Commentary: Testosterone and the metabolic syndrome: Cause or consequence?

International Journal of Epidemiology

Volumn 40, Issue 1, 2011, Pages 207-209

  Aled Rees, D A ^a   Dayan, Colin M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

BODY MASS; HUMAN; INSULIN RESISTANCE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTE; OBESITY; PRIORITY JOURNAL; WAIST HIP RATIO;

ADIPOSITY; CAUSALITY; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; SEX FACTORS; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 79952052485     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyq254     Document Type: Note

References (12)

1. Brand J, van der Tweel I, Grobbee D, Emmelot-Vonk M, van der Schouw Y. Testosterone, SHBG and the metabolic syndrome: a systematic review and meta-analysis of observational studies. Int J Epidemiol 2010.
2. Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2006;295: 1288-99.
3. Grossmann M, Gianatti EJ, Zajac JD. Testosterone and type 2 diabetes. Curr Opin Endocrinol Diabetes Obes 2010; 17:247-56.
4. Tsai EC, Matsumoto AM, Fujimoto WY, Boyko EJ. Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care 2004;27:861-68.
5. Kupelian V, Page ST, Araujo AB. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with the development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab 2006;91:843-50.
6. Biswas M, Hampton D, Turkes A, Newcombe RG, Rees DA. Reduced total testosterone concentrations in young healthy South Asian men are partly explained by increased insulin resistance but not by altered adiposity. Clin Endocrinol 2010;73:457-62.
7. Yki-Jarvinen H, Makimattila S, Utriainen T, Rutanen EM. Portal insulin concentrations rather than insulin sensitivity regulate serum sex hormone-binding globulin and insulin-like growth factor binding protein 1 in vivo. J Clin Endocrinol Metab 1995;80:3227-32.
8. Ding EL, Song Y, Manson JE. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009;361:1152-63.
9. Perry JR, Weedon MN, Langenberg C et al. Genetic evidence that raised sex hormone-binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 2010;19:535-44.
10. Gambineri A, Patton L, Vaccina A et al. Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study. J Clin Endocrinol Metab 2006; 91:3970-80.
11. Agarwal N, Rice SPL, Bolusani H et al. Metformin reduces arterial stiffness and improves endothelial function in young women with Polycystic Ovary Syndrome: a rando mized, placebo-controlled, crossover trial. J Clin Endocrinol Metab 2010;95:722-30.
12. Laaksonen DE, Niskanen L, Punnonen K. The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study. J Clin Endocrinol Metab 2005;90:712-19.