메뉴 건너뛰기




Volumn 13, Issue 1, 2011, Pages 131-140

Biochemical modulation of aracytidine (Ara-C) effects by GTI-2040, a ribonucleotide reductase inhibitor, in K562 human leukemia cells

Author keywords

Ara CTP; GTI 2040; HPLC UV

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYTARABINE; CYTARABINE TRIPHOSPHATE; DEOXYRIBONUCLEOTIDE; GTI 2040; MESSENGER RNA; NUCLEOTIDE; RIBONUCLEOTIDE REDUCTASE;

EID: 79951974342     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-010-9246-5     Document Type: Review
Times cited : (4)

References (47)
  • 1
    • 0031849153 scopus 로고    scopus 로고
    • Ribonucleotide reductases and radical reactions
    • Fontecave M. Ribonucleotide reductases and radical reactions. Cell Mol Life Sci. 1998;54(7):684-95.
    • (1998) Cell Mol Life Sci , vol.54 , Issue.7 , pp. 684-695
    • Fontecave, M.1
  • 2
    • 0020541188 scopus 로고
    • Ribonucleotide reductase - A radical enzyme
    • New York, NY
    • Reichard P, Ehrenberg A. Ribonucleotide reductase - a radical enzyme. Science (New York, NY). 1983;221(4610):514-9.
    • (1983) Science , vol.221 , Issue.4610 , pp. 514-519
    • Reichard, P.1    Ehrenberg, A.2
  • 4
    • 2542504483 scopus 로고    scopus 로고
    • Structure, function, and mechanism of ribonucleotide reductases
    • Kolberg M, Strand KR, Graff P, Andersson KK. Structure, function, and mechanism of ribonucleotide reductases. Biochim Biophys Acta. 2004;1699(1-2):1-34.
    • (2004) Biochim Biophys Acta , vol.1699 , Issue.1-2 , pp. 1-34
    • Kolberg, M.1    Strand, K.R.2    Graff, P.3    Andersson, K.K.4
  • 5
    • 0029946035 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibitors: New strategies for cancer chemotherapy
    • Nocentini G. Ribonucleotide reductase inhibitors: new strategies for cancer chemotherapy. Crit Rev Oncol Hematol. 1996;22(2):89-126.
    • (1996) Crit Rev Oncol Hematol , vol.22 , Issue.2 , pp. 89-126
    • Nocentini, G.1
  • 6
    • 0024236511 scopus 로고
    • Ribonucleotide reductase as a chemotherapeutic target
    • Cory JG. Ribonucleotide reductase as a chemotherapeutic target. Adv Enzyme Regul. 1988;27:437-55.
    • (1988) Adv Enzyme Regul , vol.27 , pp. 437-455
    • Cory, J.G.1
  • 7
    • 0038615898 scopus 로고    scopus 로고
    • GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors
    • Lee Y, Vassilakos A, Feng N, Lam V, Xie H, Wang M, et al. GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors. Cancer Res. 2003;63(11):2802-11.
    • (2003) Cancer Res , vol.63 , Issue.11 , pp. 2802-2811
    • Lee, Y.1    Vassilakos, A.2    Feng, N.3    Lam, V.4    Xie, H.5    Wang, M.6
  • 8
    • 0042062334 scopus 로고    scopus 로고
    • Ribonucleotide reductase: An old target with new potential
    • Smith BD, Karp JE. Ribonucleotide reductase: an old target with new potential. Leuk Res. 2003;27(12):1075-6.
    • (2003) Leuk Res , vol.27 , Issue.12 , pp. 1075-1076
    • Smith, B.D.1    Karp, J.E.2
  • 9
    • 0028070503 scopus 로고
    • Inhibition of ribonucleotide reductase by 2′-substituted deoxycytidine analogs: Possible application in AIDS treatment
    • Bianchi V, Borella S, Calderazzo F, Ferraro P, Chieco Bianchi L, Reichard P. Inhibition of ribonucleotide reductase by 2′-substituted deoxycytidine analogs: possible application in AIDS treatment. Proc Natl Acad Sci USA. 1994;91(18):8403-7.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.18 , pp. 8403-8407
    • Bianchi, V.1    Borella, S.2    Calderazzo, F.3    Ferraro, P.4    Chieco Bianchi, L.5    Reichard, P.6
  • 10
    • 21344458583 scopus 로고    scopus 로고
    • A phase I study of antisense oligonucleotide GTI-2040 given by continuous intravenous infusion in patients with advanced solid tumors
    • Desai AA, Schilsky RL, Young A, Janisch L, Stadler WM, Vogelzang NJ, et al. A phase I study of antisense oligonucleotide GTI-2040 given by continuous intravenous infusion in patients with advanced solid tumors. Ann Oncol. 2005;16(6):958-65.
    • (2005) Ann Oncol , vol.16 , Issue.6 , pp. 958-965
    • Desai, A.A.1    Schilsky, R.L.2    Young, A.3    Janisch, L.4    Stadler, W.M.5    Vogelzang, N.J.6
  • 11
    • 0035446823 scopus 로고    scopus 로고
    • Therapeutic options for acute myelogenous leukemia
    • Estey EH. Therapeutic options for acute myelogenous leukemia. Cancer. 2001;92(5):1059-73.
    • (2001) Cancer , vol.92 , Issue.5 , pp. 1059-1073
    • Estey, E.H.1
  • 12
    • 0037246483 scopus 로고    scopus 로고
    • Recent advances in pediatric acute lymphoblastic and myeloid leukemia
    • Ravindranath Y. Recent advances in pediatric acute lymphoblastic and myeloid leukemia. Curr Opin Oncol. 2003;15(1):23-35.
    • (2003) Curr Opin Oncol , vol.15 , Issue.1 , pp. 23-35
    • Ravindranath, Y.1
  • 13
    • 0013955532 scopus 로고
    • Biochemical and pharmacological studies with 1-beta-D- arabinofuranosylcytosine in man
    • Creasey WA, Papac RJ, Markiw ME, Calabresi P, Welch AD. Biochemical and pharmacological studies with 1-beta-D-arabinofuranosylcytosine in man. Biochem Pharmacol. 1966;15(10):1417-28.
    • (1966) Biochem Pharmacol , vol.15 , Issue.10 , pp. 1417-1428
    • Creasey, W.A.1    Papac, R.J.2    Markiw, M.E.3    Calabresi, P.4    Welch, A.D.5
  • 14
    • 52449105507 scopus 로고    scopus 로고
    • Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia
    • Klisovic RB, Blum W, Wei X, Liu S, Liu Z, Xie Z, et al. Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia. Clin Cancer Res. 2008;14(12):3889-95.
    • (2008) Clin Cancer Res , vol.14 , Issue.12 , pp. 3889-3895
    • Klisovic, R.B.1    Blum, W.2    Wei, X.3    Liu, S.4    Liu, Z.5    Xie, Z.6
  • 16
    • 33745329502 scopus 로고    scopus 로고
    • A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices
    • Wei X, Dai G, Marcucci G, Liu Z, Hoyt D, Blum W, et al. A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices. Pharm Res. 2006;23(6):1251-64.
    • (2006) Pharm Res , vol.23 , Issue.6 , pp. 1251-1264
    • Wei, X.1    Dai, G.2    Marcucci, G.3    Liu, Z.4    Hoyt, D.5    Blum, W.6
  • 17
    • 67349234105 scopus 로고    scopus 로고
    • A LC-MS/MS method for the analysis of intracellular nucleoside triphosphate levels
    • Chen P, Liu Z, Liu S, Xie Z, Aimiuwu J, Pang J, et al. A LC-MS/MS method for the analysis of intracellular nucleoside triphosphate levels. Pharm Res. 2009;26(6):1504-15.
    • (2009) Pharm Res , vol.26 , Issue.6 , pp. 1504-1515
    • Chen, P.1    Liu, Z.2    Liu, S.3    Xie, Z.4    Aimiuwu, J.5    Pang, J.6
  • 18
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 1984;22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 19
    • 0023589415 scopus 로고
    • Biochemical pharmacology of high dose 1-beta-D-arabinofuranosylcytosine in childhood acute leukemia
    • Avramis VI, Biener R, Krailo M, Finklestein J, Ettinger L, Willoughby M, et al. Biochemical pharmacology of high dose 1-beta-D-arabinofuranosylcytosine in childhood acute leukemia. Cancer Res. 1987;47(24 Pt 1):6786-92.
    • (1987) Cancer Res , vol.47 , Issue.24 PART 1 , pp. 6786-6792
    • Avramis, V.I.1    Biener, R.2    Krailo, M.3    Finklestein, J.4    Ettinger, L.5    Willoughby, M.6
  • 20
    • 0034087978 scopus 로고    scopus 로고
    • Successful modulation of high-dose cytosine arabinoside metabolism in acute myeloid leukaemia by haematopoietic growth factors: No effect of ribonucleotide reductase inhibitors fludarabine and gemcitabine
    • Braess J, Wegendt C, Jahns-Streubel G, Kern W, Keye S, Unterhalt M, et al. Successful modulation of high-dose cytosine arabinoside metabolism in acute myeloid leukaemia by haematopoietic growth factors: no effect of ribonucleotide reductase inhibitors fludarabine and gemcitabine. Br J Haematol. 2000;109(2):388-95.
    • (2000) Br J Haematol , vol.109 , Issue.2 , pp. 388-395
    • Braess, J.1    Wegendt, C.2    Jahns-Streubel, G.3    Kern, W.4    Keye, S.5    Unterhalt, M.6
  • 21
    • 0022366259 scopus 로고
    • Relationship of 1-beta-D-arabinofuranosylcytosine in plasma to 1-beta-D-arabinofuranosylcytosine 5′-triphosphate levels in leukemic cells during treatment with high-dose 1-beta-D-arabinofuranosylcytosine
    • Liliemark JO, Plunkett W, Dixon DO. Relationship of 1-beta-D- arabinofuranosylcytosine in plasma to 1-beta-D-arabinofuranosylcytosine 5′-triphosphate levels in leukemic cells during treatment with high-dose 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1985;45(11 Pt 2):5952-7.
    • (1985) Cancer Res , vol.45 , Issue.11 PART 2 , pp. 5952-5957
    • Liliemark, J.O.1    Plunkett, W.2    Dixon, D.O.3
  • 22
    • 11144358126 scopus 로고    scopus 로고
    • The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients
    • Ossenkoppele GJ, Graveland WJ, Sonneveld P, Daenen SM, Biesma DH, Verdonck LF, et al. The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients. Blood. 2004;103(8):2908-13.
    • (2004) Blood , vol.103 , Issue.8 , pp. 2908-2913
    • Ossenkoppele, G.J.1    Graveland, W.J.2    Sonneveld, P.3    Daenen, S.M.4    Biesma, D.H.5    Verdonck, L.F.6
  • 23
    • 0031789029 scopus 로고    scopus 로고
    • Pharmacology of cytarabine given as a continuous infusion followed by mitoxantrone with and without amsacrine/etoposide as reinduction chemotherapy for relapsed or refractory pediatric acute myeloid leukemia
    • Ozkaynak MF, Avramis VI, Carcich S, Ortega JA. Pharmacology of cytarabine given as a continuous infusion followed by mitoxantrone with and without amsacrine/etoposide as reinduction chemotherapy for relapsed or refractory pediatric acute myeloid leukemia. Med Pediatr Oncol. 1998;31(6):475-82.
    • (1998) Med Pediatr Oncol , vol.31 , Issue.6 , pp. 475-482
    • Ozkaynak, M.F.1    Avramis, V.I.2    Carcich, S.3    Ortega, J.A.4
  • 24
    • 0019963710 scopus 로고
    • Clinical results and pharmacokinetics of high-dose cytosine arabinoside (HD ARA-C)
    • Breithaupt H, Pralle H, Eckhardt T, von Hattingberg M, Schick J, Loffler H. Clinical results and pharmacokinetics of high-dose cytosine arabinoside (HD ARA-C). Cancer. 1982;50(7):1248-57.
    • (1982) Cancer , vol.50 , Issue.7 , pp. 1248-1257
    • Breithaupt, H.1    Pralle, H.2    Eckhardt, T.3    Von Hattingberg, M.4    Schick, J.5    Loffler, H.6
  • 25
    • 0021341818 scopus 로고
    • Treatment of poor risk acute leukemia with sequential high-dose ARA-C and asparaginase
    • Capizzi RL, Poole M, Cooper MR, Richards 2nd F, Stuart JJ, Jackson Jr DV, et al. Treatment of poor risk acute leukemia with sequential high-dose ARA-C and asparaginase. Blood. 1984;63(3):694-700.
    • (1984) Blood , vol.63 , Issue.3 , pp. 694-700
    • Capizzi, R.L.1    Poole, M.2    Cooper, M.R.3    Richards II, F.4    Stuart, J.J.5    Jackson Jr., D.V.6
  • 26
    • 0025737279 scopus 로고
    • Effect of dose on the pharmacokinetic and pharmacodynamic effects of cytarabine
    • Capizzi RL, White JC, Powell BL, Perrino F. Effect of dose on the pharmacokinetic and pharmacodynamic effects of cytarabine. Semin Hematol. 1991;28(3 Suppl 4):54-69.
    • (1991) Semin Hematol , vol.28 , Issue.3 SUPPL. 4 , pp. 54-69
    • Capizzi, R.L.1    White, J.C.2    Powell, B.L.3    Perrino, F.4
  • 27
    • 0023470734 scopus 로고
    • Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia
    • Estey E, Plunkett W, Dixon D, Keating M, McCredie K, Freireich EJ. Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia. Leukemia. 1987;1(8):580-3.
    • (1987) Leukemia , vol.1 , Issue.8 , pp. 580-583
    • Estey, E.1    Plunkett, W.2    Dixon, D.3    Keating, M.4    McCredie, K.5    Freireich, E.J.6
  • 28
    • 34547702377 scopus 로고    scopus 로고
    • Effect of low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor priming (CAG regimen) on the outcome of elderly patients with acute myeloid leukemia
    • Qian SX, Li JY, Tian T, Shen YF, Jiang YQ, Lu H, et al. Effect of low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor priming (CAG regimen) on the outcome of elderly patients with acute myeloid leukemia. Leuk Res. 2007;31(10):1383-8.
    • (2007) Leuk Res , vol.31 , Issue.10 , pp. 1383-1388
    • Qian, S.X.1    Li, J.Y.2    Tian, T.3    Shen, Y.F.4    Jiang, Y.Q.5    Lu, H.6
  • 29
    • 0019948735 scopus 로고
    • High dose cytosine arabinoside in the management of refractory acute leukaemia
    • Willemze R, Zwaan FE, Colpin G, Keuning JJ. High dose cytosine arabinoside in the management of refractory acute leukaemia. Scand J Haematol. 1982;29(2):141-6.
    • (1982) Scand J Haematol , vol.29 , Issue.2 , pp. 141-146
    • Willemze, R.1    Zwaan, F.E.2    Colpin, G.3    Keuning, J.J.4
  • 30
    • 34547794827 scopus 로고    scopus 로고
    • Combined low-dose cytarabine, melphalan and mitoxantrone for older patients with acute myeloid leukemia or high-risk myelodysplastic syndrome
    • Yamauchi T, Negoro E, Arai H, Ikegaya S, Takagi K, Takemura H, et al. Combined low-dose cytarabine, melphalan and mitoxantrone for older patients with acute myeloid leukemia or high-risk myelodysplastic syndrome. Anticancer Res. 2007;27(4C):2635-9.
    • (2007) Anticancer Res , vol.27 , Issue.4 C , pp. 2635-2639
    • Yamauchi, T.1    Negoro, E.2    Arai, H.3    Ikegaya, S.4    Takagi, K.5    Takemura, H.6
  • 31
    • 39749118640 scopus 로고    scopus 로고
    • Combination chemotherapy with low-dose cytarabine, homoharringtonine, and granulocyte colony-stimulating factor priming in patients with relapsed or refractory acute myeloid leukemia
    • Zhang WG, Wang FX, Chen YX, Cao XM, He AL, Liu J, et al. Combination chemotherapy with low-dose cytarabine, homoharringtonine, and granulocyte colony-stimulating factor priming in patients with relapsed or refractory acute myeloid leukemia. Am J Hematol. 2008;83(3):185-8.
    • (2008) Am J Hematol , vol.83 , Issue.3 , pp. 185-188
    • Zhang, W.G.1    Wang, F.X.2    Chen, Y.X.3    Cao, X.M.4    He, A.L.5    Liu, J.6
  • 32
    • 10344238081 scopus 로고    scopus 로고
    • Amidox, an inhibitor of ribonucleotide reductase, potentiates the action of Ara-C in HL-60 human promyelocytic leukemia cells
    • Bauer W, Horvath Z, Hochtl T, Saiko P, Karl D, Fritzer-Szekeres M, et al. Amidox, an inhibitor of ribonucleotide reductase, potentiates the action of Ara-C in HL-60 human promyelocytic leukemia cells. Nucleosides Nucleotides Nucleic Acids. 2004;23(8-9):1541-4.
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , Issue.8-9 , pp. 1541-1544
    • Bauer, W.1    Horvath, Z.2    Hochtl, T.3    Saiko, P.4    Karl, D.5    Fritzer-Szekeres, M.6
  • 33
    • 0036683718 scopus 로고    scopus 로고
    • Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells
    • Fritzer-Szekeres M, Salamon A, Grusch M, Horvath Z, Hochtl T, Steinbrugger R, et al. Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells. Biochem Pharmacol. 2002;64(3):481-5.
    • (2002) Biochem Pharmacol , vol.64 , Issue.3 , pp. 481-485
    • Fritzer-Szekeres, M.1    Salamon, A.2    Grusch, M.3    Horvath, Z.4    Hochtl, T.5    Steinbrugger, R.6
  • 34
    • 0018104806 scopus 로고
    • Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin
    • Plagemann PG, Behrens M, Abraham D. Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin. Cancer Res. 1978;38(8):2458-66.
    • (1978) Cancer Res , vol.38 , Issue.8 , pp. 2458-2466
    • Plagemann, P.G.1    Behrens, M.2    Abraham, D.3
  • 35
    • 0030042611 scopus 로고    scopus 로고
    • Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: Pharmacokinetic, pharmacodynamic, and molecular interactions
    • Gandhi V, Estey E, Keating MJ, Chucrallah A, Plunkett W. Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions. Blood. 1996;87(1):256-64.
    • (1996) Blood , vol.87 , Issue.1 , pp. 256-264
    • Gandhi, V.1    Estey, E.2    Keating, M.J.3    Chucrallah, A.4    Plunkett, W.5
  • 36
    • 0029077399 scopus 로고
    • Modulation of arabinosylcytosine metabolism during leukemia therapy
    • Gandhi V, Estey E, Plunkett W. Modulation of arabinosylcytosine metabolism during leukemia therapy. Adv Exp Med Biol. 1994;370:119-24.
    • (1994) Adv Exp Med Biol , vol.370 , pp. 119-124
    • Gandhi, V.1    Estey, E.2    Plunkett, W.3
  • 37
    • 0024436221 scopus 로고
    • Modulation of arabinosylcytosine metabolism by arabinosyl-2-fluoroadenine in lymphocytes from patients with chronic lymphocytic leukemia: Implications for combination therapy
    • Gandhi V, Nowak B, Keating MJ, Plunkett W. Modulation of arabinosylcytosine metabolism by arabinosyl-2-fluoroadenine in lymphocytes from patients with chronic lymphocytic leukemia: implications for combination therapy. Blood. 1989;74(6):2070-5.
    • (1989) Blood , vol.74 , Issue.6 , pp. 2070-2075
    • Gandhi, V.1    Nowak, B.2    Keating, M.J.3    Plunkett, W.4
  • 38
    • 0025718578 scopus 로고
    • Effects of thymidine and hydroxyurea on the metabolism and cytotoxicity of 1-B-D arabinofuranosylcytosine in highly resistant human leukemia cells
    • Bhalla K, Swerdlow P, Grant S. Effects of thymidine and hydroxyurea on the metabolism and cytotoxicity of 1-B-D arabinofuranosylcytosine in highly resistant human leukemia cells. Blood. 1991;78(11):2937-44.
    • (1991) Blood , vol.78 , Issue.11 , pp. 2937-2944
    • Bhalla, K.1    Swerdlow, P.2    Grant, S.3
  • 39
    • 0026755674 scopus 로고
    • Increase in Ara-C sensitivity in Ara-C sensitive and -resistant leukemia by stimulation of the salvage and inhibition of the de novo pathway
    • Colly LP, Richel DJ, Arentsen-Honders MW, Kester MG, ter Riet PM, Willemze R. Increase in Ara-C sensitivity in Ara-C sensitive and -resistant leukemia by stimulation of the salvage and inhibition of the de novo pathway. Ann Hematol. 1992;65(1):26-32.
    • (1992) Ann Hematol , vol.65 , Issue.1 , pp. 26-32
    • Colly, L.P.1    Richel, D.J.2    Arentsen-Honders, M.W.3    Kester, M.G.4    Ter Riet, P.M.5    Willemze, R.6
  • 40
    • 27344445309 scopus 로고    scopus 로고
    • Electroporation by nucleofector is the best nonviral transfection technique in human endothelial and smooth muscle cells
    • Iversen N, Birkenes B, Torsdalen K, Djurovic S. Electroporation by nucleofector is the best nonviral transfection technique in human endothelial and smooth muscle cells. Genet Vaccines Therapy. 2005;3(1):2.
    • (2005) Genet Vaccines Therapy , vol.3 , Issue.1 , pp. 2
    • Iversen, N.1    Birkenes, B.2    Torsdalen, K.3    Djurovic, S.4
  • 41
    • 15044340106 scopus 로고    scopus 로고
    • Biochemical modulation of cytarabine triphosphate by clofarabine
    • Cooper T, Ayres M, Nowak B, Gandhi V. Biochemical modulation of cytarabine triphosphate by clofarabine. Cancer Chemother Pharmacol. 2005;55(4):361-8.
    • (2005) Cancer Chemother Pharmacol , vol.55 , Issue.4 , pp. 361-368
    • Cooper, T.1    Ayres, M.2    Nowak, B.3    Gandhi, V.4
  • 42
    • 0025020135 scopus 로고
    • The effect of Ara-C-induced inhibition of DNA synthesis on its cellular pharmacology
    • Wang LM, White JC, Capizzi RL. The effect of Ara-C-induced inhibition of DNA synthesis on its cellular pharmacology. Cancer Chemother Pharmacol. 1990;25(6):418-24.
    • (1990) Cancer Chemother Pharmacol , vol.25 , Issue.6 , pp. 418-424
    • Wang, L.M.1    White, J.C.2    Capizzi, R.L.3
  • 43
    • 0036533498 scopus 로고    scopus 로고
    • Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line
    • Verschuur AC, Van Gennip AH, Leen R, Voute PA, Brinkman J, Van Kuilenburg AB. Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line. Int J Cancer. 2002;98(4):616-23.
    • (2002) Int J Cancer , vol.98 , Issue.4 , pp. 616-623
    • Verschuur, A.C.1    Van Gennip, A.H.2    Leen, R.3    Voute, P.A.4    Brinkman, J.5    Van Kuilenburg, A.B.6
  • 44
    • 0017926507 scopus 로고
    • Increased CTP synthetase activity in cancer cells
    • Williams JC, Kizaki H, Weber G, Morris HP. Increased CTP synthetase activity in cancer cells. Nature. 1978;271(5640):71-3.
    • (1978) Nature , vol.271 , Issue.5640 , pp. 71-73
    • Williams, J.C.1    Kizaki, H.2    Weber, G.3    Morris, H.P.4
  • 45
    • 2342467325 scopus 로고    scopus 로고
    • Problems related to resistance to cytarabine in acute myeloid leukemia
    • Cros E, Jordheim L, Dumontet C, Galmarini CM. Problems related to resistance to cytarabine in acute myeloid leukemia. Leuk Lymphoma. 2004;45(6):1123-32.
    • (2004) Leuk Lymphoma , vol.45 , Issue.6 , pp. 1123-1132
    • Cros, E.1    Jordheim, L.2    Dumontet, C.3    Galmarini, C.M.4
  • 46
    • 0021966123 scopus 로고
    • Simultaneous determination of cytosine arabinoside, its nucleotides and metabolites by ion-pair high-performance liquid chromatography
    • Schilsky RL, Ordway FS. Simultaneous determination of cytosine arabinoside, its nucleotides and metabolites by ion-pair high-performance liquid chromatography. J Chromatogr. 1985;337(1):63-71.
    • (1985) J Chromatogr , vol.337 , Issue.1 , pp. 63-71
    • Schilsky, R.L.1    Ordway, F.S.2
  • 47
    • 0018906892 scopus 로고
    • Quantitation of 1-beta-D-arabinofuranosylcytosine 5′-triphosphate in the leukemic cells from bone marrow and peripheral blood of patients receiving 1-beta-D-arabinofuranosylcytosine therapy
    • Plunkett W, Hug V, Keating MJ, Chubb S. Quantitation of 1-beta-D-arabinofuranosylcytosine 5′-triphosphate in the leukemic cells from bone marrow and peripheral blood of patients receiving 1-beta-D- arabinofuranosylcytosine therapy. Cancer Res. 1980;40(3):588-91.
    • (1980) Cancer Res , vol.40 , Issue.3 , pp. 588-591
    • Plunkett, W.1    Hug, V.2    Keating, M.J.3    Chubb, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.