Successful use of recombinant FVIIa in combined factor V and FVIII deficiency with surgical bleeding resistant to substitutive treatment. A case report

Haemophilia

Volumn 17, Issue 1, 2011, Pages 160-161

  Di Marzio, I ^a   Iuliani, O ^a   Malizia, R ^a   Rolandi, G ^a   Sanna, S ^b   Castaman, G ^b   Dragani, A ^a  

^a SPIRITO SANTO HOSPITAL   (Italy)

^b SAN BORTOLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ADULT; ARTICLE; BLEEDING; BLOOD CLOTTING FACTOR 5 DEFICIENCY; BLOOD CLOTTING FACTOR DEFICIENCY; CASE REPORT; CLINICAL FEATURE; EXON; FAMILY HISTORY; FEMALE; GENE MUTATION; HETEROZYGOSITY; HUMAN; LABORATORY TEST; PRIORITY JOURNAL;

ADULT; FACTOR V DEFICIENCY; FACTOR VIIA; FEMALE; HEMATOMA; HEMOPHILIA A; HUMANS; MANNOSE-BINDING LECTINS; MEMBRANE PROTEINS; POSTOPERATIVE HEMORRHAGE; RECOMBINANT PROTEINS; TREATMENT OUTCOME; VESICULAR TRANSPORT PROTEINS;

EID: 79951935713     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2010.02368.x     Document Type: Article

References (5)

1. Spreafico M, Peyvandi F. Combined FV and FVIII deficiency. Haemophilia 2008; 14: 1201-8.
2. Zhang B, Spreafico M, Zheng C et al. Genotype-phenotype correlation in combined deficiency of factor V and factor VIII. Blood 2008; 111: 5592-600.
3. Zhang B. Recent development in the understanding of the combined deficiency of FV and FVIII. Br J Haematol 2009; 145: 15-23.
4. Bolton Maggs PHB, Perry DJ, Chalmers A et al. The rare coagulation disorders-review with guidelines for the management from the United Kingdom Haemophilia Centre Doctor's Organization. Haemophilia 2004; 10: 593-628.
5. Rosovsky RP, Crowther Mark A. what is the evidence for the off-label use of recombinant factor VIIa (rFVIIa) in the acute reversal of warfarin. ASH Evidence-based Review 2008.