Treatment of infrabony defects with or without enamel matrix proteins: A 24-month follow-up randomized pilot study

Quintessence International

Volumn 41, Issue 2, 2010, Pages 125-134

  Chambrone, Daniela ^a,b   Pasin, Ivan Munhoz ^a   Chambrone, Leandro ^a   Pannuti, Claudio Mendes ^a   Conde, Marina Clemente ^a   Lima, Luiz A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE METODISTA DE SÃO PAULO   (Brazil)

Author keywords

Enamel matrix proteins; Infrabony defects; Periodontal diseases; Periodontal therapy; Randomized clinical trials; Regenerative periodontal therapy

Indexed keywords

ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN;

ADULT; ALVEOLAR BONE LOSS; ARTICLE; BONE REGENERATION; CHRONIC PERIODONTITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GINGIVA DISEASE; HUMAN; MALE; MIDDLE AGED; NONPARAMETRIC TEST; PERIODONTAL DEBRIDEMENT; PERIODONTAL DISEASE; PERIODONTAL POCKET; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ADULT; ALVEOLAR BONE LOSS; BONE REGENERATION; CHRONIC PERIODONTITIS; DENTAL ENAMEL PROTEINS; FEMALE; GINGIVAL RECESSION; HUMANS; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL DEBRIDEMENT; PERIODONTAL POCKET; PILOT PROJECTS; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 79951991444     PISSN: 00336572     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Heijl L, Heden G, Svärdström G, Östgren A. Enamel matrix derivative (Emdogain) in the treatment of intrabony periodontal defects. J Clin Periodontol 1997;24(part II): 705-714.
2. Froum SJ, Weinberg MA, Rosenberg E, Tarnow D. A comparative study utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: A 12- month re-entry study. J Periodontol 2001;72: 25-34.
3. Rösing CK, Aass AM, Mavropoulos A, Gjermo P. Clinical and radiographic effects of enamel matrix derivative in the treatment of intrabony periodontal defects: A 12-month longitudinal placebocontrolled clinical trial in adult periodontitis patients. J Periodontol 2005;76: 129-133.
4. Sculean A, Donos N, Miliauskaite A, Arweiler N, Brecx M. Treatment of intrabony defects with enamel matrix proteins or bioabsorbable membrane. A 4-year follow-up split-mouth study. J Periodontol 2001;72: 1695-1701.
5. Sculean A, Donos N, Schwarz F, Becker J, Brecx M, Arweiler NB. Five-year results following treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. J Clin Periodontol 2004;31: 545-549.
6. Sculean A, Pietruska M, Schwarz F, Willershausen B, Arweiler NB, Auschill TM. Healing of human infrabony defects following regenerative periodontal therapy with an email matrix protein derivative alone or combined with a bioactive glass. A controlled clinical study. J Clin Periodontol 2005;32: 111-117.
7. Sculean A, Schwarz F, Miliauskaite A, et al.Treatment of infrabony defects with an enamel matrix protein derivative or bioabsorbable membrane: An 8-year follow-up split-mouth study. J Periodontol 2006;77: 1879-1886.
8. Sculean A, Pietruska M, Arweiler NB, Auschill TM. Four-year results of a prospective-controlled clinical study evaluating healing of infra-bony defects following treatment with protein derivative alone or combined with a bioactive glass. J Clin Periodontol 2007;34: 507-513.
9. Tonetti MS, Lang NP, Cortellini P, et al. Enamel matrix proteins in the regenerative therapy of deep infrabony defects. J Clin Periodontol 2002;29: 317-325.
10. Tonetti MS, Fourmousis I, Suvan J, Cortellini P, Bragger U, Lang NP.Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep infrabony defects. J Clin Periodontol 2004;31: 1092-1099.
11. Zucchelli G, Bernardi F, Montebugnoli L, De Sanctis M.Enamel matrix proteins and guided tissue regeneration with titanium-reinforced expanded polytetrafluoroethylene membranes in the treatment of intrabony defects: A comparative controlled clinical trial. J Periodontol 2002;73: 3-12.
12. Lekovic V, Camargo PM, Weinlaender M, Nedic M, Aleksic Z, Kenney EB. A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans. J Periodontol 2000;71: 1110-1116.
13. Windisch P, Sculean A, Klein F, et al. Comparison of clinical, radiographic, and histometric measurements following treatment with guided tissue regeneration or enamel matrix proteins in human periodontal defects. J Periodontol 2002;73: 409-417.
14. Sanz M, Tonetti MS, Zabalegui I, et al. Treatment of infrabony defects with enamel matrix proteins or barrier membranes: Results from a multicenter practice- based clinical trial. J Periodontol 2004;75: 726-733.
15. Döri F, Arweiler N, Gera I, Sculean A. Clinical evaluation of an enamel matrix protein derivative combined with either a natural bone mineral or _-tricalcium phosphate. J Periodontol 2005;76: 2236-2243.
16. Gestrelius S, Andersson C, Lidström D, Hammarström L, Somerman M. In vitro studies on periodontal ligament cells and enamel matrix derivative. J Clin Periodontol 1997;24(part II): 685-692.
17. Kawase T, Okuda K, Yoshie H, Burns DM. Cytostatic action of enamel matrix derivative (Emdogain) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. J Periodontal Res 2000;35: 291-300.
18. Lyngstadaas SP, Lundberg E, Ekdahl H, Andersson C, Gestrelius S. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontol 2001;28: 181-188.
19. Araújo MG, Hayacibara R, Sonohara M, Cardaropoli G, Lindhe J. Effect of enamel matrix protein (Emdogain) on healing after re-implantation of 'periodontally compromised' roots. An experimental study in the dog. J Clin Periodontol 2003;30: 855-861.
20. Hamamoto Y, Kawasaki N, Jarnbring F, Hammartröm L. Effects and distribution of the enamel matrix derivative Emdogain in the periodontal tissues of rat molars transplanted to the abdominal wall.Dent Traumatol 2002;18: 12-23.
21. Hammarström L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997; 24(part II): 658-668.
22. Francetti L, Del Fabbro M, Basso M, Testori R, Weinstein R. Enamel matrix proteins in the treatment of intra-bony defect. A prospective 24-month clinical trial. J Clin Periodontol 2004;31: 52-59.
23. Camargo PM, Lekovic V, Weinlaender M, Vasilic N, Barrie Kenney E, Madzarevic M.The effectiveness of enamel matrix proteins used in combination with bovine porous bone mineral in the treatment of intrabony defects in humans. J Clin Periodontol 2001;28: 1016-1022.
24. Okuda K, Momose M, Miyazaki A, et al.Enamel matrix derivative in the treatment of human intrabony osseous defects. J Periodontol 2000;71: 1821-1828.
25. Pontoriero R, Wennström J, Lindhe J.The use of barrier membranes and enamel matrix proteins in the treatment of angular bone defects. A prospective controlled clinical study. J Clin Periodontol 1999;26: 833-840.
26. Wachtel H, Schenk G, Böhm S, Weng D, Zuhr O, Hürzeler MB. Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: A controlled clinical study. J Clin Periodontol 2003;30: 496-504.
27. Zetterström O, Andersson C, Eriksson L, et al. Clinical safety of enamel matrix derivative (Emdogain) in the treatment of periodontal defects. J Clin Periodontol 1997;24: 697-704.
28. Sculean A, Blaes A, Arweiler N, Reich E, Donos N, Brecx M. The effect of postsurgical antibiotics on the healing of intrabony defects following treatment with enamel matrix proteins. J Periodontol 2001;72: 190-195.
29. Chambrone D, Pasin IM, Conde MC, Panutti C, Carneiro S, Lima LA. Effect of enamel matrix proteins on the treatment of intrabony defects: A splitmouth randomized controlled trial study. Braz Oral Res 2007;21: 241-246.
30. Esposito M, Grusovin MG, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in infrabony defects. Cochrane Database Syst Rev 2005;(4): CD003875.
31. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4: 1-6.
32. O'Leary TJ, Drake RB, Naylor JE. The plaque control record. J Periodontol 1972;43: 38.
33. Silness J, Löe H.Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition.Acta Odontol Scand 1964;22: 121-135.
34. Löe H.The gingival index, the plaque index and the retention index system. J Periodontol 1967;38: 610-616.
35. Reddy MS. The use of periodontal probes and radiographs in clinical trials of diagnostic tests. Ann Periodontol 1997;2: 113-122.
36. Kirkwood BR. Essentials of Medical Statistics. Oxford: Blackwell Scientific, 1988: 224.
37. Lekovic V, Camargo PM, Weinlaender M, Kenney EB, Vasilic N. Combination use of bovine porous bone mineral, enamel matrix proteins, and a bioabsorbable membrane in intrabony periodontal defects in humans. J Periodontol 2001;72: 583-589.
38. Pietruska MD. A comparative study on the use of Bio-Oss and enamel matrix derivative (Emdogain) in the treatment of periodontal bone defects. Eur J Oral Sci 2001;109: 178-181.
39. Velasquez-Plata D, Todd Scheyer E, Mellonig JT. Clinical comparison of an enamel matrix derivative used alone or in combination with a bovinederived xenograft for the treatment of periodontal osseous defects in humans. J Periodontol 2002;73: 433-440.
40. Mariotti A. Efficacy of chemical root surface modifiers in the treatment of periodontal disease. Ann Periodontol 2003;8: 205-226.
41. Chambrone L, Chambrone D, Pustiglioni FE, Chambrone LA, Lima LA. The influence of tobacco smoking on the outcomes achieved by root coverage procedures. A systematic review. J Am Dent Assoc 2009;140: 294-306.
42. Chambrone LA, Chambrone L. Tooth loss in well maintained patients with chronic periodontitis during long-term supportive therapy in Brazil. J Clin Periodontol 2006;33: 759-764.
43. Tu Y-K, Tugnait A, Clerehugh V. Is there a temporal trend in the reported treatment efficacy of periodontal regeneration? A meta-analysis of randomized- controlled trials. J Clin Periodontol 2008;35: 139-146.
44. Lindhe J, Nyman S. Long-term maintenance of patients treated for advanced disease. J Clin Periodontol 1984;11: 504-514.
45. Nyman S, Rosling B, Lindhe J. Effect of professional tooth cleaning after periodontal surgery. J Clin Periodontol 1975;2: 80-86.
46. Rosling S, Nyman S, Lindhe J.The effect of systematic plaque control on bone regeneration in intrabony pockets. J Clin Periodontol 1976;3: 38-53.