Identification of phospholipids in human meibum by nano-electrospray ionisation tandem mass spectrometry

Experimental Eye Research

Volumn 92, Issue 3, 2011, Pages 238-240

  Saville, Jennifer T ^a   Zhao, Zhenjun ^b,c   Willcox, Mark D P ^b,c   Ariyavidana, Manjula A ^b   Blanksby, Stephen J ^a   Mitchell, Todd W ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b BRIEN HOLDEN VISION INSTITUTE   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; PHOSPHOLIPID;

ADULT; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; LACRIMAL FLUID; MALE; MEIBOMIAN GLAND; NANO ELECTROSPRAY IONISATION TANDEM MASS SPECTROMETRY; PRIORITY JOURNAL;

ADULT; BODILY SECRETIONS; FEMALE; HUMANS; MALE; MEIBOMIAN GLANDS; MIDDLE AGED; PHOSPHOLIPIDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TEARS;

EID: 79952101281     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.12.012     Document Type: Article

References (27)

1. Borchman D., Foulks G.N., et al. Spectroscopic evaluation of human tear lipids. Chem. Phys. Lipids 2007, 147:87-102.
2. Bron, A.M., Tiffany, J.M., 1998. The Meibomian glands and tear film lipids: structure, function and control. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. e. a. Sullivan.
3. Brugger B., Erben G., et al. Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:2339-2344.
4. Butovich I.A. On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids. Invest. Ophthalmol. Vis. Sci. 2008, 49:3779-3789.
5. Butovich I.A. Cholesterol esters as a depot for very long chain fatty acids in human meibum. J. Lipid Res. 2009, 50:501-513.
6. Butovich I.A. The meibomian puzzle: combining pieces together. Prog. Retin. Eye Res. 2009, 28:483-498.
7. Butovich I.A., Millar T.J., et al. Understanding and analyzing meibomian lipids - a review. Curr. Eye Res. 2008, 33:405-420.
8. Butovich I.A., Uchiyama E., et al. Liquid chromotography-mass spectrometric analysis of lipids present in human meibomian gland secretions. Lipids 2007, 42:765-776.
9. Butovich I.A., Uchiyama E., et al. Lipids of the meibomum: mass-spectrometric analysis and structural elucidation. J. Lipid Res. 2007, 48:2220-2235.
10. Butovich I.A., Wojtowics J.C., et al. Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum. J. Lipid Res. 2009, 50:2471-2485.
11. Byrdwell W.C. Atmospheric pressure chemical ionization mass spectrometry for analysis of lipids. Lipids 2001, 36:327-346.
12. Chen J., Green-Church K.B., et al. Shotgun lipidomic analysis of human meibomian gland secretions with electrospray ionization tandem mass spectrometry. Invest. Ophthalmol. Vis. Sci. 2010, 51:6220-6231.
13. Cole M.J., Enke C.G. Fast atom bombardment tandem mass spectrometry employing ion-molecule reactions for the differentiation of phospholipid classes. J. Am. Soc. Mass Spectrom. 1991, 2:470-475.
14. Deeley J.M., Mitchell T.W., et al. Human lens lipids differ markedly from those of commonly used experimental animals. Biochim. Biophys. Acta 2008, 1781:288-298.
15. Han X., Gross R.W. Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectros. Rev. 2005, 24:367-412.
16. Ismaiel O.A., Halquist M.S., et al. Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations. J. Chromatogr. B 2008, 875:333-343.
17. McCulley J.P., Shine W.E. A compositional based model for the tear film lipid layer. Trans. Am. Ophthalmol. Soc. 1997, 95:79-93.
18. Nichols K.K., Ham B.M., et al. Identification of fatty acids and fatty acid amides in human meibomian gland secretions. Invest. Ophthalmol. Vis. Sci. 2007, 41:34-39.
19. Ohashi Y., Dogru M., et al. Laboratory findings in tear fluid analysis. Clin. Chim. Acta 2006, 369:17-28.
20. Pes O. Ricerche microchimiche sulla secrezione delle ghiandole sebacee palpebrali. Arch. Ottalmol. 1897, 5:82-91.
21. Sack R.A., Tan K.O., et al. Diurnal tear cycle: evidence for a nocturnal inflammatory constitutive tear fluid. Invest. Ophthalmol. Vis. Sci. 1992, 33:626-640.
22. Saville J.T., Zhao Z., et al. Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution. Invest. Ophthalmol. Vis. Sci. 2010, 51:2843-2851.
23. Shine W.E., McCulley J.P. Polar lipids in human meibomian gland secretions. Curr. Eye Res. 2003, 26:89-94.
24. Sirigu P., Shen R.-L., et al. Human meibomain glands: the ultrastructure of acinar cells as viewed by thin section and freeze-fracture transmission electron microscopies. Invest. Ophthalmol. Vis. Sci. 1992, 33:2284-2292.
25. Sullivan B.D., Evans J.E., et al. Complete androgen insensitivity syndrome. Effect on human meibomian gland secretions. Arch. Ophthalmol. 2002, 120:1689-1699.
26. Sullivan B.D., Evans J.E., et al. Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions. Arch. Ophthalmol. 2006, 124:1286-1292.
27. Tiffany J.M. Individual variations in human meibomian lipid composition. Exp. Eye Res. 1978, 27:289-300.