Buckwheat polysaccharide exerts antiproliferative effects in THP-1 human leukemia cells by inducing differentiation

Journal of Medicinal Food

Volumn 14, Issue 1-2, 2011, Pages 26-33

  Wu, She Ching ^a   Lee, Bao Hong ^a  

^a NATIONAL CHIAYI UNIVERSITY   (Taiwan)

Author keywords

buckwheat polysaccharide; differentiation inducer; differentiation therapy; leukemia; THP 1 cell

Indexed keywords

ANION; ANTILEUKEMIC AGENT; BUCKWHEAT POLYSACCHARIDE; CD11B ANTIGEN; CD14 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; PHYTOHEMAGGLUTININ; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BUCKWHEAT; CANCER INHIBITION; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY TEST; HUMAN; HUMAN CELL; LEUKEMIA CELL; MACROPHAGE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGOCYTOSIS; PRIORITY JOURNAL;

CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; FAGOPYRUM; GROWTH INHIBITORS; HUMANS; LEUKEMIA; LEUKOCYTES, MONONUCLEAR; PLANT EXTRACTS; POLYSACCHARIDES;

EID: 79952084002     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2010.1252     Document Type: Article

References (27)

1. Watanabe M: Catechins as antioxidants from buckwheat (Fagopyrum esculentum Moench) groats. J Agric Food Chem 1998;46:839-845.
2. Zhang M, Chen H, Li J, Pei Y, Liang Y: Antioxidant properties of tartary buckwheat extracts as affected by different thermal processing methods. LWT-Food Sci Technol 2010;43:181-185.
3. Liu CL, Chen YS, Yang JH, Chiang BH: Antioxidant activity of tartary (Fagopyrum tataricum (L.) Gaertn.) and common (Fagopyrum esculentum Moench) buckwheat sprouts. J Agric Food Chem 2008;56:173-178.
4. Lee JS, Bok SH, Jeon SM, Kim HJ, Do KM, Park YB, Choi MS: Antihyperlipidemic effects of buckwheat leaf and flower in rats fed a high-fat diet. Food Chem 2010;119:235-240.
5. Cao W, Chen WJ, Suo ZR, Yao YP: Protective effects of ethanolic extracts of buckwheat groats on DNA damage caused by hydroxyl radicals. Food Res Int 2008;41:924-929.
6. Castaigne S, Lefebvre P, Chomienne C, Suc E, Rigal-Huguet F, Gardin C, Delmer A, Archimbaud E, Tilly H, Janvier M: Effectiveness and pharmacokinetics of low-dose all-trans retinoic acid (25 mg/mL) in acute promyelocytic leukemia. Blood 1993;82:3560-3563. (Pubitemid 24006035)
7. Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, Zhu J, Tang W, Sun GL, Yang KQ, Chen Y, Zhou L, Fang ZW, Wang YT, Ma J, Zhang P, Zhang TD, Chen SJ, Chen Z, Wang ZY: Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997;89:3354-3360.
8. Liao HF, Chen YY, Yang YC, Wang CS, Chen YJ: Rice (Oryza sativa L.) inhibits growth and induces differentiation of human leukemic U937 cells through activation of peripheral blood mononuclear cells. Food Chem Toxicol 2006;44:1724-1729.
9. Chen-Deutsch X, Garay E, Zhang J, Harrison JS, Studzinski G: C-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D. Leukemia Res 2009;33:1372-1378.
10. Olsson IL, Breitman TR: Induction of differentiation of human histiocytic lymphoma cell line U937 by retinoic acid cyclic adenosine 30,50-monophosphate- inducing agents. Cancer Res 1982;42:3924-3927. (Pubitemid 13198542)
11. Im SA, Lee YR, Lee YH, Oh ST, Gerelchuluun T, Kim BH, Kim Y, Yun YP, Song S, Lee CK: Synergistic activation of monocytes by polysaccharides isolated from Salicornia herbacea and interferon-γ. J Ethnopharmacol 2007;111:365-370. (Pubitemid 46528084)
12. Chen YJ, Shiao MS, Lee SS, Wang SY: Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-2359.
13. Hsu JW, Huang HC, Chen ST, Wong CH, Juan HF: Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation. Evid Based Complement Alternat Med 2009 Aug 20 [Epub ahead of print] doi:10.1093/ecam/nep107.
14. Liao GF, Chou CJ, Wu SH, Chen CF, Wang SY: Isolation and characterization of an active compound from black soybean [Glycine max (L) Merr.] and its effect on proliferation and differentiation of human leukemic U937 cells. Anticancer Drug 2001;12:841-846.
15. Ou HT, Shieh CJ, Chen YJ, Chang MH: The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms. J Agric Food Chem 2005;53:300-305.
16. Chen YY, Chang HM: Antiproliferative and differentiating effects of polysaccharide fraction from fu-ling (Poria cocos) on human leukemic U937 and HL-60 cells. Food Chem Toxicol 2004;42:759-769.
17. Chan WK, Cheung CCH, Law HKW, Lau YL, Chan CF: Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into macrophage cells with immuno-stimulatory. J Hematol Oncol 2008;1:9-20.
18. Iyamu E, Perdew H, Woods G: Growth inhibitory and differentiation effects of chloroquine and its analogue on human leukemic cells potentiate fetal hemoglobin production by targeting the polyamine pathway. Biochem Pharmacol 2009;77:1021-1028.
19. Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK: The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer 1997;70:699-705.
20. Miyazaki T, Oikawa N, Yadomae T, Yamada H, Yamada Y: Relationship between the chemical structure and anti-tumor activity of glucans prepared from Grifora umbellata. Carbohydr Res 1979;69:165-170.
21. Yamada H, Kawaguchi N, Ohmori T, Takeshita Y, Taneya S, Miyazaki T: Structure and antitumor activity of an alkalisoluble polysaccharide from Cordyceps ophioglossoides. Carbohydr Res 1984;125:107-115.
22. Takeda Y, Tanaka M, Miyazaki H, Takeo S, Nomoto K, Yoshikai Y: Analysis of effector T cells against the murine syngeneic tumor MethA in mice orally administered antitumor polysaccharide SPR-901. Cancer Immunol Immunother 1994;38:143-148. (Pubitemid 24069222)
23. Takeo S, Kado H, Yamamoto H, Kamimura M, Watanabe N, Uchida K, Mori Y: Studies on an antitumor polysaccharide RBS derived from rice bran. II. Preparation and general properties of RON, an active fraction of RBS. Chem Pharm Bull 1988;36:3609-3613.
24. Guo X, Zhu K, Zhang H, Yao H: Purification and characterization of the antitumor protein from Chinese tartary buckwheat (Fagopyrum tataricum Gaertn.) water-soluble extracts. J Agric Food Chem 2007;55:6958-6961. (Pubitemid 47338932)
25. Hsu HY, Hua KF, Lin CC, Lin CH, Hsu J, Wong CH: Extract of reishi polysaccharides induces cytokine expression via TLR4- modulated protein kinase signaling pathways. J Immunol 2004;173:5989-5999. (Pubitemid 39487753)
26. Chen-Deutsch X, Garay E, Zhang J, Harrison JS, Studzinski GP: c-Jun-N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D. Leuk Res 2009;33:1372-1378.
27. Moosavi MA, Yazdanparast R, Lotfi A: ERK1/2 inactivation and p38 MAPK-dependent caspase activation during guanosine 50- triphosphate-mediated terminal erythroid differentiation of K562 cells. Int J Biochem Cell Biol 2007;39:1685-1697. (Pubitemid 47088312)