PLP2 of mouse hepatitis Virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Wang, Gang ^a,c,d   Chen, Gang ^a,e   Zheng, Dahai ^a,f   Cheng, Genhong ^b   Tang, Hong ^a,c  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^e Insititute of Viral Disease   (China)

^f SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CELL PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; LYMPHOTOXIN; NONSTRUCTURAL PROTEIN 3; PAPAIN LIKE PROTEASE DOMAIN 2; PROTEIN KINASE; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; NSP3 PROTEIN, VIRUS; PAPAIN; PAPAIN LIKE PROTEINASE 2; PAPAIN-LIKE PROTEINASE 2; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; CYTOPLASM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HEPATITIS VIRUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; UBIQUITINATION; ANIMAL; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MURINE HEPATITIS CORONAVIRUS; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

MURINE HEPATITIS VIRUS; SARS CORONAVIRUS;

ANIMALS; CELLS, CULTURED; INTERFERON TYPE I; MICE; MURINE HEPATITIS VIRUS; PAPAIN; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSFECTION; UBIQUITINATION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 79951989445     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017192     Document Type: Article

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