Inappropriate calibration and optimisation of pan-keratin (pan-CK) and low molecular weight keratin (LMWCK) immunohistochemistry tests: Canadian Immunohistochemistry Quality Control (CIQC) experience

Journal of Clinical Pathology

Volumn 64, Issue 3, 2011, Pages 220-225

  Copete, Maria ^a   Garratt, John ^b   Gilks, Blake ^c   Pilavdzic, Dragana ^d   Berendt, Richard ^e,f   Bigras, Gilbert ^e,f   Mitchell, Sarah ^e,f   Lining, Leslie Ann ^a   Cheung, Carol ^g   Torlakovic, Emina E ^a,g  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b LIONS GATE HOSPITAL   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF ALBERTA   (Canada)

^f CROSS CANCER INSTITUTE   (Canada)

^g UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

KERATIN; LOW MOLECULAR WEIGHT KERATIN; PANCYTOKERATIN; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOMETRIOID CARCINOMA; EPITHELIUM CELL; EPITHELIUM DIFFERENTIATION; FALSE NEGATIVE RESULT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; LIVER CELL; MESOTHELIOMA; PRIORITY JOURNAL; QUALITY CONTROL; SMALL CELL CARCINOMA; TISSUE MICROARRAY;

CANADA; FALSE NEGATIVE REACTIONS; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; KERATINS; LABORATORIES; MALE; MOLECULAR WEIGHT; NEOPLASM PROTEINS; NEOPLASMS; QUALITY CONTROL; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 79951956835     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2010.085258     Document Type: Article

References (14)

1. Taylor CR, Shi S-R, Barr NJ, et al. Techniques in immunohistochemistry: principles, pitfalls, and standardization. In: Dabbs D, ed. Diagnostic Immunohistochemistry. 2nd edn. New York. NY: Churchill Livingstone Elsevier, 2006:1-42.
2. Torlakovic EE, Riddell R, Banerjee D, et al. Canadian Association of Pathologists- Association canadienne des pathologistes National Standards Committee/ Immunohistochemistry: best practice recommendations for standardization of immunohistochemistry tests. Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee. Am J Clin Pathol 2010;133:354-65.
3. Vyberg M, Torlakovic E, Seidal T, et al. Nordic immunohistochemical quality control. Croat Med J 2005;46:368-71. (Pubitemid 40686478)
4. Rüdiger T, Höfler H, Kreipe HH, et al. Quality assurance in immunohistochemistry: results of an interlaboratory trial involving 172 pathologists. Am J Surg Pathol 2002;26:873-82. (Pubitemid 34747639)
5. Taylor CR, Levenson RM. Quantification of immunohistochemistry-issues concerning methods, utility and semiquantitative assessment II. Histopathology 2006;49:411-24. (Pubitemid 44401549)
6. Moll R, Divo M, Langbein L. The human keratins: biology and pathology. Histochem Cell Biol 2008;129:705-33.
7. Schweizer J, Bowden PE, Coulombe PA, et al. New consensus nomenclature for mammalian keratins. J Cell Biol 2006;174:169-74. (Pubitemid 44079852)
8. Carbone A, Gloghini A, Rinaldo A, et al. True identity by immunohistochemistry and molecular morphology of undifferentiated malignancies of the head and neck. Head Neck 2009;31:949-61.
9. Bahrami A, Truong LD, Ro JY. Undifferentiated tumor: true identity by immunohistochemistry. Arch Pathol Lab Med 2008;132:326-48. (Pubitemid 351328809)
10. Williams J. The general pathology module: Melanoma markers (S100/HMB45) & cytokeratins. Immunocytochemistry 2006;4:99-105.
11. Nielsen S, Vyberg M, Steensgaard A. Assessment Run 25 2009. http://www. nordiqc.org/Run-25/Assessment/assessment-CK-LMW.htm (accessed 22 Jun 2010).
12. Nielsen S, Vyberg M, Steensgaard A. Assessment Run 245 2008. http://www. nordiqc.org/Run-24-B6/Assessment/assessment-CK-Pan.htm (accessed 22 Jun 2010).
13. Goldstein NS, Hewitt SM, Taylor CR, et al. Members of Ad-Hoc Committee On Immunohistochemistry Standardization. Recommendations for improved standardization of immunohistochemistry. Appl Immunohistochem Mol Morphol 2007;15:124-33. (Pubitemid 46828218)
14. Packeisen J, Buerger H, Krech R, et al. Tissue microarrays: a new approach for quality control in immunohistochemistry. J Clin Pathol 2002;55:613-15.