Stenotrophomonas maltophilia resistance to trimethoprim/sulfamethoxazole mediated by acquisition of sul and dfrA genes in a plasmid-mediated class 1 integron

International Journal of Antimicrobial Agents

Volumn 37, Issue 3, 2011, Pages 230-234

  Hu, Li Fen ^a   Chang, Xiao ^a   Ye, Ying ^a   Wang, Zhong Xin ^a   Shao, Yi Bo ^a   Shi, Wei ^a   Li, Xu ^a   Li, Jia Bin ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Antibiotic resistance; Class 1 integron; Gene cassette; Stenotrophomonas maltophilia; Trimethoprim sulfamethoxazole

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CEFTAZIDIME; CHLORAMPHENICOL; COTRIMOXAZOLE; LEVOFLOXACIN; MINOCYCLINE; RIFAMPICIN; TIMENTIN;

AAC GENE; AACA4 GENE; AADA1 GENE; AADA5 GENE; AADB GENE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARR 3 GENE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CATB8 GENE; CHINA; CONTROLLED STUDY; DFRA GENE; DFRA12 GENE; DFRA17 GENE; GENE CASSETTE; GENE LOCATION; GENE SEQUENCE; GRAM NEGATIVE INFECTION; HUMAN; INTEGRON; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; STENOTROPHOMONAS MALTOPHILIA; SUL GENE; SUL1 GENE; SUL2 GENE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; CARRIER PROTEINS; CHINA; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; INTEGRONS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; STENOTROPHOMONAS MALTOPHILIA; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

EID: 79951957427     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.10.025     Document Type: Article

References (15)

1. M. Denton, N.J. Todd, K.G. Kerr, P.M. Hawkey, and J.M. Littlewood Molecular epidemiology of Stenotrophomonas maltophilia isolated from clinical specimens from patients with cystic fibrosis and associated environmental samples J Clin Microbiol 36 1998 1953 1958 (Pubitemid 28277783)
2. R. Hugh, and E. Ryschenkow Pseudomonas maltophilia, an Alcaligenes-like species J Gen Microbiol 26 1961 123 132
3. C.H. Lai, C.Y. Chi, H.P. Chen, T.L. Chen, C.J. Lai, and C.P. Fung Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia bacteremia J Microbiol Immunol Infect 37 2004 350 358
4. R. Barbolla, M. Catalano, B.E. Orman, A. Famiglietti, C. Vay, and J. Smayevsky Class 1 integrons increase trimethoprim/sulfamethoxazole MICs against epidemiologically unrelated Stenotrophomonas maltophilia isolates Antimicrob Agents Chemother 48 2004 666 669 (Pubitemid 38141741)
5. M.A. Toleman, P.M. Bennett, D.M. Bennett, R.N. Jones, and T.R. Walsh Global emergence of trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia mediated by acquisition of sul genes Emerg Infect Dis 13 2007 559 565 (Pubitemid 46525100)
6. S.J. Liaw, Y.L. Lee, and P.R. Hsueh Multidrug resistance in clinical isolates of Stenotrophomonas maltophilia: roles of integrons, efflux pumps, phosphoglucomutase (SpgM), and melanin and biofilm formation Int J Antimicrobial Agents 35 2010 126 130
7. C. Lin-Li, L. Hui-Hui, C. Chung-Yu, and L. Po-Liang Increased incidence of class 1 integrons in trimethoprim/sulfamethoxazole-resistant clinical isolates of Stenotrophomonas maltophilia J Antimicrob Chemother 59 2007 1038 1039
8. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; eighteenth informational supplement. Document M100-S18. Wayne, PA: CLSI; 2008.
9. C. Levesque, L. Pyche, C. Larose, and P.H. Roy PCR mapping of integrons reveals several novel combinations of resistance genes Antimicrob Agents Chemother 39 1995 185 191
10. P.A. White, C.J. McIver, and W.D. Rawlinson Integrons and gene cassettes in the Enterobacteriaceae Antimicrob Agents Chemother 45 2001 2658 2661 (Pubitemid 32801929)
11. C. Goldstein, M.D. Lee, S. Sanchez, C. Hudson, B. Phillips, and B. Register Incidence of class 1 and 2 integrases in clinical and commensal bacteria from livestock, companion animals, and exotics Antimicrob Agents Chemother 45 2001 723 726 (Pubitemid 32182015)
12. Z. Yueqing, and L. Kailai Genes resistant to disinfectant-sulfanilamide, class 1 integrase and aminoglycoside-modifying enzyme in Acinetobacter baumannii Chin J Nosocomiol 15 2005 728 731 [in Chinese]
13. S. Haiping, and L. Ning Study on the genes of SMZco resistance in multi-drug-resistant strains of Escherichia coli J Mod Lab Med 23 2008 42 43 [in Chinese]
14. S. Dutta, Y. Kawamura, T. Ezaki, G.B. Nair, K. Iida, and S.-I. Yoshida Alteration in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant Shigella dysenteriae serotype 1 clinical isolates from Kolkata, India Antimicrob Agents Chemother 49 2005 1660 1661 (Pubitemid 40463416)
15. C.I. Kado, and S.T. Liu Rapid procedure for detection and isolation of large and small plasmids J Bacteriol 145 1981 1365 1373 (Pubitemid 11097357)