Synthesis, characterization and antimicrobial activity of Benzimidazolyl-Phenothiazine derivatives

International Journal of Pharmaceutical Research

Volumn 2, Issue 2, 2010, Pages 45-50

  Kumar, Sharad ^a   Gupta, V D ^b   Seth, A K ^a   Yadav, Yogesh Chand ^a   Sahoo, Ujjwal ^a   Ghelani, Tejas K ^a   Sen, Ashim Kumar ^a   Dhanya, B ^a  

^a K M SHAH DENTAL COLLEGE AND HOSPITAL   (India)

^b MJRP Universities   (India)

Author keywords

Benzamine; Benzimidazole; Phenothiazines

Indexed keywords

10 (ALPHA 4 BENZIMIDAZOLYL AMINOBENZYL)PHENOTHIAZINE DERIVATIVE; 10 (ALPHA 4 CARBOXYPHENYLAMINOBENZYL)PHENOTHIAZINE DERIVATIVE; 4 AMINOBENZOIC ACID; ALCOHOL; ALDEHYDE; ANTIBIOTIC AGENT; BENZIMIDAZOLYLPHENOTHIAZINE DERIVATIVE; DIPHENYLAMINE; IODINE; N [[2 [4 ((10H PHENOTHIAZIN 10 YL)(PHENYL)B METHYLAMINO)PHENYL] 1H BENZO[D]IMIDAZOL 1 YL](PHENYL)METHYL] 4 CHLOROBENZAMINE; N [[2 [4 ((10H PHENOTHIAZIN 10 YL)(PHENYL)METHYLAMINO)PHENYL] 1H BENZO[D]IMIDAZOL 1 YL](PHENYL)METHYL] 2 CHLOROBENZAMINE; N [[2 [4 ((10H PHENOTHIAZIN 10 YL)(PHENYL)METHYLAMINO)PHENYL] 1H BENZO[D]IMIDAZOL 1 YL](PHENYL)METHYL] 3 CHLOROBENZAMINE; N [[2 [4 ((10H PHENOTHIAZIN 10 YL)(PHENYL)METHYLAMINO)PHENYL] 1H BENZO[D]IMIDAZOL 1 YL](PHENYL)METHYL]BENZAMINE; PHENOTHIAZINE; PHENYLENEDIAMINE; PYRIDINE; SULFUR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DISK DIFFUSION; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; MELTING POINT; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE;

EID: 79952090323     PISSN: None     EISSN: 09752366     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Mosnaim D, Ranade V, Wolf ME, Puente J. Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents. American journal of therapeutics 2006; 13: 261-27.
2. Ehrlich P, Chemotherapeutics scientific principles, methods, and results. Lancet 1913;2: 445-51.
3. Bettencourt M, Amaral L. Enhancement of antibiotic activity against Poly-Drug Resistant Mycobacterium tuberculosis by phenothiazines. International Journal of Antimicrobial Agents 2001; 17:225-8.
4. Amaral L, Kristiansen JE, Lorian V. Synergistic effect of chlorpromazine on the activity of some antibiotics. journal of Antimicrobial Chemotherapy 1992; 30:556-8.
5. Kristiansen JE, Thomsen VF, Maral L. The reversal of antibiotic resistance by phenothiazines. 18th Int. Congr Chemotherapy 1993; 65:510.
6. Gulgun AK, Nurten A. Synthesis and antimicrobial activities of some new benzimidazole derivatives. International Journal of Antimicrobial Agents 2003; 58: 1345-1350.
7. Leonard, A, Jette E.K. Phenothiazines potential management of Creutzfeldt-Jacob disease and its variants, International Journal of Antimicrobial Agents 2001; 18:411-417.
8. Pandey VK, Saxena SK, Joshi N. Bajpai, S.K. Synthesis and antiviral activity of some novel unsubstituted phenothiazines. Indian Journal of Chemistry 2004; 43 (13): 1010-15.
9. Bondi A, Spaulding EH, Smith DE, Dietz CC. Routine method for rapid determination of suspectibility to penicillin and other antibiotics. American Journal of medical sciences 1947; 213:221-225.
10. Jennifer MA. Report of the working party on antibiotic sensitivity testing of the British Society for Antimicrobial chemotherapy, a guide to sensitivity testing. Journal of Antimicrobial Chemotherapy 1991; 27: 1-50.
11. Andrews, JM. Determination of minimum inhibitory concentration. Journal of Antimicrobial Chemotherapy 2001; 48: 5-11.
12. Phair JP, Watanakunakarn C, Bannister T. In vitro Suspectibility of Pseudomonas aeruginosa to carbinicillin and the combination carbinicillin and Gentamicin. American Society for microbiology 1969; 18(3): 303-306.
13. Trerse KL, Bagyalakshmi R, Madhavan HN, Deepa P. In vitro Suspectibility testing by agar dilution method to determine the MIC of Amphotericin- B, Fluconazole and ketoconazole against ocular fungal isolates. Indian Journal of Med. Microbio 2006; 24(4):273-279.
14. Davis W, Stout TR. Disc Plate Method of Microbiological Antibiotic Asay. Appl Environ Microbiol. 1971; 22(4): 666-670.
15. th edition, Nirali Publication. 2006; 111-116.
16. thedition, CBS Publishers and distributors 2005; 289-366.