Centralized treatment of advanced stages of ovarian cancer improves survival: A nationwide Danish survey

Acta Obstetricia et Gynecologica Scandinavica

Volumn 90, Issue 3, 2011, Pages 273-279

  Fagö Olsen, Carsten L ^a   Høgdall, Claus ^a   Kehlet, Henrik ^b   Christensen, Ib J ^c   Ottesen, Bent ^a  

^a Rigshospitalet   (Denmark)

^b Juliane Marie Centre   (Denmark)

^c FINSEN LABORATORY   (Denmark)

Author keywords

Centralization; ovarian cancer; overall survival; quality of treatment

Indexed keywords

ADVANCED CANCER; ARTICLE; CANCER ADJUVANT THERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CYTOREDUCTIVE SURGERY; DENMARK; HAZARD RATIO; HEALTH SURVEY; HUMAN; MAJOR CLINICAL STUDY; OVARY CANCER; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; TREATMENT OUTCOME;

ADULT; CANCER CARE FACILITIES; DENMARK; DISEASE PROGRESSION; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM STAGING; ONCOLOGY SERVICE, HOSPITAL; OVARIAN NEOPLASMS; PATIENT SELECTION; POPULATION SURVEILLANCE; PRIMARY HEALTH CARE; PROGNOSIS; REFERRAL AND CONSULTATION; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TREATMENT OUTCOME; WOMEN'S HEALTH;

EID: 79952013658     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1111/j.1600-0412.2010.01043.x     Document Type: Article

References (30)

1. Kjaerbye-Thygesen A, Huusom LD, Frederiksen K, Kjaer SK,. Trends in the incidence and mortality of ovarian cancer in Denmark 1978-2002. Comparison with other Nordic countries. Acta Obstet Gynecol Scand. 2005; 84: 1006-12. (Pubitemid 41400305)
2. Kræft i Danmark. København: Sundhedsstyrelsen, 2005. [Cancer in Denmark. Copenhagen: The National Board of Health, 2005] (in Danish. No abstract available). Available online at: (accessed 1 November 2010).
3. Dansk Gynækologisk Cancer Gruppe. Retningslinier for visitation, diagnostik og kontrol af epitelial ovarie-, tuba- og primær peritonealcancer samt borderline tumorer, 3. udgave. [Instructions for referral, diagnostics and control of epithelial ovarian- fallopian tube- and primary peritoneal cancer plus borderline tumors, 3rd edn] (in Danish. No abstract available). 2009. Available online at: (accessed 1 November 2010).
4. Eisenkop SM, Spirtos NM, Lin WC,. "Optimal" cytoreduction for advanced epithelial ovarian cancer: a commentary. Gynecol Oncol. 2006; 103: 329-35. (Pubitemid 44389875)
5. Bristow RE, Tomacruz RS, Armstrong DK, Trimble EL, Montz FJ,. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol. 2002; 20: 1248-59. (Pubitemid 34177431)
6. Oksefjell H, Sandstad B, Trope C,. Improved survival for stage IIIC ovarian cancer patients treated at the Norwegian Radium Hospital between 1984 and 2001. Eur J Gynaecol Oncol. 2007; 28: 256-62. (Pubitemid 47237990)
7. Vergote I, De Wever I, Tjalma W, Van Gramberen M, Decloedt J, van Dam P,. Neoadjuvant chemotherapy or primary debulking surgery in advanced ovarian carcinoma: a retrospective analysis of 285 patients. Gynecol Oncol. 1998; 71: 431-6. (Pubitemid 29022333)
8. Aletti GD, Dowdy SC, Gostout BS, Jones MB, Stanhope CR, Wilson TO, et al,. Aggressive surgical effort and improved survival in advanced-stage ovarian cancer. Obstet Gynecol. 2006; 107: 77-85.
9. Chi DS, Franklin CC, Levine DA, Akselrod F, Sabbatini P, Jarnagin WR, et al,. Improved optimal cytoreduction rates for stages IIIC and IV epithelial ovarian, fallopian tube, and primary peritoneal cancer: a change in surgical approach. Gynecol Oncol. 2004; 94: 650-4. (Pubitemid 39194456)
10. Marx C, Bendixen A, Hogdall C, Ottosen C, Kehlet H, Ottesen B,. Organisation and quality of primary surgical intervention for ovarian cancer in Denmark. Acta Obstet Gynecol Scand. 2007; 86: 1496-502. (Pubitemid 350135583)
11. Vernooij F, Heintz P, Witteveen E, van der Graaf Y,. The outcomes of ovarian cancer treatment are better when provided by gynecologic oncologists and in specialized hospitals: a systematic review. Gynecol Oncol. 2007; 105: 801-12. (Pubitemid 46734206)
12. Engelen MJ, Kos HE, Willemse PH, Aalders JG, de Vries EG, Schaapveld M, et al,. Surgery by consultant gynecologic oncologists improves survival in patients with ovarian carcinoma. Cancer. 2006; 106: 589-98. (Pubitemid 43157622)
13. Paulsen T, Kjaerheim K, Kaern J, Tretli S, Trope C,. Improved short-term survival for advanced ovarian, tubal, and peritoneal cancer patients operated at teaching hospitals. Int J Gynecol Cancer. 2006; 16 (Suppl 1): 11-7.
14. Kumpulainen S, Kuoppala T, Leminen A, Penttinen J, Puistola U, Pukkala E, et al,. Surgical treatment of ovarian cancer in different hospital categories-a prospective nation-wide study in Finland. Eur J Cancer. 2006; 42: 388-95. (Pubitemid 43132895)
15. Specialeplanlægning og lands-landsdelsfunktioner i sygehusvæsenet. Sundhedsstyrelsens vejledning vedrørende specialeplanlægning og lands-landsdelsfunktioner i sygehusvæsenet. København: Sundhedsstyrelsen, 2001. [Specialty Planning and country-region functions in the hospitals. Board of Health guidance for specialty programming and country-region functions in hospitals. Copenhagen: The Danish National Board of Health, 2001] (in Danish. No abstract available). Available online at: (accessed 1 November 2010).
16. Marx CI, Moller C, Bendixen A, Kehlet H, Ottesen BS,. Ovariekræft i Danmark-Status for den kirurgiske indsats. [Ovarian cancer in Denmark. Status of the surgical intervention] (in Danish with English abstract). Ugeskr Laeger. 2006; 168: 1537-40.
17. Ottesen B, Iversen MG, Kehlet H,. Operation for ovariecancer i Danmark 2004-2007. [Surgical treatment for ovarian cancer in Denmark 2004-2007] (in Danish with English abstract). Ugeskr Laeger. 2009; 171: 217-20.
18. Ioka A, Tsukuma H, Ajiki W, Oshima A,. Influence of hospital procedure volume on ovarian cancer survival in Japan, a country with low incidence of ovarian cancer. Cancer Sci. 2004; 95: 233-7. (Pubitemid 38489089)
19. Kumpulainen S, Grenman S, Kyyronen P, Pukkala E, Sankila R,. Evidence of benefit from centralised treatment of ovarian cancer: a nationwide population-based survival analysis in Finland. Int J Cancer. 2002; 102: 541-4. (Pubitemid 35316012)
20. Schrag D, Earle C, Xu F, Panageas KS, Yabroff KR, Bristow RE, et al,. Associations between hospital and surgeon procedure volumes and patient outcomes after ovarian cancer resection. J Natl Cancer Inst. 2006; 98: 163-71. (Pubitemid 43205478)
21. Kumpulainen S, Sankila R, Leminen A, Kuoppala T, Komulainen M, Puistola U, et al,. The effect of hospital operative volume, residual tumor and first-line chemotherapy on survival of ovarian cancer-a prospective nation-wide study in Finland. Gynecol Oncol. 2009; 115: 199-203.
22. Tingulstad S, Skjeldestad FE, Hagen B,. The effect of centralization of primary surgery on survival in ovarian cancer patients. Obstet Gynecol. 2003; 102: 499-505. (Pubitemid 37311211)
23. Aletti GD, Dowdy SC, Podratz KC, Cliby WA,. Relationship among surgical complexity, short-term morbidity, and overall survival in primary surgery for advanced ovarian cancer. Am J Obstet Gynecol. 2007; 197: 676-7.
24. Maggioni A, Benedetti PP, Dell'Anna T, Landoni F, Lissoni A, Pellegrino A, et al,. Randomised study of systematic lymphadenectomy in patients with epithelial ovarian cancer macroscopically confined to the pelvis. Br J Cancer. 2006; 95: 699-704. (Pubitemid 44373484)
25. Young RC, Decker DG, Wharton JT, Piver MS, Sindelar WF, Edwards BK, et al,. Staging laparotomy in early ovarian cancer. JAMA. 1983; 250: 3072-6. (Pubitemid 14201622)
26. Dansk Gynækologisk Cancer Database. Årsrapport 2008. [Danish Gynecological Cancer Database. Annual Report 2008] (in Danish. No abstract available). 2010. Available online at: (accessed November 1, 2010).
27. Cliby WA, Aletti GD, Wilson TO, Podratz KC,. Is it justified to classify patients to Stage IIIC epithelial ovarian cancer based on nodal involvement only? Gynecol Oncol. 2006; 103: 797-801. (Pubitemid 44821353)
28. Voest EE, van Houwelingen JC, Neijt JP,. A meta-analysis of prognostic factors in advanced ovarian cancer with median survival and overall survival (measured with the log (relative risk)) as main objectives. Eur J Cancer Clin Oncol. 1989; 25: 711-20. (Pubitemid 19096441)
29. Weinberg LE, Rodriguez G, Hurteau JA,. The role of neoadjuvant chemotherapy in treating advanced epithelial ovarian cancer. J Surg Oncol. 2010; 101: 334-43.
30. Vergote I, Trope CG, Amant F, Kristensen GB, Ehlen T, Johnson N, et al,. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med. 2010; 363: 943-53.