Antidiarrheal activity of methanolic extract of Moringa oleifera lam roots in experimental animal models

International Journal of Pharmaceutical Research

Volumn 2, Issue 2, 2010, Pages 35-39

  Saralaya, Mahesh G ^a   Patel, Paras ^a   Patel, Manish ^a   Roy, Samresh Pal ^b   Patel, Asish N ^b  

^a CKPithawalla Institute Of Pharmaceutical Science and Research   (India)

^b Shree Dhanvantary Pharmacy College   (India)

Author keywords

Intestinal fluid accumulation; Intestinal transit; Moringa oleifera; Radiation diarrhea; Volume of intestinal content

Indexed keywords

ATROPINE; CASTOR OIL; METHANOL; MORINGA OLEIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIARRHEAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; FEMALE; GASTROINTESTINAL SECRETION; INTESTINE FLUID; INTESTINE TRANSIT TIME; LD 50; MALE; NONHUMAN; PHYTOCHEMISTRY; PLANT ROOT; RAT; SOLVENT EXTRACTION;

EID: 79952094056     PISSN: None     EISSN: 09752366     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Chatterjee A, Pakrashi SC. In: The treatise on Indian medicinal plants. Vol. I. New Delhi: Publication and Information Directoratsse, 1991:159.
2. Bodding PO. In: Santhal medicine. Calcutta: Laxmi Janardan Press, 1983:352-353.
3. Kalkunte S, Swamy N, Dizon DS, Brard L. Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro. J Exp Ther Oncol. 2006; 5:287-300.
4. Satyan KS, Swamy N, Dizon DS, Singh R, Granai CO, Brard L. Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation. Gynecol Oncol. 2006; 103:261-270.
5. Dahot MU. Antimicrobial activity of small protein of Moringa oleifera leaves. Journal of Islamic Academy of Sciences 11:1, 27-32, 1998.
6. Gupta M. Mazumder UK, Chakrabarti S. CNS activities of methanolic extract of Moringa oleifera root in mice. Fitoterapia. 70(1999), 244-250.
7. Fauci AS, Bravnwold E, Isselpacker K, Wilson JD, kasper DL, Hauser SL, Longo DL (1993). Harrison's Principles of Internal Medicine. New York, McGraw Hill Company. vol (1): 236-242.
8. Park K (2000).Park's Textbook of preventive and social medicine.Jabalpur, India, M/S Banarsidas Bharat Publishes. pp. 172-175.
9. Hardman JG, Limberd LE (1992) The Pharmacological basis of therapeutics. In: Goodman and Gilman's (Eds), 10thedition, MacGrawHill, New York. pp. 914-931.
10. Kokate CK. Practical Pharmacognosy, 4th edition, Vallabh prakashan, Delhi; 1994, 107-109.
11. Mazumder UK, Gupta M, Chakrabarti S, Pal D. Evaluation of hematological and hepatorenal functions of methanolic extract of Moringa oleifera Lam root treated mice. Indian J Exp Biol. 1999;37:612-614.
12. Awounters, F., Niemegeers, C.J.E., Lenaerts, F.M., Janseen, P.A.J., Delay of castor oil diarhoea in rats; a new way to evaluate inhibitors of prostaglandin biosynthesis. Journal of Pharmacy Pharmacology, 30:41-45, 1978.
13. Robert A., Nezamis, J.E., Lancaster, C., Hanchar, A.J., Klepper, M.S., Enteropooling assay; a test for diarrhea produced by prostaglandins, Prostaglandins, 11:809-828, 1976.
14. Mascolo, N., Izzo, A.A., Avotore, G., Barboto, F., Capasso, F., Nitric oxide and castor oil included diarrhea, Journal of Pharmacology and Experimental therapeutics, 268: 291-292, 1994.
15. Horton, E.W., Main, I.H.M., Thampson, C.J. and Wright, P.M., Effects of orally administered, PGE on gastric secretion and gastrointestinal motility in man, Gut, 9:655-658, 1968.
16. Greenbargena, N.J., Arwanitakis, C. and Hurwitz, A.,: Azarnoff, D.L. (eds), In drug development of gastrointestinal disorders, Chrurchill Livingstone, New-York, pp 155-156, 1978.
17. Pierce, N.F., Carpenter, C.C.J., Elliot, H.Z. and Greenough, W.B., Effects of prostaglandins, theophylline and Cholera exotoxin upon transmucosal water and electrolyte movement in canine jejunum, Gastroenterology, 60: 22-32, 1971.
18. Brown J.A. and Taylor, P., Muscarinic receptor agonists and antagonist. In: Hardman, J.G. Limbird, L.E.(Eds), Goodman and Gilman's The pharmacological Basis of therapeutics 10th Edition, McGraw Hill, New York, pp 115-158, 2000.
19. Izzo, A.A., Mascolo, N., Capasso, R., Germano, M.P., DePasquel, R., Capasso, F., Inhibitory effect ofcannabinoid agonists on gastric emptying in the rat, Arch. of Pharmacology, 360: 221-223, 1999.
20. Galvez, J., Zavzuelo, A., Crespo, M.E., Lorente, M.D., Ocete, M.A. and Jimenez, J., Antidiarrhoeic activity of Euphorbia hirta extract and isolation of an active flavanoid constituent, Planta Medica, 59: 333-336, 1993.
21. th International Symposium on Natural Products Chemistry] 269-277. Harwood Amsterdam.
22. Tripathi, K.D., Essentials of Medical Pharmacology, Jaypee Brothers Medical Publishers (P), New Delhi, pp 775, 1994.
23. Ammon, H.V. and Soergel, K.H., Diarrhea In Berk J.E. (eds): Bockus Gastroenterology, Philadelphia, Saunders, pp, 125-141, 1985.
24. Longana-Otshudi, A. Vercruysse, A. and Foriers, A., Contribution to the ethnobotanical, phytochemical and pharmacological studies of traditionally used medicinal plants in the treatment of dysentery and diarrhea in Lomela area, Democratic Republic of Congo (DRC), J. Ethnopharmacol, 71, 3, 411-23, 2000.
25. Chinmoy K. Bose Possible Role of Moringa oleifera Lam. Root in Epithelial Ovarian Cancer MedGenMed. 2007; 9(1): 26.
26. Guevara AP, Vargas C, Sakurai H, et al. An antitumor promoter from Moringa oleifera Lam. Mutat Res. 1999; 440:181-188.
27. Hsu, R.; Midcap, S., Arbainsyah, M.; de Witte, L. International Course on Economic Botany, National Herbarium Leiden. The Netherlands: Moringa oleifera: medicinal and socio-economic uses. September 2006.
28. The wealth of India, Raw materials Publication and Information Directorate, CSIR, New Delhi, Vol.3, pp 78-84, 1992.