Physiological and pathophysiological roles of adenosine

Sleep and Biological Rhythms

Volumn 9, Issue SUPPL. 1, 2011, Pages 24-28

  Fredholm, Bertil B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adaptive responses; Adenine nucleotides; Adenosine; Adenosine receptors; Caffeine

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE TRIPHOSPHATE; ADENINE NUCLEOTIDE; ADENOSINE RECEPTOR; CYCLIC AMP; GAP JUNCTION PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PURINERGIC P2X RECEPTOR;

DRUG ACTIVITY; DRUG EFFECT; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; REVIEW; SLEEP; SLEEP WAKING CYCLE; WAKEFULNESS; ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; CELL COMMUNICATION; CONTROLLED STUDY; DNA MODIFICATION; ENZYME ACTIVATION; EXOCYTOSIS; GAP JUNCTION; LYSOSOME; MOUSE; NEUROTRANSMITTER RELEASE; PATHOPHYSIOLOGY; PHYSIOLOGICAL PROCESS; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN SECRETION;

EID: 79951997893     PISSN: 14469235     EISSN: 14798425     Source Type: Journal    
DOI: 10.1111/j.1479-8425.2010.00460.x     Document Type: Review

References (43)

1. Ishimori K. True cause of sleep: a hypnogenic substance as evidenced in the brain of sleep-deprived animals. Tokyo Igakkai Zasshi 1909; 23: 429-59.
2. Mathieu-Levy N. [Contribution to the mechanism of potentiation of experimental sleep by adenosine triphosphoric acid (ATP). On some ATP actions at the level of the central nervous system]. [French]. Therapie 1968; 23: 1157-73.
3. Radulovacki M, Virus RM, Djuricic-Nedelson M, Green RD. Adenosine analogs and sleep in rats. J. Pharmacol. Exp. Ther. 1984; 228: 268-74.
4. Newby AC. Adenosine and the concept of "retaliatory metabolites". Trends. Biochem. 1984; 9: 42-4.
5. Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 2001; 53: 527-52.
6. Fredholm BB, Arslan G, Halldner L, Kull B, Schulte G, Wasserman W. Structure and function of adenosine receptors and their genes. Naunyn Schmiedebergs Arch. Pharmacol. 2000; 362 (4-5): 364-74.
7. Parkinson FE, Fredholm BB. Magnesium-dependent enhancement of endogenous agonist binding to A1 adenosine receptors: a complicating factor in quantitative autoradiography. J. Neurochem. 1992; 58 (3): 941-50.
8. Arslan G, Kull B, Fredholm BB. Signaling via A2A adenosine receptor in four PC12 cell clones. Naunyn Schmiedebergs Arch. Pharmacol. 1999; 359 (1): 28-32.
9. Johansson B, Halldner L, Dunwiddie TV etal. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc. Natl. Acad. Sci. U. S. A. 2001; 98 (16): 9407-12.
10. Fredholm BB, Irenius E, Kull B, Schulte G. Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem. Pharmacol. 2001; 61: 443-8.
11. Schulte G, Fredholm BB. Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2. Mol. Pharmacol. 2000; 58: 477-82.
12. King AE, Ackley MA, Cass CE, Young JD, Baldwin SA. Nucleoside transporters: from scavengers to novel therapeutic targets. Trends. Pharmacol. Sci. 2006; 27 (8): 416-25.
13. Ballarín M, Fredholm BB, Ambrosio S, Mahy N. Extracellular levels of adenosine and its metabolites in the striatum of awake rats: inhibition of uptake and metabolism. Acta Physiol. Scand. 1991; 142: 97-103.
14. Burnstock G. Historical review: ATP as a neurotransmitter. Trends. Pharmacol. Sci. 2006; 27: 166-76.
15. Fredholm BB, Fried G, Hedqvist P. Origin of adenosine released from rat vas deferens by nerve stimulation. Eur. J. Pharmacol. 1982; 79 (3-4): 233-43.
16. Okada SF, Nicholas RA, Kreda SM, Lazarowski ER, Boucher RC. Physiological regulation of ATP release at the apical surface of human airway epithelia. J. Biol. Chem. 2006; 281 (32): 22992-3002.
17. Robson SC, Wu Y, Sun X, Knosalla C, Dwyer K, Enjyoji K. Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation. Semin. Thromb. Hemost. 2005; 31: 217-33.
18. Picher M, Burch LH, Hirsh AJ, Spychala J, Boucher RC. Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways. J. Biol. Chem. 2003; 278 (15): 13468-79.
19. MacDonald PE, Braun M, Galvanovskis J, Rorsman P. Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells. Cell Metab. 2006; 4: 283-90.
20. Zhang Q, Li Y, Tsien RW. The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science 2009; 323 (5920): 1448-53.
21. Spray DC, Ye ZC, Ransom BR. Functional connexin "hemichannels": a critical appraisal. Glia 2006; 54: 758-73.
22. Dale N. Dynamic ATP signalling and neural development. J. Physiol. 2008; 586: 2429-36.
23. Schulz R, Heusch G. Connexin43 and ischemic preconditioning. Adv. Cardiol. 2006; 42: 213-27.
24. Lazarowski ER, Boucher RC, Harden TK. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol. Pharmacol. 2003; 64: 785-95.
25. Zhang Z, Chen G, Zhou W etal. Regulated ATP release from astrocytes through lysosome exocytosis. Nat. Cell. Biol. 2007; 9: 945-53.
26. Halassa MM, Florian C, Fellin T etal. Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron 2009; 61 (2): 213-19.
27. Zetterström T, Vernet L, Ungerstedt U, Tossman U, Jonzon B, Fredholm BB. Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre. Neurosci. Lett. 1982; 29: 111-15.
28. Andiné P, Rudolphi KA, Fredholm BB, Hagberg H. Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia. Br. J. Pharmacol. 1990; 100: 814-18.
29. Pedata F, Corsi C, Melani A, Bordoni F, Latini S. Adenosine extracellular brain concentrations and role of A2A receptors in ischemia. Ann. N. Y. Acad. Sci. 2001; 939: 74-84.
30. Dux E, Fastbom J, Ungerstedt U, Rudolphi K, Fredholm BB. Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus. Brain Res. 1990; 516: 248-56.
31. Kiesman WF, Elzein E, Zablocki J. A1 adenosine receptor antagonists, agonists, and allosteric enhancers. Handb. Exp. Pharmacol. 2009; 193: 25-58.
32. Cristalli G, Müller CE, Volpini R. Recent developments in adenosine A2A receptor ligands. Handb. Exp. Pharmacol. 2009; 193: 59-98.
33. Kalla RV, Zablocki J, Tabrizi MA, Baraldi PG. Recent developments in A2B adenosine receptor ligands. Handb. Exp. Pharmacol. 2009; 193: 99-122.
34. Jacobson KA, Klutz AM, Tosh DK, Ivanov AA, Preti D, Baraldi PG. Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering. Handb. Exp. Pharmacol. 2009; 193: 123-59.
35. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol. Rev. 1999; 51: 83-133.
36. Ledent C, Vaugeois JM, Schiffmann SN etal. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2A receptor. Nature 1997; 388: 674-8.
37. Salvatore CA, Tilley SL, Latour AM, Fletcher DS, Koller BH, Jacobson MA. Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells. J. Biol. Chem. 2000; 275 (6): 4429-34.
38. Yaar R, Jones MR, Chen JF, Ravid K. Animal models for the study of adenosine receptor function. J. Cell. Physiol. 2005; 202 (1): 9-20.
39. Popescu FD, Popescu F. A review of antisense therapeutic interventions for molecular biological targets in asthma. Biologics 2007; 1: 271-83.
40. Johansson S, Yang J, Lindgren E, Fredholm BB. Eliminating the antilipolytic adenosine A1 receptor does not lead to compensatory changes of PGE2 or nicotinic acid effects on lipolysis. Acta Physiol. 2007; 190: 87-96.
41. Porkka-Heiskanen T, Alanko L, Kalinchuk A, Stenberg D. Adenosine and sleep. Sleep Med. Rev. 2002; 6: 321-32.
42. Stenberg D, Litonius E, Halldner L, Johansson B, Fredholm BB, Porkka-Heiskanen T. Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor. J. Sleep. Res. 2003; 12: 283-90.
43. 1, receptors mediate the arousal effect of caffeine. Nat. Neurosci. 2005; 8: 858-9.