Distribution of Gb 3 Immunoreactivity in the Mouse Central Nervous System

Toxins

Volumn 2, Issue 8, 2010, Pages 1997-2006

  Obata, Fumiko ^a   Obrig, Tom ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Circumventricular organs (CVO); Ependymal cells; Globotriaosylceramide (Gb 3); Neuron

Indexed keywords

GLOBOTRIAOSYLCERAMIDE; PROTEIN ANTIBODY;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; EPENDYMA CELL; HIPPOCAMPUS; HYPOTHALAMUS; IMMUNOREACTIVITY; MALE; MEDULLA OBLONGATA; MOUSE; NONHUMAN; OLFACTORY BULB; PROTEIN EXPRESSION; THALAMUS;

EID: 79952089001     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins2081997     Document Type: Article

References (24)

1. Bale, J.F.; Brasher, C.; Siegler, R.L. CNS manifestations of the hemolytic-uremic syndrome. Relationship to metabolic alterations and prognosis. Am. J. Dis. Child 1980, 134, 869-872.
2. Brasher, C.; Siegler, R.L. The hemolytic-uremic syndrome. West J. Med. 1981, 134, 193-197.
3. Cimolai, N.; Morrison, B.J.; Carter, J.E. Risk factors for the central nervous system manifestations of gastroenteritis-associated hemolytic-uremic syndrome. Pediatrics 1992, 90, 616-621.
4. Gianantonio, C.A.; Vitacco, M.; Mendilaharzu, F.; Gallo, G.E.; Sojo, E.T. The hemolytic-uremic syndrome. Nephron 1973, 11, 174-192.
5. Hamano, S.; Nakanishi, Y.; Nara, T.; Seki, T.; Ohtani, T.; Oishi, T.; Joh, K.; Oikawa, T.; Muramatsu, Y.; Ogawa, Y.; Akashi, S. Neurological manifestations of hemorrhagic colitis in the outbreak of Escherichia coli O157:H7 infection in Japan. Acta Paediatr. 1993, 82, 454-458.
6. Karmali, M.A.; Petric, M.; Lim, C.; Fleming, P.C.; Arbus, G.S.; Lior, H. The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J. Infect. Dis. 1985, 151, 775-782.
7. Rooney, J.C.; Anderson, R.M.; Hopkins, I.J. Clinical and pathologic aspects of central nervous system involvement in the haemolytic uraemic syndrome. Proc. Aust. Assoc. Neurol. 1971, 8, 67-75.
8. Sheth, K.J.; Sarff, L.D. Hemolytic uremic syndrome associated with Corynebacterium diphtheria infection. Int. J. Pediatr. Nephrol. 1986, 7, 17-20.
9. Tapper, D.; Tarr, P.; Avner, E.; Brandt, J.; Waldhausen, J. Lessons learned in the management of hemolytic uremic syndrome in children. J. Pediatr. Surg. 1995, 30, 158-163.
10. Siegler, R.L. Spectrum of extrarenal involvement in postdiarrheal hemolytic-uremic syndrome. J. Pediatr. 1994, 125, 511-518.
11. Taylor, C.M.; White, R.H.; Winterborn, M.H.; Rowe, B. Haemolytic-uraemic syndrome: Clinical experience of an outbreak in the West Midlands. Br. Med. J. (Clin. Res. Ed.) 1986, 292, 1513-1516.
12. Upadhyaya, K.; Barwick, K.; Fishaut, M.; Kashgarian, M.; Siegel, N.J. The importance of nonrenal involvement in hemolytic-uremic syndrome. Pediatrics 1980, 65, 115-120.
13. Verweyen, H.M.; Karch, H.; Allerberger, F.; Zimmerhackl, L.B. Enterohemorrhagic Escherichia coli (EHEC) in pediatric hemolytic-uremic syndrome: A prospective study in Germany and Austria. Infection 1999, 27, 341-347.
14. Waddell, T.; Cohen, A.; Lingwood, C.A. Induction of verotoxin sensitivity in receptor-deficient cell lines using the receptor glycolipid globotriosylceramide. Proc. Natl. Acad. Sci. USA 1990, 87, 7898-7901.
15. Okuda, T. Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J. Biol. Chem. 2006, 281, 10230-10235.
16. Obata, F.; Tohyama, K.; Bonev, A.D.; Kolling, G.L.; Keepers, T.R.; Gross, L.K.; Nelson, M.T.; Sato, S.; Obrig, T.G. Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons. J. Infect. Dis. 2008, 198, 1398-1406.
17. DiMario, F.J., Jr.; Bronte-Stewart, H.; Sherbotie, J.; Turner, M.E. Lacunar infarction of the basal ganglia as a complication of hemolytic-uremic syndrome. MRI and clinical correlations. Clin. Pediatr. (Phila) 1987, 26, 586-590.
18. Jeong, Y.K.; Kim, I.O.; Kim, W.S.; Hwang, Y.S.; Choi, Y.; Yeon, K.M. Hemolytic uremic syndrome: MR findings of CNS complications. Pediatr. Radiol. 1994, 24, 585-586.
19. Signorini, E.; Lucchi, S.; Mastrangelo, M.; Rapuzzi, S.; Edefonti, A.; Fossali, E. Central nervous system involvement in a child with hemolytic uremic syndrome. Pediatr. Nephrol. 2000, 14, 990-992.
20. Steinborn, M.; Leiz, S.; Rudisser, K.; Griebel, M.; Harder, T.; Hahn, H. CT and MRI in haemolytic uraemic syndrome with central nervous system involvement: Distribution of lesions and prognostic value of imaging findings. Pediatr. Radiol. 2004, 34, 805-810.
21. Fujii, J.; Kinoshita, Y.; Kita, T.; Higure, A.; Takeda, T.; Tanaka, N.; Yoshida, S. Magnetic resonance imaging and histopathological study of brain lesions in rabbits given intravenous verotoxin 2. Infect. Immun. 1996, 64, 5053-5060.
22. Duvernoy, H.M.; Risold, P.-Y. The circumventricular organs: An atlas of comparative anatomy and vascularization. Brain Res. Rev. 2007, 56, 119-147.
23. Abbott, N.J. Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology. Neurochem. Int. 2004, 45, 545-552.
24. Kolling, G.L.; Obata, F.; Gross, L.K.; Obrig, T.G. Immunohistologic techniques for detecting the glycolipid Gb(3) in the mouse kidney and nervous system. Histochem. Cell Biol. 2008, 130, 157-164.