Downregulation of runt-related transcription factor 3 associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland

Cancer Science

Volumn 102, Issue 2, 2011, Pages 492-497

  Sasahira, Tomonori ^a   Kurihara, Miyako ^a   Yamamoto, Kazuhiko ^a   Bhawal, Ujjal K ^a   Kirita, Tadaaki ^a   Kuniyasu, Hiroki ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; TRANSCRIPTION FACTOR RUNX3;

ADENOID CYSTIC CARCINOMA; ADENOSQUAMOUS CARCINOMA; ADULT; ARTICLE; CANCER LOCALIZATION; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DNA METHYLATION; FEMALE; GENE DELETION; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MALE; MULTICENTER STUDY; NUCLEOTIDE SEQUENCE; PLEOMORPHIC ADENOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN METHYLATION; RECEPTOR DOWN REGULATION; SALIVARY GLAND; SALIVARY GLAND ADENOID CYSTIC CARCINOMA; SALIVARY GLAND CANCER; SALIVARY GLAND CARCINOMA; SALIVARY GLAND MUCOEPIDERMOID CARCINOMA; SALIVARY GLAND PLEOMORPHIC ADENOMA; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ADENOMA, PLEOMORPHIC; CARCINOMA, ADENOID CYSTIC; CARCINOMA, MUCOEPIDERMOID; CORE BINDING FACTOR ALPHA 3 SUBUNIT; DNA METHYLATION; DOWN-REGULATION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LASERS; MICRODISSECTION; NEOPLASM STAGING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SALIVARY GLAND NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 79952085797     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2010.01787.x     Document Type: Article

References (37)

1. Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB. Radiotherapy aloneor combined with surgery for salivary gland carcinoma. Cancer 2005; 103(12): 2544-50.
2. Milano A, Longo F, Basile M, Iaffaioli RV, Caponigro F. Recent advances in the treatment of salivary gland cancers: emphasis on molecular targeted therapy. Oral Oncol 2007; 43(8): 729-34.
3. Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N. Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol 2005; 41(7): 716-22.
4. Hanai J, Chen LF, Kanno T et al. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline calpha promoter. J Biol Chem 1999; 274(44): 31577-82.
5. Zaidi SK, Sullivan AJ, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci U S A 2002; 99(12): 8048-53.
6. Li QL, Ito K, Sakakura C et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 2002; 109(1): 113-24.
7. Goel A, Arnold CN, Tassone P et al. Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. Int J Cancer 2004; 112(5): 754-9.
8. Mori T, Nomoto S, Koshikawa K et al. Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma. Liver Int 2005; 25(2): 380-8.
9. Yanada M, Yaoi T, Shimada J et al. Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. Oncol Rep 2005; 14(4): 817-22.
10. Lau QC, Raja E, Salto-Tellez M et al. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res 2006; 66(13): 6512-20.
11. Cho NY, Kim BH, Choi M et al. Hypermethylation of CpG island loci and hypomethylation of LINE-1 and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features. J Pathol 2007; 211(3): 269-77.
12. Yoshizaki T, Enomoto T, Fujita M et al. Frequent inactivation of RUNX3 in endometrial carcinoma. Gynecol Oncol 2008; 110(3): 439-44.
13. Ito K, Liu Q, Salto-Tellez M et al. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res 2005; 65(17): 7743-50.
14. He JF, Ge MH, Zhu X et al. Expression of RUNX3 in salivary adenoid cystic carcinoma: implications for tumor progression and prognosis. Cancer Sci 2008; 99(7): 1334-40.
15. Sobin LHWC. TNM Classification of Malignant Tumors, 6th edn. New York, NY: Wiley-Liss, 2002.
16. Barnes LEJ, Reichart P, Sidransky D. WHO Classification of Tumors: Pathology and Genetics of the Head and Neck Tumors. Lyon: IARC Press, 2005.
17. Sasahira T, Kirita T, Bhawal UK et al. The expression of receptor for advanced glycation end products is associated with angiogenesis in human oral squamous cell carcinoma. Virchows Arch 2007; 450(3): 287-95.
18. Sasahira T, Kirita T, Bhawal UK et al. Receptor for advanced glycation end products (RAGE) is important in the prediction of recurrence in human oral squamous cell carcinoma. Histopathology 2007; 51(2): 166-72.
19. Sasahira T, Kirita T, Oue N et al. High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma. Cancer Sci 2008; 99(9): 1806-12.
20. Sasahira T, Oue N, Kirita T et al. Reg IV expression is associated with cell growth and prognosis of adenoid cystic carcinoma in the salivary gland. Histopathology 2008; 53(6): 667-75.
21. Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998; 11(2): 155-68.
22. Sakakura C, Miyagawa K, Fukuda KI et al. Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosis. Oncogene 2007; 26(40): 5927-38.
23. Yamamura Y, Lee WL, Inoue K, Ida H, Ito Y. RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem 2006; 281(8): 5267-76.
24. Yano T, Ito K, Fukamachi H et al. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol 2006; 26(12): 4474-88.
25. Ito Y. Oncogenic potential of the RUNX gene family: 'overview'. Oncogene 2004; 23(24): 4198-208.
26. Stewart M, Terry A, Hu M et al. Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. Proc Natl Acad Sci U S A 1997; 94(16): 8646-51.
27. Barnes GL, Javed A, Waller SM et al. Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Cancer Res 2003; 63(10): 2631-7.
28. Szanto PA, Luna MA, Tortoledo ME, White RA. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer 1984; 54(6): 1062-9.
29. van der Wal JE, Snow GB, van der Waal I. Intraoral adenoid cystic carcinoma. The presence of perineural spread in relation to site, size, local extension, and metastatic spread in 22 cases. Cancer 1990; 66(9): 2031-3.
30. Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer 1998; 82(7): 1217-24.
31. Brandwein MS, Ivanov K, Wallace DI et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 2001; 25(7): 835-45.
32. Shintani S, Funayama T, Yoshihama Y et al. Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study. Anticancer Res 1995; 15(6B): 2623-6.
33. Sato K, Ueda Y, Sakurai A et al. Adenoid cystic carcinoma of the maxillary sinus with gradual histologic transformation to high-grade adenocarcinoma: a comparative report with dedifferentiated carcinoma. Virchows Arch 2006; 448(2): 204-8.
34. Franchi A, Gallo O, Bocciolini C, Franchi L, Paglierani M, Santucci M. Reduced E-cadherin expression correlates with unfavorable prognosis in adenoid cystic carcinoma of salivary glands of the oral cavity. Am J Clin Pathol 1999; 111(1): 43-50.
35. Takata T, Kudo Y, Zhao M et al. Reduced expression of p27(Kip1) protein in relation to salivary adenoid cystic carcinoma metastasis. Cancer 1999; 86(6): 928-35.
36. Tonon G, Modi S, Wu L et al. t (11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a notch signaling pathway. Nat Genet 2003; 33(2): 208-13.
37. Okabe M, Miyabe S, Nagatsuka H et al. MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res 2006; 12(13): 3902-7.