Genome gains at chromosome 21q21/22 segment leads to co-amplification of Down Syndrome Critical Regions and known oncogenes in a case of donor cell-derived acute myeloid leukaemia following allogeneic sex mismatched umbilical cord blood transplantation for chronic myeloid leukaemia

British Journal of Haematology

Volumn 151, Issue 3, 2010, Pages 285-288

  Castleton, Anna Z ^a   Brazma, Diana ^a   Howard Reeves, Julie ^a   Chanalaris, Anastasios ^a   Glanville, Julie ^a   Nizetic, Dean ^b   Chakraverty, Ronjon ^a   Nacheva, Elisabeth P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Donor cell derived leukaemia; DSCR genes; Oncogenic co amplification; RUNX1; Umbilical cord blood transplantation

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE MEGAKARYOCYTIC LEUKEMIA; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; BCR ABL1 FUSION GENE; BONE MARROW EXAMINATION; CASE REPORT; CHROMOSOME 17; CHROMOSOME 21Q; CHROMOSOME 21Q21; CHROMOSOME 21Q22; CHROMOSOME 7; CHROMOSOME LOSS; CHRONIC MYELOID LEUKEMIA; COMPARATIVE GENOMIC HYBRIDIZATION; CORD BLOOD STEM CELL TRANSPLANTATION; DEATH; DONOR CELL DERIVED LEUKEMIA; DOWN SYNDROME ADHESION MOLECULE GENE; DOWN SYNDROME CRITICAL REGION GENE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE; GENETIC GAIN; HUMAN; IMMUNOPHENOTYPING; INDUCTION CHEMOTHERAPY; KARYOTYPE 44,XY; LEUKEMIA REMISSION; MYELOBLAST; ONCOGENE; PHILADELPHIA 1 CHROMOSOME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; RUNX1 GENE; SEPSIS; SEX CHROMOSOME ABERRATION; CHROMOSOME 21; DONOR; GENE AMPLIFICATION; GENETICS; KARYOTYPING; LETTER; MALE;

ADULT; CHROMOSOMES, HUMAN, PAIR 21; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; GENE AMPLIFICATION; HUMANS; KARYOTYPING; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, MYELOID, ACUTE; MALE; ONCOGENES; TISSUE DONORS;

EID: 79952045136     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08350.x     Document Type: Article

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