Flutamide for Androgen Excess: Low Dose is Best

Journal of Pediatric and Adolescent Gynecology

Volumn 24, Issue 2, 2011, Pages

  De Zegher, Francis ^a   Ibáñez, Lourdes ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FLUTAMIDE;

HIRSUTISM; HUMAN; HYPERANDROGENISM; LETTER; LIVER TOXICITY; LOW DRUG DOSE; PRIORITY JOURNAL;

ADOLESCENT; ANDROGEN ANTAGONISTS; FEMALE; FLUTAMIDE; HUMANS; HYPERANDROGENISM; YOUNG ADULT;

EID: 79952079114     PISSN: 10833188     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpag.2010.02.005     Document Type: Letter

References (8)

1. Wysowski D.K., Fourcroy J.L. Flutamide hepatotoxicity. J Urol 1996, 155:209.
2. Hero M., Jänne O.A., Näntö-Salonen K., et al. Circulating antiandrogenic activity in children with congenital adrenal hyperplasia during peroral flutamide treatment. J Clin Endocrinol Metab 2005, 90:5141.
3. Müderris, Bayram F., Güven M. Treatment of hirsutism with lowest-dose flutamide (62.5 mg/day). Gynecol Endocrinol 2000, 14:38.
4. Calaf J., López E., Millet A., et al. Spanish Working Group for Hirsutism: Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial. J Clin Endocrinol Metab 2007, 92:3446.
5. Ibáñez L., Valls C., Cabré S., et al. Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide. J Clin Endocrinol Metab 2004, 89:4716.
6. Ibáñez L., López-Bermejo A., Díaz M., et al. Low-dose pioglitazone and low-dose flutamide added to metformin and oestro-progestagens for hyperinsulinaemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months. Clin Endocrinol 2009, 71:351.
7. de Zegher F., Ibáñez L. Low-dose flutamide for women with androgen excess: anti-androgenic efficacy and hepatic safety. J Endocrinol Invest 2009, 32:83.
8. Unluhizarci K., Ozel D., Tanriverdi F., et al. A comparison between finasteride, flutamide, and finasteride plus flutamide combination in the treatment of hirsutism. J Endocrinol Invest 2009, 32:37.