The potential danger of a solely interferon-γ release assay-based approach to testing for latent Mycobacterium tuberculosis infection in children

Thorax

Volumn 66, Issue 3, 2011, Pages 263-264

  Connell, T G ^a   Tebruegge, M ^a   Ritz, N ^a   Bryant, P ^a   Curtis, Nigel ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ASSAY; CHILD; HIGH RISK PATIENT; HUMAN; INFECTION; LETTER; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULIN TEST;

EID: 79951955737     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2010.143396     Document Type: Letter

References (12)

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3. Connell TG, Ritz N, Paxton GA, et al. A three-way comparison of tuberculin skin testing, QuantiFERON-TB gold and T-SPOT.TB in children. PLoS One 2008;3: e2624.
4. Chun JK, Kim CK, Kim HS, et al. The role of a whole blood interferon-gamma assay for the detection of latent tuberculosis infection in Bacille Calmette-Guerin vaccinated children. Diagn Microbiol Infect Dis 2008;62:389-94.
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9. Tsiouris SJ, Austin J, Toro P, et al. Results of a tuberculosis-specific IFN-gamma assay in children at high risk for tuberculosis infection. Int J Tuberc Lung Dis 2006;10:939-41. (Pubitemid 44197857)
10. Connell TG, Tebruegge M, Ritz N, et al. Indeterminate interferon-gamma release assay results in children. Pediatr Infect Dis J 2010;29:285-6.
11. Haustein T, Ridout DA, Hartley JC, et al. The likelihood of an indeterminate test result from a whole-blood interferon-gamma release assay for the diagnosis of Mycobacterium tuberculosis infection in children correlates with age and immune status. Pediatr Infect Dis J 2009;28:669-73.
12. Powell DA. Interferon gamma release assays in the evaluation of children with possible Mycobacterium tuberculosis infection: a view to caution. Pediatr Infect Dis J 2009;28:676-7.