesterol after cardiothoracic surgery. A Stachon A Boning H Weisser A Laczkovics G Skipka M Krieg, Clin Chem 2000 46 1114 1120 10926891 (Pubitemid 30643313)
25. Cholesterol and serum albumin levels as predictors of cross infection, death, and length of hospital stay. M Delgado-Rodriguez M Medina-Cuadros A Gomez-Ortega G Martinez-Gallego M Mariscal-Ortiz MA Martinez-Gonzalez, et al. Arch Surg 2002 137 805 812 10.1001/archsurg.137.7.805 12093337 (Pubitemid 34743171)
26. Cholesterol and serum albumin as risk factors for death in patients undergoing general surgery. S Palma A Cosano M Mariscal G Martinez-Gallego M Medina-Cuadros M Delgado-Rodriguez, Br J Surg 2007 94 369 375 10.1002/bjs.5626 17279492 (Pubitemid 46423857)
27. Hypocholesterolemia and risk of death in the critically ill surgical patient. D Gui PL Spada A De Gaetano F Pacelli, Intensive Care Med 1996 22 790 794 10.1007/BF01709522 8880248 (Pubitemid 26355547)
28. Systemic inflammation after trauma. A Lenz GA Franklin WG Cheadle, Injury 2007 38 1336 1345 10.1016/j.injury.2007.10.003 18048040 (Pubitemid 350192404)
29. Immune responses to inflammation and trauma: a physical training model. RJ Shephard PN Shek, Can J Physiol Pharmacol 1998 76 469 472 10.1139/cjpp-76-5-469 9839070 (Pubitemid 28549619)
30. The inflammatory response to surgery and trauma. BA Kohl CS Deutschman, Curr Opin Crit Care 2006 12 325 332 10.1097/01.ccx.0000235210.85073.fc 16810043 (Pubitemid 44078145)
31. Release of anti-inflammatory mediators after mechanical trauma correlates with severity of injury and clinical outcome. W Ertel M Keel M Bonaccio U Steckholzer H Gallati JS Kenney, et al. J Trauma 1995 39 879 885 10.1097/00005373-199511000-00011 7474003
32. Inflammatory serum markers in patients with multiple trauma. Can they predict outcome? PV Giannoudis F Hildebrand HC Pape, J Bone Joint Surg Br 2004 86 313 323 10.1302/0301-620X.86B3.15035 15125116 (Pubitemid 38559481)
33. Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients. M Meisner H Adina J Schmidt, Crit Care 2006 10 1 10.1186/cc3910 16356205
34. Relationship of systemic inflammatory response syndrome to organ dysfunction, length of stay, and mortality in critical surgical illness: effect of intensive care unit resuscitation. M Talmor L Hydo PS Barie, Arch Surg 1999 134 81 87 10.1001/archsurg.134.1.81 9927137 (Pubitemid 29047222)
35. National nosocomial infection surveillance system: from benchmark to bedside in trauma patients. PR Miller JC Johnson T Karchmer JJ Hoth JW Meredith MC Chang, J Trauma 2006 60 98 103 10.1097/01.ta.0000196379.74305.e4 16456442
36. Diagnosis of ventilator-associated pneumonia: a systematic review of the literature. A Rea-Neto NC Youssef F Tuche F Brunkhorst VM Ranieri K Reinhart, et al. Crit Care 2008 12 56 10.1186/cc6877 18426596
37. Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: diagnosis and treatment. J Muscedere P Dodek S Keenan R Fowler D Cook VAP Guidelines Committee and the Canadian Critical Care Trials Group, J Crit Care 2008 23 138 147 10.1016/j.jcrc.2007.12.008 18359431 (Pubitemid 351400356)
38. Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: patient-oriented research core - standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (VAP) in the trauma patient. JP Minei AB Nathens M West BG Harbrecht EE Moore MB Shapiro, et al. J Trauma 2006 60 1106 1113 10.1097/01.ta.0000220424.34835.f1 16688078 (Pubitemid 43778650)