Psychiatric Molecular Genetics and the Ethics of Social Promises

Journal of Bioethical Inquiry

Volumn 8, Issue 1, 2011, Pages 27-34

  Sadler, John Z ^a  

^a The University of Texas Southwestern Medical Center   (United States)

Author keywords

Ethics; Mental disorders; Molecular genetics; Psychiatry

Indexed keywords

EID: 79952068891     PISSN: 11767529     EISSN: 18724353     Source Type: Journal    
DOI: 10.1007/s11673-010-9273-z     Document Type: Article

References (40)

1. Abbott, A. 2008. Psychiatric genetics: The brains of the family. Nature 454(7201): 154-157.
2. Akil, H., et al. 2010. The future of psychiatric research: Genomes and neural circuits. Science 327: 1580-1581.
3. Arguello, P. A., and J. A. Gogos. 2006. Modeling madness in mice: one piece at a time. Neuron 52(1): 179-196.
4. Ayhan, Y., A. Sawa, et al. 2009. Animal models of gene-environment interactions in schizophrenia. Behavioural Brain Research 204(2): 274-281.
5. Burmeister, M., M. G. McInnis, et al. 2008. Psychiatric genetics: progress amid controversy. Nature Reviews. Genetics 9(7): 527-540.
6. Cohen-Woods, S., A. Schosser, et al. 2009. From age correction to genome-wide association. Acta Psychiatrica Scandinavica 120(5): 355-362.
7. Collins, F. 2010. Has the revolution arrived? Nature 464: 674-675.
8. DeLisi, L. E., and S. V. Faraone. 2006. When is a "positive" association truly a "positive" in psychiatric genetics? A commentary based on issues debated at the World Congress of Psychiatric Genetics, Boston, October 12-18, 2005. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics 141B(4): 319-322.
9. Grob, G. N., and H. H. Goldman. 2006. The dilemma of federal mental health policy: Radical reform or incremental change? New Brunswick: Rutgers University Press.
10. Hallmayer, J. F. 2004. Psychiatric genetics: what to expect. Current Psychiatry Reports 6(3): 149-150.
11. Healy, D. 1997. The antidepressant era. Cambridge: Harvard University Press.
12. Healy, D. 2002. The creation of psychopharmacology. Cambridge: Harvard University Press.
13. Holden, C. 2009. Depression gene. Back to the drawing board for psychiatric genetics. Science 324(5935): 1628.
14. Hough, C. J., and R. J. Ursano. 2006. A guide to the genetics of psychiatric disease. Psychiatry 69(1): 1-20.
15. Insel, T. R. 2009. Disruptive insights in psychiatry: transforming a clinical discipline. The Journal of Clinical Investigation 119(4): 700-705.
16. Insel, T. R., and T. Lehner. 2007. A new era in psychiatric genetics? Biological Psychiatry 61(9): 1017-1018.
17. Insel, T. R., and P. S. Wang. 2010. Rethinking mental illness. JAMA 303(19): 1970-1971.
18. Keller, M. C., and G. Miller. 2006. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? The Behavioral and Brain Sciences 29(4): 385-404.
19. Kendler, K. S. 2005a. Psychiatric genetics: a methodologic critique. The American Journal of Psychiatry 162(1): 3-11.
20. Kendler, K. S. 2005b. "A gene for...": the nature of gene action in psychiatric disorders. The American Journal of Psychiatry 162(7): 1243-1252.
21. Kendler, K. S., and R. J. Greenspan. 2006. The nature of genetic influences on behavior: lessons from "simpler" organisms. The American Journal of Psychiatry 163(10): 1683-1694.
22. Khoury, M. J., J. Evans, and W. Burk. 2010. A reality check for personalized medicine. Nature 464: 680.
23. Laporte, J. L., R. F. Ren-Patterson, et al. 2008. Refining psychiatric genetics: From 'mouse psychiatry' to understanding complex human disorders. Behavioural Pharmacology 19(5-6): 377-384.
24. Levinson, D. F. 2005. Meta-analysis in psychiatric genetics. Current Psychiatry Reports 7(2): 143-151.
25. Lewis, S., and J. Lieberman. 2008. CATIE and CutLASS? Can we handle the truth? The British Journal of Psychiatry 192: 161-163.
26. Li, M. D. 2010. Grand challenges and opportunities for molecular psychiatry research: A perspective. Frontiers in Psychiatry 1: 1-3.
27. Maher, B. S., B. P. Riley, and K. S. Kendler. 2008. Psychiatric genetics gets a boost. Nature Genetics 40(9): 1042-1044.
28. McClellan, J., and M.-C. King. 2010. Genomic analysis of mental illness: A changing landscape. JAMA 303(24): 2523-2524.
29. Morrissey, J. P., and H. H. Goldman. 1984. Cycles of reform in the care of the chronic mentally ill. Hospital & Community Psychiatry 35(8): 785-793.
30. Satcher, D. (1999). Mental health: A report of the surgeon general. http://www. surgeongeneral. gov/library/mentalhealth/home. html. Accessed 8/3/2010.
31. Moffitt, T. E., A. Caspi, et al. 2005. Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry 62(5): 473-481.
32. Owen, M. J., N. Craddock, and M. C. O'Donovan. 2010. Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Archives of General Psychiatry 67(7): 667-673.
33. Peedicayil, J. 2002. The importance of cultural inheritance in psychiatric genetics. Medical Hypotheses 58(2): 164-166.
34. Prathikanti, S., and D. R. Weinberger. 2005. Psychiatric genetics-the new era: genetic research and some clinical implications. British Medical Bulletin 73-74: 107-122.
35. President's New Freedom Commission on Mental Health. (2002). Achieving the promise: Transforming mental health care in America. Available at: (http://www. mentalhealthcommission. gov/index. html). Accessed 8/3/2010.
36. Sadler, J. Z. 2005. Values and psychiatric diagnosis. Oxford: Oxford University Press.
37. Sadler, J. Z. 2009. Commentary: Stigma, conscience, and science in psychiatry: Past, present, and future. Academic Medicine 84(4): 413-417.
38. Venter, J. C. 2010. Multiple genomes await. Nature 464: 676-677.
39. Warden, D., A. J. Rush, M. H. Trivedi, M. Fava, and S. R. Wisniewski. 2007. The STAR*D project results: A comprehensive review of findings. Current Psychiatry Reports 9: 449-459.
40. Züchner, S., et al. 2007. Update on psychiatric genetics. Genetics in Medicine 9(6): 332-340.